Progressive Multifocal Leukoencephalopathy: Literature Review and Clinical Case Study
https://doi.org/10.37174/2587-7593-2024-7-4-54-61
Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, primarily affecting individuals with severe immunosuppression. Its subacute onset, nonspecific clinical manifestations, and MRI findings complicate accurate and timely diagnosis. This review provides a brief overview of the etiology and fundamental pathogenesis of the disease, demonstrating through a clinical case the importance of a multimodal approach and the potential challenges in the differential diagnosis of PML.
About the Authors
K. V. Golanova
Center for Diagnostics and Telemedicine
Russian Federation
Competing Interests:
Russian Federation
Kristina V. Golanova
24, bld. 1, Petrovka str., Moscow, Russia 127051
Competing Interests:
Conflict of interests. Not declared
D. V. Sashin
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
E. A. Nechipay
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
N. V. Garanina
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
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Review
For citations:
Golanova K.V., Sashin D.V., Nechipay E.A., Garanina N.V. Progressive Multifocal Leukoencephalopathy: Literature Review and Clinical Case Study. Journal of oncology: diagnostic radiology and radiotherapy. 2024;7(4):54-61. (In Russ.) https://doi.org/10.37174/2587-7593-2024-7-4-54-61
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