Possibilities of Using Transarterial Chemoembolization in Patients with Metastases of Choroidal Melanoma in Liver

Purpose: To evaluate the safety and efficacy of transarterial chemoembolization method (TACE) in the treatment of inoperable patients with uveal melanoma with isolated liver metastases with cured the primary focus.

Material and methods: In N.N. Blokhin NMRCO since 2000, 31 patients received treatment with metastatic uveal melanoma in the liver. Among them: men 13 (42 %), women 18 (58 %). The average age of 45.1 ± 13.2 years, range 23–71 years. Liver lesion volume was 25 % in patients 11 to 50 % in 13 to 75 % in 7 patients. Total 62 TACE intervention was performed. As used embolizing materials: 31 patients lipiodol 10 ml in 53 cases, microspheres – in 17 cases (particle sizes ranged from 100 to 500 microns), combinations presented embolizing materials have been used in 6 patients. As the chemotherapy Doxorubicin performed at a dosage of 100 mg, or Gemzar 1–2 g, or Carboplatin 450 mg.

Results: 100 % of the TACE was technically successful. Complications related to the technical implementation not observed. Local response was observed in 21/31 (67.7 %) patients with metastatic uveal melanoma. Duration of monitoring of patients after TACE was held from 2 to 60 months. Overall 1-year survival in this group of patients was 51.0 ± 9.5 %. 2-year 34.0 ± 15.2 %. The median survival – 12.9 month. 20 patients were alive at the time of the study, 11 died from progression.

Conclusions: In our study transarterial chemoembolization in patients with metastatic uveal melanoma in the liver has established itself as an effective and well-tolerated treatment. Objective response or stabilization process in the liver was observed in 68 % of patients. A median overall survival was comparable to that provided in the literature.

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