Pseudolesions of the Liver According to PET/CT with 18F-FDG and Other Imaging Techniques for Hodgkin’s Lymphoma
https://doi.org/10.37174/2587-7593-2026-9-2-28-36
Abstract
In most cases, the detection of focal liver changes in patients with systemic lymphoproliferative disease by imaging methods is associated in the mind of a radiologist with organ damage, which, accordingly, significantly affects the determination of the stage and treatment strategy. The PET/CT method is recognized as the most informative in determining the prevalence of the pathological process in Hodgkin’s lymphoma [1]. When determining the nature of focal changes in the liver parenchyma, the diagnostician is faced with the need to differentiate organ damage by a systemic process from pseudolesions. The picture of these processes in ultrasound (ultrasound), computed tomography (CT), and magnetic resonance imaging (MRI) has been studied for a long time, and data on the capabilities of PET/CT in combination with other imaging methods have not been sufficiently studied.
Purpose. To introduce colleagues to a special type of selective accumulation of 18F-FDG in the liver, a trap that can become a source of misinterpretation and compare PET data with other imaging methods.
Keywords
About the Authors
E. V. Rozengauz
A.M. Granov Russian Research Center of Radiology and Surgical Technologies; I.I. Mechnikov North-Western State Medical University
Russian Federation
Competing Interests:
Russian Federation
Evgeny V. Rozengauz
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
41 Kirochnaya Str., Saint Petersburg, 191015
Competing Interests:
The authors declare no conflict of interest
A. L. Dolbov
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation
Competing Interests:
Russian Federation
Artyom L. Dolbov
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
+79112900619
Competing Interests:
The authors declare no conflict of interest
N. V. Ilyin
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation
Competing Interests:
Russian Federation
Nikolay V. Ilyin
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
Competing Interests:
The authors declare no conflict of interest
M. Yu. Golovtsova
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation
Competing Interests:
Russian Federation
Marianna Yu. Golovtsova
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
Competing Interests:
The authors declare no conflict of interest
E. N. Shelkoplyas
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation
Competing Interests:
Russian Federation
Elina N. Shelkoplyas
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
Competing Interests:
The authors declare no conflict of interest
A. A. Khomenko
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Russian Federation
Competing Interests:
Russian Federation
Anton A. Khomenko
70 Leningradskaya Str., Pesochny, Saint Petersburg, 197758
Competing Interests:
The authors declare no conflict of interest
References
1. Hodgkin’s lymphoma. Clinical recommendations. The Association of Oncologists of Russia, the Russian Society of Hematology, the Russian Society of Clinical Oncology (RUSSCO), the National Hematology Society. Moscow, 2024. ID: 139_2024
2. Burrowes DP, Medellin A, Harris AC, et al, Characterization of Focal Liver Masses: A Multicenter Comparison of Contrast-Enhanced Ultrasound, Computed Tomography, and Magnetic Resonance Imaging. J Ultrasound Med. 2021;40(12):2581-93. https://doi.org/10.1002/jum.15644
3. Rosengauz EV. Liver pseudoformations according to the data of multilayer spiral computed tomography. Medical imaging. 2006;1:8-21. (In Russ.).
4. Desser TS. Understanding transient hepatic attenuation differences. Semin Ultrasound CT MR. 2009;30(5):408-417. https://doi.org/10.1053/j.sult.2009.07.003).
5. Bhatnagar G, Sidhu HS, Vardhanabhuti V, et al. The varied sonographic appearances of focal fatty liver disease: review and diagnostic algorithm. Clin Radiol. 2012;67(4):372-9. https://doi.org/10.1016/j.crad.2011.10.020
6. Kobayashi S. Hepatic pseudolesions caused by alterations in intrahepatic hemodynamics. World J Gastroenterol. 2021;27(46):7894-7908. https://doi.org/10.3748/wjg.v27.i46.7894
7. Deger S, Bozer A. Liver Pseudotumor Due to Aberrant Left Gastric Vein: A Case Report. J Belg Soc Radiol. 2023;107(1):82. https://doi.org/10.5334/jbsr.3342. PMID: 37900346; PMCID: PMC10607559.
8. Jain A, Ablett M. Pseudolesion caused by aberrant venous drainage / Clinical Cases / www.eurorad.org/case/7101, https://doi.org/10.1594/EURORAD/CASE.7101
9. Sollaku S, Frantellizzi V, Casciani E, et al. The rare case of positive FDG-positron emission tomography for giant cavernous hemangioma of the liver. Br J Res. 2017;4:19. https://doi.org/10.21767/2394-3718.100019
10. Kurtaran A, Becherer A, Pfeffel F, et al. 18F-fluorodeoxyglucose (FDG)-PET features of focal nodular hyperplasia (FNH) of the liver. Liver. 2000;20(6):487-90. https://doi.org/10.1034/j.1600-0676.2000.020006487.x
11. Maldjian PD, Obolevich AT, Cho KC. Focal enhancement of the liver on CT: a sign of SVC obstruction. J Comput Assist Tomogr. 1995;19:316-18 https://doi.org/10.1016/j.clinre.2014.03.008
12. Virmani V, Lal A, Ahuja CK, Khandelwal N. The CT Quadrate lobe hot spot sign. Ann Hepatol. 2010;9(3):296-8. https://doi.org/10.15171/mejdd.2018.110
13. Yamada T, Takahashi K, Shuke N, et al. Focal hepatic hot spot on superior vena cava obstruction: correlation between radiocolloid hepatic SPECT and contrast enhanced CT Clin Nucl Med. 1999:533-4. https://doi.org/10.1097/00003072-199907000-00019
14. Maldjian PD, Ghesani N. Focal increased activity in the liver on 18F-FDG PET scan secondary to brachiocephalic vein and superior vena cava obstruction. J Thorac Imaging. 2008;23(4):275-7. https://doi.org/10.1097/RTI.0b013e3181804763
Review
For citations:
Rozengauz E.V., Dolbov A.L., Ilyin N.V., Golovtsova M.Yu., Shelkoplyas E.N., Khomenko A.A. Pseudolesions of the Liver According to PET/CT with 18F-FDG and Other Imaging Techniques for Hodgkin’s Lymphoma. Journal of oncology: diagnostic radiology and radiotherapy. 2026;9(2):28-36. (In Russ.) https://doi.org/10.37174/2587-7593-2026-9-2-28-36
Views:
70
JATS XML
Email this article 