Review of the State of Brachytherapy at the Present Stage for Pediatric Oncology Development
https://doi.org/10.37174/2587-7593-2019-2-4-5-12
Abstract
This article, based on an analysis of the results of the work of leading cancer centers in the world, provides an overview of the possibilities of brachytherapy in the treatment of malignant tumors in children, presents indications for brachytherapy at the present stage of development of pediatric oncology. Malignant neoplasms in children are relatively rare, with an annual frequency of 13–14 cases per 100,000 children under the age of 15 years and make up less than 1 % of all cancer cases in developed countries.
In the treatment of tumors in children, as a rule, a multimodal (integrated) approach is used. A treatment program usually includes surgery, chemotherapy, and external radiation therapy. Treatment strategies aimed at reducing late side effects have significantly increased interest in brachytherapy, in particular in the treatment of soft tissue sarcoma and clear cell adenocarcinoma, since in these malignant neoplasms only a limited target volume should receive a significant radiation dose, often exceeding the tolerant doses of the surrounding swelling of normal tissues and structures.
The article contains the following sections:
• Introduction
• Methodological aspects of brachytherapy in children
• Clinical indications for the use of brachytherapy in children, depending on tumor localization
› Brachytherapy of clear cell adenocarcinoma in children
› Technique for brachytherapy in children
› Total focal dose, dose rate and fractionation of brachytherapy in children
• Conclusions
About the Author
E. L. Slobina
Russian Scientific Center of Roentgenoradiology
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Slobina E.L. Review of the State of Brachytherapy at the Present Stage for Pediatric Oncology Development. Journal of oncology: diagnostic radiology and radiotherapy. 2019;2(4):5-12. (In Russ.) https://doi.org/10.37174/2587-7593-2019-2-4-5-12
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