SPECT/CT for Treatment Monitoring of Osteosarcoma Bone Metastases
https://doi.org/10.37174/2587-7593-2018-1-1-86-93
Abstract
Purpose: To demonstrate the diagnostic capabilities to control effects of radiotherapy and HIFU treatment in patient with osteosarcoma bone metastases by SPECT/CT method.
Material and methods. It was conducted SPECT/CT treatment monitoring of the patient with bone metastases of osteosarcoma after external radiotherapy, ultrasound ablation and cyber knife.
Results. It were detected changes in the SPECT/CT-images of treated bones osteosarcoma metastases in short time. The treatment effect induced by ultrasound ablation was manifested after 1 month observation. The SPECT/CT has proven as a reliable method of dynamic control at radiotherapy. The treatment effect all of these methods is to reduce or absence of accumulation bone-tropic radiopharmaceutical labeled with 99mTc.
Conclusion. SPECT/CT study is demonstrative method for early determination of pathological metabolism degree at bone metastases of osteosarcoma after radiotherapy and HIFU. SPECT/CT is an effective method of treatment monitoring of bone metastases after radiotherapy and HIFU therapies.
About the Authors
A. D. Ryzhkov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
S. M. Ivanov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
A. S. Krylov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
S. V. Shiryaev
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
G. N. Machak
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
N. V. Kochergina
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
A. B. Bludov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Nazarenko
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
M. E. Bilik
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Назаренко A.И., Хитрова А.Н., Краснова Т.В., Богданов Е.Г. Инновационный метод ультразвуковой аблации опухолей человека (обзор литературы и собственные наблюдения) // Ультразвуковая и функциональная диагностика. 2008. Вып. 70. С. 4–26.
2. Chen W., Zhu H., Zhang L. et al. Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation // Radiology. 2010. Vol. 255. № 3. P. 967–978. doi: 10.1148/radiol.10090374.
3. Li C., Wu P., Zhang L. et al. Osteosarcoma: limb salvaging treatment by ultrasonographically guided high-intensity focused ultrasound // Cancer Biol. Ther. 2009. Vol. 8. № 12. P. 1102–1108. Epub 2009 Jun 27.
4. Li C., Zhang W., Fan W. et al. Noninvasive treatment of malignant bone tumors using high-intensity focused ultrasound // Cancer. 2010. Vol. 116. № 16. P. 3934–3942. doi: 10.1002/cncr.25192.
5. Orgera G., Monfardini L., Della Vigna P. et al. High-intensity focused ultrasound (HIFU) in patients with solid malignancies: evaluation of feasibility, local tumour response and clinical results // Radiol. Med. 2011. Vol. 116. № 5. P. 734–748. doi: 10.1007/s11547-011-0634-4. Epub 2011 Feb 1.
6. Wu F., Chen W.Z., Bai J. et al. Pathologic changes in human malignant carcinoma treated with high-intensity focused ultrasound // Ultrasound Med. Biol. 2001. Vol. 27. P. 1099–1106.
7. Lynn J.G., Zwemer R.L., Chick A.J. et al. A new method for the generation and use of focused ultrasound in experimental biology // J. Gen. Physiol. 1942. Vol. 26. P. 179–193.
8. Clement G.T. Perspectives in clinical uses of high-intensity focused ultrasound // Ultrasonics. 2004. Vol. 42. P. 1087–1093.
9. Mason T.J. A sound investment // Chem. Ind. 1998. P. 878–882
10. Wu F., Chen W.Z., Bai J. et al. Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies // Ultrasound Med. Biol. 2002. Vol. 28. P. 535–542.
11. Yu W., Tang L., Lin F. et al. High-intensity focused ultrasound: Noninvasive treatment for local unresectable recurrence of osteosarcoma // Surg. Oncol. 2014. pii: S0960-7404(14)00075-9. doi: 10.1016/j.suronc.2014.10.001.
12. Caglar M., Tuncel M., Velipasaoglu Z., Karakaya J. Incremental diagnostic value of SPECT/CT in patients with suspected bone metastases // J. Nucl. Med. 2013. Vol. 54. P. 418–424.
13. Keidar Z., Israel O., Krausz Y. SPECT/CT in tumor imaging: technical aspects and clinical applications // Semin. Nucl. Med. 2003. Vol. 33. P. 205–218.
14. Krzhivitskiĭ P.I., Kanaev S.V., Novikov S.N. et al. SPECT-CT in the diagnosis of metastatic skeletal lesion // Vopr. Onkol. 2014. Vol. 60. № 1. P. 56–63.
15. Utsunomiya D., Shiraishi S., Imuta M. et al. Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT // Radiology. 2006. Vol. 238. P. 264–271.
16. Buck K., Nekolla S., Ziegler S. et al. SPECT/CT // J. Nucl. Med. 2008. Vol. 49. P. 1305–1319. Doi: 10.2967/jnumed.107.050195.
17. Romer W., Nomayr A., Uder M. et al. SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients // J. Nucl. Med. 2006. Vol. 47. P. 1102–1106.
18. Рыжков А.Д., Иванов С.М., Ширяев С.В. и соавт. ОФЭКТ/ КТ в контроле лучевого лечения костных метастазов остеосаркомы // Вопр. онкол. 2016. Т. 62. № 5. С. 654–659.
19. Рыжков А.Д., Ширяев С.В., Мачак Г.Н. и соавт. ОФЭКТ/КТ в контроле лечения костных метастазов остеосаркомы методом ультразвуковой термоаблации // Мед. радиол. и радиац. безопасность. 2016. Т. 61. № 5. С. 54–58.
Review
For citations:
Ryzhkov A.D., Ivanov S.M., Krylov A.S., Shiryaev S.V., Machak G.N., Kochergina N.V., Bludov A.B., Nazarenko A.V., Bilik M.E. SPECT/CT for Treatment Monitoring of Osteosarcoma Bone Metastases. Journal of oncology: diagnostic radiology and radiotherapy. 2018;1(1):86-93. (In Russ.) https://doi.org/10.37174/2587-7593-2018-1-1-86-93
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