Pseudoprogression of Low Grade Glioma (Pilocytic Astrocytoma) of Midbrain. Case report
https://doi.org/10.37174/2587-7593-2018-1-1-94-97
Abstract
Pilocytic astrocytomas (PA) are the most common gliomas (WHO 1) in children. According to many authors stereotactic irradiation (radiotherapy and radiosurgery) (SI) is an effective method which provides a long time progression‑free survival in patients after incomplete tumor resection or with recurrence.
We present a case of midbrain PA, which has demonstrated a prominent tumor enlargement during the first 7 months after the irradiation with subsequent complete response in 12 months without any antitumor treatment. The follow up clinical and radiologic investigations in the case, similar cases observed and published data allow to assume that the enlargement in early period after irradiation usually represents pseudoprogression.
Understanding of this phenomenon provides the proper assessment of treatment results and allows to avoid unnecessary antitumor treatment.
About the Authors
Y. Y. Trunin
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Golanov
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
V. V. Kostjuchenko
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
M. V. Galkin
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
E. A. Khukhlaeva
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
A. N. Konovalov
N.N. Burdenko National Medical Research Center of Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Douw L., Klein M., Fagel S. et al. Cognitive and radiological effects of radiotherapy in patients with low grade glioma. Longterm follow up // Lancet Neurology. 2009. Vol. 8. № 9. P. 810– 818. Doi: 10.1016/S1474-4422(09)70204-2.
2. Fernandez C., Figarella Branger D., Girard N. et al. Pilocytic astrocytomas in children: prognostic factors – a retrospective study of 80 cases // Neurosurgery. 2003. Vol. 53. № 3. P. 544–553; discussion 554–555.
3. Simonova G., Novotny J. Jr, Liscak R. Low grade gliomas treated by fractionated Gamma knife surgery // J. Neurosurgery. 2005. Vol. 202. Suppl. P. 19–24.
4. Trunin Y., Golanov A., Konovalov A. et al. Stereotactic radiation therapy and radiosurgery for brain pilocytic astrocytomas // J. Radiosurg. & SBRT. 2013. Suppl. 2.1. Vol. 2. P. 34.
5. Naftel R.P., Pollack I.F., Zuccoli G. et al. Pseudoprogression of low grade gliomas after radiotherapy // Pediatric Blood & Cancer. 2015. Vol. 62. № 1. P. 35–39. Doi: 10.1002/pbc.25179.
Review
For citations:
Trunin Y.Y., Golanov A.V., Kostjuchenko V.V., Galkin M.V., Khukhlaeva E.A., Konovalov A.N. Pseudoprogression of Low Grade Glioma (Pilocytic Astrocytoma) of Midbrain. Case report. Journal of oncology: diagnostic radiology and radiotherapy. 2018;1(1):94-97. (In Russ.) https://doi.org/10.37174/2587-7593-2018-1-1-94-97
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