Control of Chemotherapeutic Perfusion of Isolated Limb in Patients with Melanoma or Sarcom Soft Tissues
https://doi.org/10.37174/2587-7593-2019-2-2-28-35
Abstract
A technology has been developed for radiometric monitoring of regional perfusion in order to ensure continuous monitoring of the possible leakage of a chemotherapy drug from a surgically isolated limb during high-dose chemotherapy in patients with melanoma or sarcoma of soft tissues. The technology is based on in vivo labeling of erythrocytes with 99mTc eluate followed by continuous monitoring of changes in the activity of labeled erythrocytes as a chemotherapy simulator in a well vascularized body region. Its distinctive features are intravenous injection of a pyrfotech slice after giving inhalation anesthesia to ensure a sufficient level of red blood cell chelation, as well as using 99mTc activity less than its minimum significant level, which allows working with an open source of ionizing radiation without violating the requirements of radiation safety regulations. At 106 regional perfusion procedures, the clinical efficacy of the proposed radiometric monitoring technology is shown.
About the Authors
B. Ya. Narkevich
N.N. Blokhin National Medical Research Center of Oncology; Association of Medical Physicists of Russia
Russian Federation
Moscow.
Russian Federation
Moscow.
S. V. Shiryaev
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow.
Russian Federation
Moscow.
I. V. Lagutina
N.N. Blokhin National Medical Research Center of Oncology; Association of Medical Physicists of Russia
Russian Federation
Moscow.
Russian Federation
Moscow.
Yu. V. Buydenok
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow.
Russian Federation
Moscow.
T. K. Kharatishvili
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow.
Russian Federation
Moscow.
N. S. Petrochenko
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow.
Russian Federation
Moscow.
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Review
For citations:
Narkevich B.Ya., Shiryaev S.V., Lagutina I.V., Buydenok Yu.V., Kharatishvili T.K., Petrochenko N.S. Control of Chemotherapeutic Perfusion of Isolated Limb in Patients with Melanoma or Sarcom Soft Tissues. Journal of oncology: diagnostic radiology and radiotherapy. 2019;2(2):28-35. (In Russ.) https://doi.org/10.37174/2587-7593-2019-2-2-28-35
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