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Castleman’s Disease: General Information and Clinical Cases

https://doi.org/10.37174/2587-7593-2026-9-1-53-59

Abstract

The article presents two clinical cases of the local variant of Castleman’s disease in women aged 29 and 46. Both patients had no complaints, and pathological lesions in the abdominal cavity were revealed in routine US-examinations. In the first case, the preoperative contrast–enhanced CT scans with typical findings allowed us to make the correct diagnosis. In the second case, an atypical CT picture of the detected lesion did not allow us to specify the preoperative diagnosis. Both patients were successfully operated on, but in the second case with intraoperative technical difficulties. Based on the morphological examination of the removed lesions, the final diagnosis was made — Castleman’s disease (hyaline vascular type).

About the Authors

A. B. Lukyanchenko
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation

23 Kashirskoe highway, Moscow, 115522


Competing Interests:

Not declared.



Х. A. Romanova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation

23 Kashirskoe highway, Moscow, 115522


Competing Interests:

Not declared.



P. S. Kropotov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation

23 Kashirskoe highway, Moscow, 115522


Competing Interests:

Not declared.



E. B. Kodzoeva
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation

23 Kashirskoe highway, Moscow, 115522


Competing Interests:

Not declared.



I. S. Stilidi
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation

23 Kashirskoe highway, Moscow, 115522


Competing Interests:

Not declared.



References

1. Simpson D. Epidemiology of Castleman Disease. Hematol Oncol Clin North Am. 2018;32(1):1-10. https://doi.org/10.1016/j.hoc.2017.09.001. PMID: 29157611.

2. Yegorova EK. Clinical and morphological features of different variants of Castleman disease [dissertation]. Moscow: Hematology Research Center of the Russian Academy of Medical Sciences; 2016. 121 p. (In Russ.).

3. Rumyantsev AG, Maschan AA, et al. Federal clinical guidelines for the diagnosis and treatment of Castleman disease in children. Moscow: GEOTAR-Media; 2015. 25 p. URL:http://nodgo.org/sites/default/files/07_Болезнь_Кастлемана.pdf. (In Russ.).

4. Melikyan AL, Yegorova EK. Castleman’s disease (literature review). Oncohematology. 2016;11(2):8-19. https://doi.org/10.17650/1818-8346-2016-11-2-8-20. (In Russ.).

5. Pechetov АА, Karmazanovsky GG, Smirnov AV. Castleman’s disease. Surgery N.I. Pirogova Journal. 2014;(4):65-9. (In Russ.). https://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-pirogova/2014/4/030023-12072014415.

6. Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control. 2014,21(4):266-78. https://doi.org/10.1177/107327481402100403. PMID: 25310208.

7. Ko SF, Hsieh MJ, Ng SH, et al. Imaging spectrum of Castleman’s disease. AJR Am J Roentgenol. 2004;182(3):769-75. https://doi.org/10.2214/ajr.182.3.1820769. PMID: 14975984.

8. Yoshizaki K, Matsuda T, Nishimoto N, et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease. Blood. 1989;74(4):1360-67. https://doi.org/10.2214/ajr.182.3.1820769. PMID: 2788466.

9. Suda T, Katano H, Delsol G, et al. HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman’s disease. Pathol Int. 2001;51(9):671-9. https://doi.org/10.1046/j.1440-1827.2001.01266.x. PMID: 11696169.

10. Chronowski GM, Ha CS, Wilder RB, et al. Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy. Cancer. 2001;92(3):670-6. https://doi.org/10.1002/1097-0142(20010801)92:3%3C670::aid-cncr1369%3E3.0.co;2-q. PMID: 11505414.

11. Miranda FA, Faria VH, Arruda GV, et al. Radiation therapy in the treatment of unicentric Castleman’s disease. J Bras Pneumol. 2013;39(1):116-8. https://doi.org/10.1590/s1806-37132013000100019. PMID: 23503497; PMCID: PMC4075797

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For citations:


Lukyanchenko A.B., Romanova Х.A., Kropotov P.S., Kodzoeva E.B., Stilidi I.S. Castleman’s Disease: General Information and Clinical Cases. Journal of oncology: diagnostic radiology and radiotherapy. 2026;9(1):53-59. (In Russ.) https://doi.org/10.37174/2587-7593-2026-9-1-53-59

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ISSN 2587-7593 (Print)
ISSN 2713-167X (Online)