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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ojrdrt</journal-id><journal-title-group><journal-title xml:lang="ru">Онкологический журнал: лучевая диагностика, лучевая терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of oncology: diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7593</issn><issn pub-type="epub">2713-167X</issn><publisher><publisher-name>НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37174/2587-7593-2018-1-4-14-33</article-id><article-id custom-type="elpub" pub-id-type="custom">ojrdrt-77</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛУЧЕВАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RADIOTHERAPY</subject></subj-group></article-categories><title-group><article-title>Протонная лучевая терапия: современное состояние и перспективы. Часть I. Физико-технические основы</article-title><trans-title-group xml:lang="en"><trans-title>Proton Radiotherapy: Current Status and Future Prospects. Part 1. Physical and Technical Aspects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климанов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimanov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галяутдинова</surname><given-names>Ж. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Galjautdinova</surname><given-names>J. J.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Забелин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zabelin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России;&#13;
Национальный исследовательский ядерный университет «МИФИ»;&#13;
Московский государственный университет им. М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Burnazyan Federal Medical Biophysical Center;&#13;
National Research Nuclear University MEPhI;&#13;
M.V. Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Burnazyan Federal Medical Biophysical Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2018</year></pub-date><volume>1</volume><issue>4</issue><fpage>14</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Климанов В.А., Галяутдинова Ж.Ж., Забелин М.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Климанов В.А., Галяутдинова Ж.Ж., Забелин М.В.</copyright-holder><copyright-holder xml:lang="en">Klimanov V.A., Galjautdinova J.J., Zabelin M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.oncoradjournal.ru/jour/article/view/77">https://www.oncoradjournal.ru/jour/article/view/77</self-uri><abstract><p>Приведен аналитический обзор современного состояния протонной терапии в мире и в России и перспективных разработок в области ускорительной техники, технологий доставки дозы к мишени, методов расчета дозы, относительной биологической эффективности протонного облучения. Дано краткое описание особенностей взаимодействия протонов с веществом, которое используется для объяснения отличительных особенностей протонной терапии по сравнению с другими способами лучевого лечения.</p></abstract><trans-abstract xml:lang="en"><p>The work represents an analytical review of current status of proton therapy in the world and in Russia and advanced developments in the field of accelerator technology, dose delivery technology to target, methods of dose calculating. The main sections of the article are preceded by a brief description of the interactions of protons with the matter, which is then used to explain the distinctive features of proton therapy compared with other options of radiation treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лучевая терапия</kwd><kwd>циклотроны</kwd><kwd>синхротроны</kwd><kwd>протоны</kwd><kwd>фотоны</kwd><kwd>методы расчета дозы</kwd><kwd>тонкий луч</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radiation therapy</kwd><kwd>cyclotron</kwd><kwd>synchrotron</kwd><kwd>protons</kwd><kwd>photons</kwd><kwd>relative biological effectiveness</kwd><kwd>methods for dose calculating</kwd><kwd>a pencil beam</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Janni J. F. Proton range energy tables, 1 keV–10 GeV Atomic Data // Nucl. Data Tables. 1982. Vol. 27. P. 147– 529.</mixed-citation><mixed-citation xml:lang="en">Janni J. F. Proton range energy tables, 1 keV–10 GeV Atomic Data // Nucl. Data Tables. 1982. Vol. 27. P. 147– 529.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Paganetti H. Relative biological effectiveness (RBE) values for proton beam therapy variations as a function of biological endpoint, dose and linear energy transfer // Phys. Med. Biol. Vol. 59. 2014. P. R419–R472.