Stereotactic Body Radiation Therapy of Primary Tumor for Inoperable Non-Metastatic Differentiated Thyroid Carcinoma: a Case-Report
https://doi.org/10.37174/2587-7593-2026-9-1-97-102
Abstract
The main treatment methods for differentiated thyroid carcinoma are surgery and radioactive iodine ablation. In some cases, systemic therapy is useful. The use of external beam radiation therapy, especially stereotactic body radiation therapy applied with a curative intent, is highly debated. This article reports a rare clinical case of primary tumor treatment in a patient with inoperable differentiated thyroid carcinoma using stereotactic body radiation therapy and reviews the world data on the issue.
About the Authors
I. F. Zalyalov
European Medical Center PJC
Russian Federation
Competing Interests:
Russian Federation
26 Durova str., Moscow 129090
Competing Interests:
Not declared.
K. T. Galaeva
European Medical Center PJC
Russian Federation
Competing Interests:
Russian Federation
26 Durova str., Moscow 129090
Competing Interests:
Not declared.
References
1. Shank JB, Are C, Wenos CD. Thyroid Cancer: Global Burden and Trends. Indian Journal of Surgical Oncology. 2021;13(1):40-45. https://doi.org/10.1007/s13193-021-01429-y. PMID: 35462648.
2. Hansen EK, Roach M. Handbook of Evidence-Based Radiation Oncology. Springer; 2018.
3. Devita VT, Lawrence TS, Rosenberg SA. Devita, Hellman, and Rosen berg’s cancer: principles et practice of oncology. Philadelphia: Wolters Kluwer; 2015.
4. Kaprin AD, Starinskiy VV, Shakhzadova AO. The State of Cancer Care in Russia in 2024. – Moscow: PA Herzen Moscow Oncology Research Institute – the Branch of the National Medical Research Radiological Centre of the Ministry of Health; 2025. (In Russ.).
5. Differentiated thyroid carcinoma [Internet]. Clinical guidelines. 2024. Accessed 09.09.2025. Available from: https://cr.minzdrav.gov.ru/view-cr/329_2.
6. Cancer Today [Internet]. IARC – International Agency for Research on Cancer. Accessed 09.09.2025. Available from: https://gco.iarc.who.int/today/en/dataviz/maps-heatmap?mode=population&cancers=32&m-ap_nb_color=8&palette=Greys&key=crude_rate&age_end=14.
7. Timmerman R. A Story of Hypofractionation and the Table on the Wall. International Journal of Radiation Oncology*Biology*Physics. 2022;112(1):4-21. https://doi.org/10.1016/j.ijrobp.2021.09.027. PMID: 34919882.
8. Kiess AP, Agrawal N, Brierley JD, et al. External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. Head & Neck. 2015;38(4):493-8. https://doi.org/10.1002/hed.24357. PMID: 26716601.
9. Nair LM, Ravikumar R, Rafi M, et al. External Beam Radiotherapy in Differentiated Thyroid Cancer. IntechOpen eBooks. Published online November 28, 2022. https://doi.org/10.5772/intechopen.108466.
10. Joiner M, Van A. Basic Clinical Radiobiology. Crc Press/Taylor & Francis Group; 2019.
11. Michael Brent Bernstein, Chang EL, Amini B, et al. Spine Stereotactic Radiosurgery for Patients with Metastatic Thyroid Cancer: Secondary Analysis of Phase I/II Trials. Thyroid. 2016;26(9):1269-75. https://doi. org/10.1089/thy.2016.0046. PMID: 27334245.
12. Kaur S, Gui B, Ghaly M, Nagashree Seetharamu. Utilizing stereotactic body radiation therapy in combination with tyrosine kinase inhibitors for therapeutic benefit in thyroid cancer. Journal of Clinical Oncol ogy. 2024;42(16_suppl):e18065-e18065. https://doi.org/10.1200/jco.2024.42.16_suppl.e18065.
13. Buchberger DS, Dennert K, Campbell SR, et al. Definitive Radiothera py for the Treatment of Gross Disease in Unresected Differentiated Thyroid Cancer. International Journal of Radiation Oncology*Biol ogy*Physics. 2023;117(2):e568-e569. https://doi.org/10.1016/j.ijrobp.2023.06.1895. PMID: 30105947.
14. Gui B, Wuu YR, Kaur S, et al. Stereotactic Body Radiotherapy with Ty rosine Kinase Inhibitors for Refractory Locoregional Progression of Non-Anaplastic Thyroid Cancer. International Journal of Radiation Oncology*Biology*Physics. 2024;120(2):e755-e756. https://doi.org/10.1016/j.ijrobp.2024.07.1659.
15. Simontacchi G, Sparano C, Loi M, et al. The Role of Stereotac tic Radiotherapy in Deferring the Need for Systemic Thera pies in Patients with Progressive Oligometastatic Iodine-Re fractory Thyroid Cancer. International Journal of Radiation Oncology*Biology*Physics. 2023;117(2):e626-e626. https://doi.org/10.1016/j.ijrobp.2023.06.2015.
16. van den End JW, Jager EC, Verbeek HHG, et al. Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer. Head & Neck. Published online January 22, 2025. https://doi.org/10.1002/hed.28076. PMID: 39840437.
17.
Review
For citations:
Zalyalov I.F., Galaeva K.T. Stereotactic Body Radiation Therapy of Primary Tumor for Inoperable Non-Metastatic Differentiated Thyroid Carcinoma: a Case-Report. Journal of oncology: diagnostic radiology and radiotherapy. 2026;9(1):97-102. (In Russ.) https://doi.org/10.37174/2587-7593-2026-9-1-97-102
Views:
155
JATS XML
Email this article 