Experimental Proof of Gadolinium Neutron Capture Therapy Antitumor Efficacy
https://doi.org/10.37174/2587-7593-2020-3-2-63-70
Abstract
Neutron capture therapy (NCT) is a promising method of curing cancer, which uses stable isotopes with large thermal neutron capture cross section value (a) to provide selective damage of a tumor. Boron isotope 10B (a = 3880 barn) is the most know and most widely used in NCT isotope. Gadolinium isotope 157Gd has even larger thermal neutron capture cross section value (σ = 254 000 barn) than 10B, but secondary radiation emitted by this isotope as the results of neutron capture nuclear reaction is absorbed by tumor tissues less effectively than for 10B.
The purpose of this research was to study gadolinium neutron capture therapy efficacy in curing spontaneous tumors.
13 dogs diagnosed with oral cavity spontaneous melanoma were studied. MRI contrast drug Dipentast® was used as a gadolinium containing substance. The drug was injected directly into the tumor immediately before neutron irradiation. The administered dose of the drug was 10 mg of gadolinium per 1 cm3 of tumor. The irradiation was made with thermal neutron beam with neutron flux 7x108 n/cm2s and 3-6 cm diameter. The duration of irradiation was 70 minutes.
As the results of the therapy complete tumor regression was achieved in 46 % of animals. Recurrence free period was 106.0±7.5 days for 66.7 % of dogs with complete tumor regression and more than 150 days for 16.7 %.
About the Authors
A. A. LipengoltsRussian Federation
24 Kashirskoye Highway, Moscow, 115478; 46 Zhivopisnaya str, Moscow, 123182; 31 Kashirskoye Highway, Moscow, 115409
Competing Interests: Not declared
A. M. Arnopolskaya
Russian Federation
31 Kashirskoye Highway, Moscow, 115409
Competing Interests: Not declared
I. N. Sheino
Russian Federation
46 Zhivopisnaya str, Moscow, 123182
Competing Interests: Not declared
V. N. Kulakov
Russian Federation
46 Zhivopisnaya str, Moscow, 123182
Competing Interests: Not declared
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Review
For citations:
Lipengolts A.A., Arnopolskaya A.M., Sheino I.N., Kulakov V.N. Experimental Proof of Gadolinium Neutron Capture Therapy Antitumor Efficacy. Journal of oncology: diagnostic radiology and radiotherapy. 2020;3(2):63-70. (In Russ.) https://doi.org/10.37174/2587-7593-2020-3-2-63-70