</mixed-citation><mixed-citation xml:lang="en">Paganetti H. Relative biological effectiveness (RBE) values for proton beam therapy variations as a function of biological endpoint, dose and linear energy transfer // Phys. Med. Biol. Vol. 59. 2014. P. R419–R472.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">https://www.oncolink.org/cancer-treatment/protontherapy/overviews-of-proton-therapy/ocularmelanomaand-proton-therapy.</mixed-citation><mixed-citation xml:lang="en">https://www.oncolink.org/cancer-treatment/protontherapy/overviews-of-proton-therapy/ocularmelanomaand-proton-therapy.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Damato B. Developments in the management of uveal melanoma // Clin. Exper. Ophthalmol. 2004. Vol. 32. P. 639–647.</mixed-citation><mixed-citation xml:lang="en">Damato B. Developments in the management of uveal melanoma // Clin. Exper. Ophthalmol. 2004. Vol. 32. P. 639–647.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Мицын Г.В., Ольшевский А.Г., Сыресин Е.М. Протонная терапия сегодня и завтра // Еженедельник ОИЯИ «Дубна». 2008. № 32.</mixed-citation><mixed-citation xml:lang="en">Мицын Г.В., Ольшевский А.Г., Сыресин Е.М. Протонная терапия сегодня и завтра // Еженедельник ОИЯИ «Дубна». 2008. № 32.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goitein G.P. Proton Radiation Therapy of Ocular Melanom. Teaching Course 2010 OPTIS PTCOG 49. 2010.</mixed-citation><mixed-citation xml:lang="en">Goitein G.P. Proton Radiation Therapy of Ocular Melanom. Teaching Course 2010 OPTIS PTCOG 49. 2010.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Noel G., Bollet M.A., Calugaru V. et al. Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons // Int. J. Radiat. Oncol. Biol. Phys. 2005.Vol. 62. № 5. P. 1412–1422.</mixed-citation><mixed-citation xml:lang="en">Noel G., Bollet M.A., Calugaru V. et al. Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons // Int. J. Radiat. Oncol. Biol. Phys. 2005.Vol. 62. № 5. P. 1412–1422.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wenkel E., Thornton A.F., Finkelstein D. et al. Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy // Int. J. Radiat. Oncol. Biol. Phys. 2000. Vol. 48. № 5. P. 1363–1370.</mixed-citation><mixed-citation xml:lang="en">Wenkel E., Thornton A.F., Finkelstein D. et al. Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy // Int. J. Radiat. Oncol. Biol. Phys. 2000. Vol. 48. № 5. P. 1363–1370.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vernimmen L.K. et al. Stereotactic proton beam therapy of skull base meningiomas // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 49. № 1. P. 99–105.</mixed-citation><mixed-citation xml:lang="en">Vernimmen L.K. et al. Stereotactic proton beam therapy of skull base meningiomas // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 49. № 1. P. 99–105.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Romb B., Vennarini S., Vinante L. et al. Proton radiotherapy for pediatric tumors: review of first clinical results // Ital. J. Pediatr. 2014. № 40. P. 74–78.</mixed-citation><mixed-citation xml:lang="en">Romb B., Vennarini S., Vinante L. et al. Proton radiotherapy for pediatric tumors: review of first clinical results // Ital. J. Pediatr. 2014. № 40. P. 74–78.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Robison L.L., Armstrong G.T., Boice J.D. et al. The childhood cancer survivor study: a National Cancer Institute-supported resource for outcome and intervention research // J. Clin. Oncol. 2009. Vol. 27. № 14. P. 2308–2318.</mixed-citation><mixed-citation xml:lang="en">Robison L.L., Armstrong G.T., Boice J.D. et al. The childhood cancer survivor study: a National Cancer Institute-supported resource for outcome and intervention research // J. Clin. Oncol. 2009. Vol. 27. № 14. P. 2308–2318.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ishida Y., Sakamoto N., Kamibeppu K. et al. Late effects and quality of life of childhood cancer survivors: part 2: impact of radiotherapy // Int. J. Hematol. 2010. Vol. 92. № 1. P. 95–104.</mixed-citation><mixed-citation xml:lang="en">Ishida Y., Sakamoto N., Kamibeppu K. et al. Late effects and quality of life of childhood cancer survivors: part 2: impact of radiotherapy // Int. J. Hematol. 2010. Vol. 92. № 1. P. 95–104.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer E.G., Welch K., Shillito J. et al. Craniopharyngioma in children: long-term effects of conservative surgical procedures combined with radiation therapy // J. Neurosurg. 