Preview

Journal of oncology: diagnostic radiology and radiotherapy

Advanced search

Klatskin Tumor: Difficulties in Diagnosis and Preoperative Staging. Clinical Observation

https://doi.org/10.37174/2587-7593-2023-6-1-71-79

Abstract

Klatskin’s tumor is  a  rare  malignant neoplasm characterized by  the  absence of  specific   symptoms, challenges in verification and  difficulties in assessing the  true extent  of the  tumor. We present a clinical case  of a patient with  hilar  cholangiocarcinoma. The  patient received  almost the  entire modern complex of  radiologic examinations  for  preoperative  staging.  However,   concominant  cholangitis, hard-to-reach anatomical localization and tumor’s  creeping-growth distorted the results of instrumental studies. The true volume of the lesion was detected only intraoperatively and resulted in an expansion of liver resection volume.

About the Authors

A. S. Turlak
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



A. V. Kozlov
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



P. G. Tarazov
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



A. A. Polikarpov
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



S. A. Popov
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



D. A. Granov
Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation

70, Leningradskaya str., Pesochny settlment, Saint Petersburg, 197758


Competing Interests:

Not declared



References

1. Dondossola D, Ghidini M, Grossi F, et al. Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma. World J Gastroenterol. 2020;26 (25):3542-61. DOI: 10.3748/wjg.v26.i25.3542

2. Zhang X, Liu H. Klatskin tumor: A population-based study of incidence and survival. Med Sci Monit. 2019;25:4503-12. DOI: 10.12659/msm.914987

3. Malignant neoplasms in Russia in 2020 (morbidity and mortality) Moscow, 2021 (In Russian).

4. Sapisochin G, Ivanics T, Subramanian V, et al. Multidisciplinary treatment for hilar and intrahepatic cholangiocarcinoma: A review of the general principles. Int J Surg. 2020;82S:77-81. DOI: 10.1016/j.ijsu.2020.04.067.

5. Cillo U, Fondevila C, Donadon M, et al. Surgery for cholangiocarcinoma. Liver Int. 2019;1:143-55. DOI: 10.1111/liv.14089.

6. Lee DH, Kim B, Lee ES, et al. Radiologic evaluation and structured reporting form for extrahepatic bile duct cancer: 2019 Consensus Recommendations from the Korean Society of Abdominal Radiology. Korean J Radiol. 2021;22(1):41-62. DOI: 10.3348/kjr.2019.0803.

7. Hewitt DB, Brown ZJ, Pawlik TM. Current perspectives on the surgical management of perihilar chol angiocarcinoma. Cancers (Basel). 2022;14(9):2208. DOI: 10.3390/cancers14092208.

8. Alieva SB, Bazin IS, Breder VV, et al. Clinical Guidelines: Cancer of the Biliary System. Moscow; 2020: 37. (In Russian).

9. Liu J, Ren WX, Shu J. Multimodal molecular imaging evaluation for early diagnosis and prognosis of cholangiocarcinoma. Insights Imaging. 2022;13(1):10. DOI: 10.1186/s13244-021-01147-7.

10. Kashtanova NY, Pletnyova VY, Gepalova YY. A modern view on the problem of diagnosing Klatskin’s tumor (review). Medical imaging. 2016;(6):52-61. (In Russian).

11. Frantsev DY, Sergeeva ON, Dolgushin BI. Therapy for hilar cholangiocarcinoma. Siberian Journal of Oncology. 2019;18 (1):103-15. (In Russian). DOI: 10.21294/1814-4861-2019-18-1-103-115

12. Wang GX, Ge XD, Zhang D, et al. MRCP combined with CT promotes the differentiation of benign and malignant distal bile duct strictures. Front Oncol. 2021;11:683869. DOI: 10.3389/fonc.2021.683869.

13. Kim SJ, Lee SW. Diagnostic accuracy of 18F-FDG PET/CT for detection of peritoneal carcinomatosis; a systematic review and meta-analysis. Br J Radiol. 2018;91:20170519. DOI: 10.1259/bjr.20170519.

14. Kiefer LS, Sekler J, Gückel B, et al. Impact of 18F-FDG-PET/CT on clinical management in patients with cholangiocellular carcinoma. BJR Open. 2021;5;3 (1):20210008. DOI: 10.1259/bjro.20210008.

15. Agrawal A, Purandare N, Shah S, et al. PET/CT in Hepatobiliary and Pancreatic Malignancies: PET/ CT in Gall Bladder and Biliary Tract Malignancies. 2017. 75–84. DOI: 10.1007/978-3-319-60507-4_8.

16. Hoyos S, Navas MC, Restrepo JC, et al. Current controversies in cholangiocarcinoma. Biochimica et Biophysica Acta. Molecular Basis of Disease. 2018;1864:1461-7. DOI: /10.1016/j.bbadis.2017.07.027.

17. Kovalenko YuA, Olifir AA, Pozharskaya AA, Zharikov YuO. Biopsy in hilar cholangiocarcinoma: diagnostics and modern possibilities of creating a preoperative prognosis system. Modern Medicine. 2018;2(10):198-200. (In Russian).

18. Kozlov AV, Tarazov PG, Polikarpov AA, et al. Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2022;32(2):45-54. (In Russian). DOI: 10.22416/1382-4376-2022-32-2-45-54.

19. Koerkamp B, Wiggers JK, Allen PJ, et al. Recurrence rate and pattern of perihilar cholangiocarcinoma after curative intent resection. J Am Coll Surg. 2015;221:1041-9. DOI: 10.1016/j.jamcollsurg.2015.09.005.

20. Capobianco I, Rolinger J, Nadalin S. Resection for Klatskin tumors: technical complexities and results. Transl Gastroenterol Hepatol. 2018;3:69. DOI: 10.21037/tgh.2018.09.01.

21. Zhang XF, Beal EW, Chakedis J, et al. Defining early recurrence of hilar cholangiocarcinoma after curative-intent surgery: A multi-institutional study from the US Extrahepatic Biliary Malignancy Consortium. World J Surg. 2018;42 (9):2919-29. DOI: 10.1007/s00268-018-4530-0.


Review

For citations:


Turlak A.S., Kozlov A.V., Tarazov P.G., Polikarpov A.A., Popov S.A., Granov D.A. Klatskin Tumor: Difficulties in Diagnosis and Preoperative Staging. Clinical Observation. Journal of oncology: diagnostic radiology and radiotherapy. 2023;6(1):71-79. (In Russ.) https://doi.org/10.37174/2587-7593-2023-6-1-71-79

Views: 752


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2587-7593 (Print)
ISSN 2713-167X (Online)