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Neoadjuvant Endobiliary Photodynamic Therapy in Klatskin Tumor Patients before Resection. First Experience

https://doi.org/10.37174/2587-7593-2022-5-3-70-77

Abstract

   Complete liver and bile ducts resection with negative margins (R0) in the only possible radical treatment of Klatskin tumor. Even after R0 resection, the recurrence rate is as high as 50–76 %. Neoadjuvant endobiliary photodynamic therapy (PDT) may potentially improve their results and long­term survival. The authors present their own first experience of endobiliary PDT performing before liver and bile ducts resection (R0) in Klatskin tumor patient.

About the Authors

D. Yu. Frantsev
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



E. R. Virshke
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



I. V. Pogrebnyakov
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



E. A. Nasonova
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



S. M. Abdulkarimova
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



A. N. Polyakov
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



D. V. Podluzhny
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



N. E. Kudashkin
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



E. A. Moroz
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



M. E. Timofeev
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



B. I. Dolgushin
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation

115478

24 Kashirskoye Highway

Moscow



References

1. Groot Koerkamp B., Wiggers J. K., Allen P. J., et al. Recurrence Rate and Pattern of Perihilar Cholangiocarcinoma after Curative Intent Resection. J Am Coll Surg. 2015 Dec; 221 (6): 1041­9. DOI: 10.1016/j.jamcollsurg.2015.09.005.

2. Jarnagin W. R., Ruo L., Little S. A., et al. Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies. Cancer. 2003 Oct 15; 98 (8): 1689­700. DOI: 10.1002/cncr.11699

3. Molina V., Sampson J., Ferrer J., et al. Klatskin tumor: Diagnosis, preoperative evaluation and surgical considerations. Cir Esp. 2015 Nov; 93 (9): 552­60. English, Spanish. DOI: 10.1016/j.ciresp.2015.07.003.

4. Soares K. C., Kamel I., Cosgrove D. P., et al. Hilar cholangiocarcinoma: diagnosis, treatment options, and management. Hepatobiliary Surg Nutr. 2014 Feb; 3 (1): 18­34. DOI: 10.3978/j.issn.2304-3881.2014.02.05.

5. Долгушин Б. И. Внутрипротоковая фотодинамическая терапия при воротной холангиокарциноме у неоперабельных больных / Б. И. Долгушин [и др.] // Анналы хирургической гепатологии. – 2016. – 21 (3): 106­18. [Dolgushin B. I., Sergeeva O. N., Frantsev D. Y., et al. Intraductal Photodynamic Therapy of Hilar Cholangiocarcinoma in Inoperable Patients. Annals of Surgical Hepatology. 2016; 21 (3): 106­-18. (In Russian)].

6. Францев Д. Ю. Лечение гилюсной холангиокарциномы. Современное состояние вопроса / Д. Ю. Францев, О. Н. Сергеева, Б. И. Долгушин // Сибирский онкологический журнал. – 2019. – 18 (1): 103­15. [Frantsev D. Yu., Sergeeva O. N., Dolgushin B. I. Therapy for hilar cholangiocarcinoma. Siberian Journal of Oncology. 2019; 18 (1): 103­15. (In Russian)]. URL: https://cyberleninka.ru/article/n/lechenie-gilyusnoy-holangiokartsinomy?ysclid=l8ctpwdtu116474656

7. Tzerkovsky D. A. Multiple­field interstitial photodynamic therapy of subcutaneously transplanted cholangiocellular carcinoma RS­1 in rats. Exp Oncol. 2017 Jul; 39 (2): 117­20. PMID: 29483499.

8. Wang J. B., Liu L. X., Pan SH, et al. Therapeutic effect of photodynamic therapy using hematoporphyrin monomethyl ether (HMME) on human cholangiocarcinoma cell line QBC939. Neoplasma. 2010; 57 (1): 79­85. DOI: 10.4149/neo_2010_01_079.

9. Kim C. H., Chung C. W., Choi K. H., et al. Effect of 5­aminolevulinic acid­based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells. Int J Nanomedicine. 2011; 6: 1357­63. DOI: 10.2147/IJN.S21395.

10. Sergeeva O., Frantsev D., Shorikov M., et al. Endobiliary photodynamic therapy in hilar cholangiocarcinoma patients after non­curative liver and bile duct resections: initial results(e­poster). The 7 th Asian Congress of Abdominal Radiology and the 20 th Chinese Congress of Abdominal Radiology (ACAR 2019 & CCAR 2019), May 23­26, 2019, Chengdu, China.

11. Nanashima A., Yamaguchi H., Shibasaki S., et al. Adjuvant photodynamic therapy for bile duct carcinoma after surgery: a preliminary study. J Gastroenterol. 2004 Nov; 39 (11): 1095­101. DOI: 10.1007/s00535-004-1449-z.

12. Wagner A., Wiedmann M., Tannapfel A., et al. Neoadjuvant Down­Sizing of Hilar Cholangio carcinoma with Photodynamic Therapy — Long­ Term Outcome of a Phase II Pilot Study. Int J Mol Sci. 2015 Nov 6; 16 (11): 26619­28. DOI: 10.3390/ijms161125978.

13. Kasuya K., Oka K., Soya R., et al. Photodynamic therapy for biliary tract organ via a novel ultra­small composite optical fiberscope. Exp Ther Med. 2017 Nov; 14 (5): 4344­8. DOI: 10.3892/etm.2017.5052.


Review

For citations:


Frantsev D.Yu., Virshke E.R., Pogrebnyakov I.V., Nasonova E.A., Abdulkarimova S.M., Polyakov A.N., Podluzhny D.V., Kudashkin N.E., Moroz E.A., Timofeev M.E., Dolgushin B.I. Neoadjuvant Endobiliary Photodynamic Therapy in Klatskin Tumor Patients before Resection. First Experience. Journal of oncology: diagnostic radiology and radiotherapy. 2022;5(3):70-77. (In Russ.) https://doi.org/10.37174/2587-7593-2022-5-3-70-77

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ISSN 2587-7593 (Print)
ISSN 2713-167X (Online)