1990. Vol. 73. № 4. P. 534–540.</mixed-citation><mixed-citation xml:lang="en">Fischer E.G., Welch K., Shillito J. et al. Craniopharyngioma in children: long-term effects of conservative surgical procedures combined with radiation therapy // J. Neurosurg. 1990. Vol. 73. № 4. P. 534–540.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schell M.J., McHaney V.A. et al. Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation // J. Clin. Oncol. 1989. Vol. 7. № 6. P. 754–760. Pubmed. 2715805.</mixed-citation><mixed-citation xml:lang="en">Schell M.J., McHaney V.A. et al. Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation // J. Clin. Oncol. 1989. Vol. 7. № 6. P. 754–760. Pubmed. 2715805.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Adan L., Trivin C. et al. GH deficiency caused by cranial irradiation during childhood: factors and markers in young adults // J. Clin. Endocrinol. &amp; Metabolism. 2001. Vol. 86. № 1. P. 5245–5251. Pubmed 11701685.</mixed-citation><mixed-citation xml:lang="en">Adan L., Trivin C. et al. GH deficiency caused by cranial irradiation during childhood: factors and markers in young adults // J. Clin. Endocrinol. &amp; Metabolism. 2001. Vol. 86. № 1. P. 5245–5251. Pubmed 11701685.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Schell M.J., McHaney V.A. et al. Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation // J. Clin. Oncol. 1989. Vol. 7. № 6. P. 754-760. Pubmed 2715805/</mixed-citation><mixed-citation xml:lang="en">Schell M.J., McHaney V.A. et al. Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation // J. Clin. Oncol. 1989. Vol. 7. № 6. P. 754-760. Pubmed 2715805/</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dores G.M., Metayer C. et al. Second malignant neoplasms among long-term survivors of Hodgkin’s disease: a population-based evaluation over 25 years // J. Clin. Oncol. 2002. Vol. 20. № 16. P. 3484–3494. Pubmed 12177110.</mixed-citation><mixed-citation xml:lang="en">Dores G.M., Metayer C. et al. Second malignant neoplasms among long-term survivors of Hodgkin’s disease: a population-based evaluation over 25 years // J. Clin. Oncol. 2002. Vol. 20. № 16. P. 3484–3494. Pubmed 12177110.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mulhern R.K., Palmer S.L. Neurocognitive late effects in pediatric cancer // Current Problems in Cancer. 2003. Vol. 27. № 4. P. 177–197. Pubmed 12855950.</mixed-citation><mixed-citation xml:lang="en">Mulhern R.K., Palmer S.L. Neurocognitive late effects in pediatric cancer // Current Problems in Cancer. 2003. Vol. 27. № 4. P. 177–197. Pubmed 12855950.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cotter S.E., McBride S.M., Yock T.I. Proton radiotherapy for solid tumors of childhood // Technol. Cancer Res. Treat. 2012. Vol. 11. № 3. P. 267–278.</mixed-citation><mixed-citation xml:lang="en">Cotter S.E., McBride S.M., Yock T.I. Proton radiotherapy for solid tumors of childhood // Technol. Cancer Res. Treat. 2012. Vol. 11. № 3. P. 267–278.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Clarke M., Collins R., Darby S. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials // Lancet. 2005. Vol. 366. № 9503. P. 2087–2106.</mixed-citation><mixed-citation xml:lang="en">Clarke M., Collins R., Darby S. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials // Lancet. 2005. Vol. 366. № 9503. P. 2087–2106.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Li J.S., Freedman G.M., Price R. et al. Clinical implementation of intensity-modulated tangential beam irradiation for breast cancer // Med. Phys. 2004. Vol. 31. № 5. P. 1023–1031.</mixed-citation><mixed-citation xml:lang="en">Li J.S., Freedman G.M., Price R. et al. Clinical implementation of intensity-modulated tangential beam irradiation for breast cancer // Med. Phys. 2004. Vol. 31. № 5. P. 1023–1031.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Seidman A., Hudis C., Pierri M.K. et al. Cardiac dysfunction in the trastuzumab clinical trials experience // Clin. Oncol. 2002. Vol. 20. № 5. P. 1215–1221.</mixed-citation><mixed-citation xml:lang="en">Seidman A., Hudis C., Pierri M.K. et al. Cardiac dysfunction in the trastuzumab clinical trials experience // Clin. Oncol. 2002. Vol. 20. № 5. P. 1215–1221.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mantini G., Smaniotto D., Balducci M. Radiationinduced cardiovascular disease: impact of dose and volume // Rays. 2005. Vol. 30. № 2. P. 157–168.</mixed-citation><mixed-citation xml:lang="en">Mantini G., Smaniotto D., Balducci M. Radiationinduced cardiovascular disease: impact of dose and volume // Rays. 2005. Vol. 30. № 2. P. 157–168.