Glial Brain Tumors BNCT Treatment Efficacy. A Systematic Review
https://doi.org/10.37174/2587-7593-2024-7-4-13-18
Abstract
Purpose: Boron neutron capture therapy is a promising and prospective treatment method, including patients with high-grade glial brain tumors. Taking into account the planned bringing into service of a neutron source accelerator at the N.N. Blokhin National Medical Research Center of Oncology, the objective of the review was to update the current status of the effectiveness of a prospective treatment method.
Material and methods: A literature search was conducted to identify results of retrospective (with at least 30 patients analyzed) and phase I and II studies in the Pubmed database.
Results: Of the 58 publications found, 8 papers met the search criteria: a retrospective study, 5 phase I studies, and 2 articles with the results of phase II studies. An analysis of these works indicates a low level of methodology for conducting clinical studies of the BNCT effectiveness thus impossibility to recommend the method for routine practice.
Conclusion: Clinical trials with an appropriate level of methodology are required to recommend BNCT for patients with high-grade glial brain tumors as a standard treatment.
About the Authors
V. A. Ivanov
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
Valerii A. Ivanov
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
M. V. Chernykh
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
T. G. Gevorkyan
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
24 Kashirskoe Shosse, Moscow, Russia 115478
Competing Interests:
Conflict of interests. Not declared
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Review
For citations:
Ivanov V.A., Chernykh M.V., Gevorkyan T.G. Glial Brain Tumors BNCT Treatment Efficacy. A Systematic Review. Journal of oncology: diagnostic radiology and radiotherapy. 2024;7(4):13-18. (In Russ.) https://doi.org/10.37174/2587-7593-2024-7-4-13-18
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