ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2026-9-1-16-23ojrdrt-508Research ArticleЯДЕРНАЯ МЕДИЦИНАNUCLEAR MEDICINEПЭТ/КТ с 68Ga-FAPI и 18F-FDG в оценке отдаленного метастатического поражения при раке желудкаPET/CT with 68Ga-FAPI and 18F-FDG in the Detection of Distant Metastases of Gastric Cancerhttps://orcid.org/0009-0009-0819-3891БелкинЕ. В.BelkinE. V.

115478 Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478 

ega.belkin@yandex.ruhttps://orcid.org/0000-0001-7226-5129ТулинП. Е.TulinP. E.

115478 Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478 

https://orcid.org/0009-0000-4807-5608БадеянА. М.BadeyanA. M.

Ереван, улица Алабяна, 38/7

38/7, Alabyana str., Yerevan

https://orcid.org/0000-0002-7045-0977Абу‑ХайдарО. Б.Abu‑KhaidarO. B.

115478 Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478 

https://orcid.org/0009-0007-6294-5826СоломяныйВ. В.SolomyanyyV. V.

115478 Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478 

https://orcid.org/0009-0001-6694-9564ФилимоновА. В.FilimonovA. V.

115478 Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478 

Национальный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationЦентр производства радиоизотопов Минздрава АрменииАрменияRadioisotope Production CentreArmenia202628032026911623Copyright © Белкин Е.В., Тулин П.Е., Бадеян А.М., Абу‑Хайдар О.Б., Соломяный В.В., Филимонов А.В., 20262026Белкин Е.В., Тулин П.Е., Бадеян А.М., Абу‑Хайдар О.Б., Соломяный В.В., Филимонов А.В.Belkin E.V., Tulin P.E., Badeyan A.M., Abu‑Khaidar O.B., Solomyanyy V.V., Filimonov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/508

Цель: Определить диагностическую эффективность ПЭТ/КТ с 68Ga-FAPI в М-стадировании рака желудка. Материалы и методы: В исследование включены 57 пациентов с верифицированным раком желудка. Всем пациентам проведены ПЭТ/КТ с 68Ga-FAPI и ПЭТ/КТ с 18F-FDG. Сравнивалась диагностическая точность ПЭТ/КТ с обоими РФЛП по параметрам чувствительности и специфичности в отношении выявления отдаленного метастатического поражения. Оценка данных проводилась на основании гистологически верифицированного заболевания и данных клинического наблюдения / дообследования. Результаты: 57 пациентов прошли ПЭТ/КТ с 68Ga-FAPI и ПЭТ/КТ с 18F-FDG. У 5 пациентов (8.7 %) схема лечения была изменена с радикального на паллиативное на основании результатов ПЭТ/КТ с 68Ga-FAPI. ПЭТ/КТ с 68Ga-FAPI выявила отдалённые метастазы у 29 пациентов (50.8 %), при использовании ¹⁸F-FDG отдаленные метастазы обнаружены у 18 пациентов (31.5 %). Чувствительность ПЭТ/КТ с 68Ga-FAPI в выявлении отдалённых метастазов составила 100 %, а специфичность — 85,7 %, тогда как для ¹⁸F-FDG эти показатели составили 62 % и 90 % соответственно. Заключение: ПЭТ/КТ с 68Ga-FAPI является более эффективным методом диагностики в выявлении отдаленных метастазов рака желудка, чем ПЭТ/КТ с 18F-FDG. Полученные результаты свидетельствуют о необходимости использования ПЭТ/КТ с 68Ga-FAPI в клинической практике для более точной диагностики и выбора тактики лечения при раке желудка.

Purpose: To determine the diagnostic effectiveness of PET/CT with 68Ga-FAPI in the detection and staging of metastases in patients with gastric cancer. Material and methods: The study included 57 patients with histologically confirmed gastric cancer. All patients underwent PET/CT with 68Ga-FAPI and PET/CT with 18F-FDG. The diagnostic accuracy of the methods was compared based on sensitivity and specificity parameters in detecting distant metastatic lesions. Data assessment was conducted based on histologically verified disease and clinical follow-up data. Results: 57 patients underwent both 68Ga-FAPI PET/CT and 18F-FDG PET/CT. In 5 patients (8.7 %), the treatment plan was changed from radical to palliative based on the 68Ga-FAPI PET/CT results. 68Ga-FAPI PET/CT detected distant metastases in 29 patients (50.8 %), while with 18F-FDG, distant metastases were detected in 18 patients (31.5 %). The sensitivity of 68Ga-FAPI PET/CT in detecting distant metastases was 100 %, with a specificity of 85.7 %, whereas for 18F-FDG, these values were 62 % and 90 %, respectively. Conclusion: PET/CT with 68Ga-FAPI is a more effective diagnostic method for detecting distant metastases of gastric cancer than PET/ CT with 18F-FDG. The obtained results indicate the need to use PET/CT with 68Ga-FAPI in clinical practice for more accurate diagnosis and treatment strategy selection in gastric cancer.

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The authors declare that there are no conflicts of interest present.