History of Development and Achievements of the Institute of Experimental and Clinical Oncology in Proton Radiotherapy
https://doi.org/10.37174/2587-7593-2025-8-1-19-28
Abstract
Purpose: The article is devoted to the history of the development of proton radiotherapy and the achievements of the Institute of Experimental and Clinical Oncology (now the Federal State Budgetary Institution ͞N.N. Blokhin National Medical Research Center of Oncology͟ of the Ministry of Health of the Russian Federation) in proton radiation therapy.
Matreial and Methods: Proton radiotherapy has been used in the treatment of patients since 1967 with tumors of the breast, prostate, thyroid gland, tongue, esophagus, larynx, cervix, vulva, malignant melanoma, osteogenic sarcoma, metastases to the liver, lungs, bones, soft tissues, skin, etc. Treatment was carried out at the Centes for Proton Beam Therapy of Dubna and Moscow.
Results: N.N. Blokhin National Medical Research Center of Oncology belongs to 2/3 of the total clinical experience proton radiоtherapy in Russia. This is 2351 patients. The greatest experience is useful in treating patients with breast cancer. This is 1243 patients.
About the Authors
I. A. GladilinaRussian Federation
Irina A. Gladilina
24 Kashirskoye Shosse, Moscow, 115478
1 Ostrovityanov Str., Moscow, 117997
Competing Interests:
Not declared
I. M. Lebedenko
Russian Federation
Irina M. Lebedenko
24 Kashirskoye Shosse, Moscow, 115478
31 Kashirskoye Shosse, Moscow, 115409
Competing Interests:
Not declared
M. V. Chernykh
Russian Federation
Marina V. Chernykh
24 Kashirskoye Shosse, Moscow, 115478
Competing Interests:
Not declared
E. A. Sukhova
Russian Federation
Ekaterina A. Sukhova
1 Ostrovityanov Str., Moscow, 117997
Competing Interests:
Not declared
References
1. Blokhin NN, Weinberg MS, Ruderman AI. Use of charged particle accelerators in radiation therapy of cancer patients. Bulletin of the Academy of Medical Sciences of the USSR.͟1974;4:3-10 (In Russ.)
2. Goldin LL, Vorontsov IA, Khoroshkov VS et al. Proton therapy in the USSR. M. TsNII atominform. 1988. (In Russ.)
3. Goldin LL, Dzhelepov VP. Advances in physical sciences. 1973; 110:2:77 (In Russ.)
4. Dzhelepov VP, Savchenko OV, Komarov VI et al. The use of proton beams in the USSR for medical and biological purposes. In the book: Peaceful uses of Atomic Energy. Vienna. 1972;13:752 (In Russ.)
5. Dmitrov GP. Medical radiology. 1972;(7):77 (In Russ.)
6. Kapitsa SP, Melekhin VN. Microtron. Moscow. 1969 (In Russ.)
7. Cancer treatment. Report of the WHO Expert Committee. Moscow. 1967 (In Russ.)
8. Ruderman AI. Oncology issues. 1968;(6):20 (In Russ.)
9. Ruderman AI, Yarmonenko SP, Astrakhan BV et al. Bulletin of the USSR Academy of Medical Sciences. 1971; 3:38 (In Russ.)
10. Monzul GD, Gladilina IA. Use of heavy charged particles (protons) in oncology. 35 years of clinical experience of the State Institution Russian Cancer Research Center named after. N.N. Blokhin RAMS. Radiation biology. Radioecology. 2005;6:670-4 (In Russ.)
11. Monzul GD, Gladilina IA, Tkachev SI. Proton medical centers. Current state of the issue. XI International meeting on the use of charged particle accelerators in industry and medicine. St. Petersburg. 2005 (In Russ.)
12. Monzul GD, Gladilina IA, Tkachev SI. Medical proton complexes of Japan. Medical Physics. 2005;(1):82-6 (In Russ.)
13. Monzul GD, Gladilina IA. Proton therapy of malignant neoplasms (based on PTCOG42 materials). Medical Physics (Rus) 2005;3:93-5 (In Russ.)
14. Monzul GD, Gladilina IA. Modern possibilities of cancer therapy using high-energy protons (35 years of experience of the Russian Cancer Research Center). Proceedings of the conference ͞Physical and technical problems of quality assurance of radiation therapy.͟ 2006:104-5. (In Russ.)
15. Monzul GD, Gladilina IA. Proton therapy in the treatment of patients with skin melanoma. Proceedings of the conference ͞Unconventional dose fractionation in radiation and combined treatment of malignant neoplasms (25 years of experience).͟ Obninsk 2008:81-2. (In Russ.)
16. Monzul GD, Gladilina IA, Tkachev SI. Proton radiationtherapy for primary breast cancer. Materials of the III All-Russian National Congress of Radiation Diagnosticians and Therapists ͞Radiology 2009͟ Moscow. 2009:208-9 (In Russ.)
17.
Review
For citations:
Gladilina I.A., Lebedenko I.M., Chernykh M.V., Sukhova E.A. History of Development and Achievements of the Institute of Experimental and Clinical Oncology in Proton Radiotherapy. Journal of oncology: diagnostic radiology and radiotherapy. 2025;8(1):19-28. (In Russ.) https://doi.org/10.37174/2587-7593-2025-8-1-19-28