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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ojrdrt</journal-id><journal-title-group><journal-title xml:lang="ru">Онкологический журнал: лучевая диагностика, лучевая терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of oncology: diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7593</issn><issn pub-type="epub">2713-167X</issn><publisher><publisher-name>НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37174/2587-7593-2025-8-3-35-44</article-id><article-id custom-type="elpub" pub-id-type="custom">ojrdrt-464</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛУЧЕВАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RADIOTHERAPY</subject></subj-group></article-categories><title-group><article-title>Роль и место лучевой терапии в комплексном лечении больных первично-диссеминированным раком молочной железы. Обзор литературы и клинические наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Role and Place of Radiation Therapy in Complex Treatment of Patients with de novo Metastatic Breast Cancer. Literature Review and Clinical Observations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0504-1488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимошкина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Timoshkina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тимошкина Екатерина Валерьевна, +79104040067 </p><p>115478 Москва, Каширское шоссе, 24 </p></bio><bio xml:lang="en"><p>Ekaterina V. Timoshkina, +79104040067 </p><p>24 Kashirskoe highway, Moscow 115478 </p></bio><email xlink:type="simple">doctoretim@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7204-370X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимова</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimova</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24 </p><p>125993 Москва, ул. Баррикадная, д. 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>24 Kashirskoe highway, Moscow 115478 </p><p>2/1 b1, Barrikadnaya str., Moscow 125993</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8062-570X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глебовская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glebovskaya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>111123 Москва, ш. Энтузиастов, 86</p></bio><bio xml:lang="en"><p>86 Enthusiasts sh., Moscow 111123</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4944-4035</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черных</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernykh</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>24 Kashirskoe highway, Moscow 115478 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8965-8172</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачев</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachev</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24 </p></bio><bio xml:lang="en"><p>24 Kashirskoe highway, Moscow 115478 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1958-7262</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24 </p></bio><bio xml:lang="en"><p>24 Kashirskoe highway, Moscow 115478 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin National Medical Research Center of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава России ;  Российская медицинская академия непрерывного профессионального образования Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin National Medical Research Center of Oncology ; Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Московский клинический научный центр имени А.С. Логинова ДЗМ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.S. Loginov Moscow Clinical Scientific Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2025</year></pub-date><volume>8</volume><issue>3</issue><fpage>35</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тимошкина Е.В., Трофимова О.П., Глебовская В.В., Черных М.В., Ткачев С.И., Иванов С.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Тимошкина Е.В., Трофимова О.П., Глебовская В.В., Черных М.В., Ткачев С.И., Иванов С.М.</copyright-holder><copyright-holder xml:lang="en">Timoshkina E.V., Trofimova O.P., Glebovskaya V.V., Chernykh M.V., Tkachev S.I., Ivanov S.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.oncoradjournal.ru/jour/article/view/464">https://www.oncoradjournal.ru/jour/article/view/464</self-uri><abstract><p>Согласно актуальным клиническим рекомендациям ведущим методом лечения при первично-диссеминированном раке молочной железы (ПДРМЖ) является лекарственная терапия. Однако в настоящее время активно изучается возможность и целесообразность проведения локальных методов лечения первичного очага у вышеуказанных пациенток, таких как хирургическое вмешательство и лучевая терапия. В статье представлен обзор данных современной литературы, связанных с вопросами проведения дистанционной лучевой терапии у больных ПДРМЖ, и собственные клинические наблюдения.</p></abstract><trans-abstract xml:lang="en"><p>According to state-of-art clinical guidelines, the leading method of treatment for de novo metastatic breast cancer is systemic therapy. However, the possibility and feasibility of performing local methods in treating the primary lesion in the above mentioned patients, such as surgery and radiation therapy, is currently being actively studied. This article provides a review of modern literature data related to the issues of external beam radiation therapy in patients with de novo metastatic breast cancer and presents our own clinical observations.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первично-диссеминированный рак молочной железы</kwd><kwd>лучевая терапия</kwd><kwd>радикальный курс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>de novo primary breast cancer</kwd><kwd>radiotherapy</kwd><kwd>radical course</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации по лечению рака молочной железы, 2021 г.</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines for breast cancer treatment. 2021</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Breast cancer. 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