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatnagar A.K., Brandner E., Sonnik D. et al. Intensitymodulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation: initial report // Cancer J. 2004. Vol. 10. P. 381–385.</mixed-citation><mixed-citation xml:lang="en">Bhatnagar A.K., Brandner E., Sonnik D. et al. Intensitymodulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation: initial report // Cancer J. 2004. Vol. 10. P. 381–385.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hall E.J. Intensity-modulated radiation therapy, protons, and the risk of second cancers // Int. J. Radiat. Oncol. Biol. Phys. 2006. Vol. 65. № 1. P. 1–7.</mixed-citation><mixed-citation xml:lang="en">Hall E.J. Intensity-modulated radiation therapy, protons, and the risk of second cancers // Int. J. Radiat. Oncol. Biol. Phys. 2006. Vol. 65. № 1. P. 1–7.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Burman C., Chui C.S. et al. Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for largescale implementation for the treatment of carcinoma of the prostate // Int. J. Radiat. Oncol. Biol. Phys. 1997. Vol. 39. № 4. P. 863–873.</mixed-citation><mixed-citation xml:lang="en">Burman C., Chui C.S. et al. Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for largescale implementation for the treatment of carcinoma of the prostate // Int. J. Radiat. Oncol. Biol. Phys. 1997. Vol. 39. № 4. P. 863–873.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Shipley W.U. et al. Proton radiation as boost therapy for localized prostatic carcinoma // JAMA. 1979. Vol. 241. № 18. P. 1912–1915.</mixed-citation><mixed-citation xml:lang="en">Shipley W.U. et al. Proton radiation as boost therapy for localized prostatic carcinoma // JAMA. 1979. Vol. 241. № 18. P. 1912–1915.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sejpal S., Komaki R., Tsao A. et al. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer // Cancer. 2011. Vol. 117. № 13. P. 3004–3013.</mixed-citation><mixed-citation xml:lang="en">Sejpal S., Komaki R., Tsao A. et al. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer // Cancer. 2011. Vol. 117. № 13. P. 3004–3013.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bradley J.D., Paulus R., Komaki R. et al. A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal chemoradiotherapy with or without cetuximab for stage III non-small cell lung cancer: Results on radiation dose in RTOG 0617 // Lancet Oncol. 2015. Vol. 16. № 2. P. 187–199.</mixed-citation><mixed-citation xml:lang="en">Bradley J.D., Paulus R., Komaki R. et al. A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal chemoradiotherapy with or without cetuximab for stage III non-small cell lung cancer: Results on radiation dose in RTOG 0617 // Lancet Oncol. 2015. Vol. 16. № 2. P. 187–199.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Goitein M., Cox J. Should randomized clinical trial be required for proton radiotherapy? // J. Clin. Oncol. 2008. Vol. 26. P. 175–176.</mixed-citation><mixed-citation xml:lang="en">Goitein M., Cox J. Should randomized clinical trial be required for proton radiotherapy? // J. Clin. Oncol. 2008. Vol. 26. P. 175–176.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Suit H. et al. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No // Radiother. Oncol. 2008. Vol. 86. P. 148– 153.</mixed-citation><mixed-citation xml:lang="en">Suit H. et al. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No // Radiother. Oncol. 2008. Vol. 86. P. 148– 153.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Cotter S.E., Herrup D.A., Friedmann A. et al. Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity modulated radiation therapy // Int. J. Radiat. Oncol. Biol. Phys. 2011. Vol. 81. P. 1367– 1373.</mixed-citation><mixed-citation xml:lang="en">Cotter S.E., Herrup D.A., Friedmann A. et al. Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity modulated radiation therapy // Int. J. Radiat. Oncol. Biol. Phys. 2011. Vol. 81. P. 1367– 1373.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Brodin N.P., Munck A.F., Rosensch P. et al. Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma // Acta Oncol. 2011. Vol. 50. P. 806–816.</mixed-citation><mixed-citation xml:lang="en">Brodin N.P., Munck A.F., Rosensch P. et al. Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma // Acta Oncol. 2011. Vol. 50. P. 806–816.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
