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Differential Diagnosis of Chronic Osteomyelitis in Manubrium of the Sternum in a Patient with Breast Cancer (Clinical Case)

https://doi.org/10.37174/2587-7593-2019-2-3-88-94

Abstract

Chronic osteomyelitis represents a progressive inflammatory process caused by pathogens, resulting in bone destruction and sequestrum formation.

A case of a 58-year-old woman with verified carcinoma of the left breast, which was treated in 2008-2009, is presented. In 2017, a focus suspicious of metastasis was detected in the left half of manubrium of the sternum by osteoscintigraphy. According to the changes in computed tomography and osteoscintigraphy, with ambiguous results of core biopsy, a decision to perform surgical treatment was made. A pathomorphological examination revealed chronic osteomyelitis of manubrium.

The case is interesting because of the complexity of the differential diagnosis of metastatic lesions in breast cancer and chronic osteomyelitis according to computed tomography.

About the Authors

R. Kh. Ulyanova
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



A. V. Mishchenko
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



A. V. Chernaya
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



A. B. Kosichkina
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



V. V. Danilov
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



А. A. Shipilova
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



M. I. Bisyarin
N.N. Petrov National Medical Research Oncology Center
Russian Federation

St. Petersburg



References

1. Parsons B., Strauss E. Surgical management of chronic osteomyelitis // Amer. J. Surg. 2004. Vol. 188. Suppl. 1A. P. 57-66.

2. Brady R.A., Leid J.G., Costerton J.W., Shirtliff M.E. Osteomyelitis: clinical overview and mechanisms of infection persistence // Clin. Microbiol. Newsl. 2006. Vol. 28. P. 65-72.

3. Panteli M., Giannoudis P. V. Chronic osteomyelitis: what the surgeon needs to know // EFORT Open Rev. 2016. Vol. 1. P. 128-135.

4. Hatzenbuehler J., Pulling T.J. Diagnosis and management of osteomyelitis // Amer. Fam. Physician. 2011. Vol. 84. P 1027-1033.

5. Cierny G., Mader J.T., Penninck J.J. A clinical staging system for adult osteomyelitis // Clin. Orthop. Relat. Res. 2003. Vol. 414. P 7-24.

6. Абаев Ю.К., Швед И.А., Клецкий С.К. Подострый и первично-хронический остеомиелит в детском возрасте // Вестник хирургии. 2005. № 4. C. 54-57.

7. Lorusso G., Ruegg C. New insights into the mechanisms of organ-specific breast cancer metastasis // Semin. Cancer Biol. 2012. Vol. 22. № 3. P. 226-233.

8. Glendenning J., Cook G. Imaging breast cancer bone metastases: current status and future directions // Semin. Nucl. Med. 2013. Vol. 43. № 4. P 317-323.

9. Lakhani S.R., Ellis I.O., Schnitt S.J. et al., eds. WHO classification of tumours of the breast. IARC / World Health Organization classification of tumours. - Lyon, France: WHO Press. 2012.

10. Stelmach A., Patla A., Skotnicki P, Sas-Korczynska B. Typical medullary breast carcinoma: Clinical outcomes and treatment results // Breast J. 2017. Vol. 23. № 6. P 770-771.

11. Веснин А.Г., Семенов И.И. Атлас лучевой диагностики опухолей опорно-двигательного аппарата: Часть 1: Опухоли скелета. - СПб.: «Невский диалект», 2002. 182 с.

12. O’Sullivan G.J., Carty F. L., Cronin C.G. Imaging of bone metastasis: An update // World J. Radiol. 2015. Vol. 7. № 8. P. 202-211.

13. Termaat M.F., Raijmakers P.G., Scholten H.J. et al. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis // J. Bone Joint Surg. 2005. Vol. 87. P. 2464-2471.

14. Santini-Araujo E., Kalil R.K., Bertoni F., Park Y.-K., eds. Tumors and Tumor-Like Lesions of Bone For Surgical Pathologists, Orthopedic Surgeons and Radiologists. -London: Springer-Verlag. 2015.

15. Lew D.P., Waldvogel F.A. Osteomyelitis // Lancet. 2004. Vol. 364. P. 369-379.

16. Macedo F., Ladeira K., Pinho F. et al. Bone metastases: an Overview // Oncol. Rev. 2017. Vol. 11. № 1. P. 43-49.

17. Lee Y. J., Sadigh S., Mankad K. et al. The imaging of osteomyelitis // Quant. Imaging Med. Surg. 2016. Vol. 6. № 2. P. 184-198.


Review

For citations:


Ulyanova R.Kh., Mishchenko A.V., Chernaya A.V., Kosichkina A.B., Danilov V.V., Shipilova А.A., Bisyarin M.I. Differential Diagnosis of Chronic Osteomyelitis in Manubrium of the Sternum in a Patient with Breast Cancer (Clinical Case). Journal of oncology: diagnostic radiology and radiotherapy. 2019;2(3):88-94. (In Russ.) https://doi.org/10.37174/2587-7593-2019-2-3-88-94

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ISSN 2587-7593 (Print)
ISSN 2713-167X (Online)