References

ojrdrt

Онкологический журнал: лучевая диагностика, лучевая терапия

Journal of oncology: diagnostic radiology and radiotherapy

2587-75932713-167X

НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»

10.37174/2587-7593-2025-8-2-32-41

ojrdrt-436

Research Article

ЯДЕРНАЯ МЕДИЦИНА

NUCLEAR MEDICINE

Петид-рецепторная радионуклидная терапия радиофармацевтическим лекарственным препаратом 177Lu-DOTA-TATE.

The peptide-receptor radinuclide therapy with radiopharmaceutical 177Lu-DOTA-TATE.

https://orcid.org/0000-0003-4934-2012

Шуринов

А. Ю.

Shurinov

A. Yu.

Шуринов Андрей Юрьевич

249031 Калужская обл., Обнинск, ул. Королева 4

Andrey Yu. Shurinov

shurinov@mrrc.obninsk.ru

https://orcid.org/0000-0001-6655-5592

Крылов

В. В.

Krylov

V. V.

249031 Калужская обл., Обнинск, ул. Королева 4

https://orcid.org/0000-0002-3306-5906

Бородавина

Е. В.

Borodavina

E. V.

249031 Калужская обл., Обнинск, ул. Королева 4

https://orcid.org/0000-0002-9426-8459

Северская

Н. В.

Severskaya

N. V.

249031 Калужская обл., Обнинск, ул. Королева 4

Медицинский радиологический научный центр им. А.Ф. Цыба, филиал ФГБУ НМИЦ радиологии Минздрава РоссииРоссияA.F. Tsyb Medical Radiological Research CenterRussian Federation

2025

29062025

823241

2025

Шуринов А.Ю., Крылов В.В., Бородавина Е.В., Северская Н.В.

Shurinov A.Y., Krylov V.V., Borodavina E.V., Severskaya N.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.oncoradjournal.ru/jour/article/view/436

Введение: Пептид-рецепторная радионуклидная терапия (ПРРТ) меченными 177Lu аналогами соматостатина давно стала признанным вариантом лечения во второй или третьей линии терапии пациентов с прогрессирующими дифференцированными (G1–2 степени) гастро-энтеро-панкреатическими нейроэндокринными опухолями (ГЭП-НЭО). На основании результатов исследования NETTER-II ПРРТ активно внедряется в качестве первой линии терапии гастроэнртеропанкретатическими нейроэндокринными опухолями (ГЭП-НЭО), в качестве неоадьювантного метода лечения. Цель: Анализ эффективности и безопасности метода пептид-рецепторной радионуклидной терапии 177Lu-DOTA-TATЕ по данным мировой литературы. Материалы и методы: Поиск литературных источников выполнялся в период с 01.06.2024 по 12.12.2024 в базах данных: Pubmed, Google Scholar, ELibrary по поисковым запросам: 177Lu-DOTA-TATE, 177Lu and NET, peptid-receptor radionuclide therapy. Результаты: 177Lu-DOTA-TATE является приоритетным РФЛП для радиотаргетной терапии больных метастатическими и неоперабельными нейроэндокринными опухолями (НЭО), и нейроэндокринными карциномами (НЭК) экспрессирующими соматостатиновые рецепторы 2-го типа (ССТР2) [1]. Рост заболеваемости на фоне улучшения диагностики НЭО, интенсивное развитие технологий ядерной медицины, в особенности методов радиотаргетной терапии, стали причиной повышенной заинтересованности в регистрации и широкомасштабном применении 177Lu-DOTA-TATE [2]. Обсуждение: 177Lu-DOTA-TATE был одобрен профильными зарубежными медицинскими организациями-регуляторами: Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA, USA) и Европейского медицинского агентства (EMA) [3, 4]. Анализ эффективности ПРРТ и нежелательных явлений характеризует данный вид радионуклидной терапии как безопасный и высокоэффективный. Заключение: Лечение пациентов с НЭО и НЭК, включающее ПРРТ, требует широкого набора специальных клинических знаний, что обусловливает необходимость обсуждения пациентов в экспертной мультидисциплинарной команде клиницистов (онкологи, эндокринологи, химиотерапевты, радиологи, радиотерапевты, патоморфологи и другие специалисты)

Introduction: Since 2016, peptide-receptor radionuclide therapy (PRRT) with 177Lu-labeled somatostatin analogues has become a recognized treatment option in the second or third line of patients with progressive differentiated (grade G1–2) gastroentero pancreatic neuroendocrine tumors (GEP-NET) with radiopharmaceutical 177Lu-DOTA-TATE. Based on the results of the NETTER-II study, PRRT is being actively introduced as a first-line therapy for GEP-NETs, as a neoadjuvant treatment. Purpose: Analysis of the effectiveness and safety of the peptide-receptor radionuclide therapy method 177Lu-DOTA-TATE, according to world literature. Materials and methods: The search for literary sources was carried out in the period from 01.06.2024 to 12.12.2024 in the databases: Pubmed, Google Scholar, ELibrary using the search queries: 177Lu-DOTA-TATE, 177Lu and NET, peptid-receptor radionuclide therapy. Results: This method of radiotargeting therapy used to treat patients with metastatic and inoperable neuroendocrine tumors (NET) and neuroendocrine carcinomas (NEC) expressing type 2 somatostatin receptors (SSTR2) [1]. The increase in the incidence and prevalence of NET in recent decades [2], and the development of specific treatment methods and protocols, there is a growing use of this type of radiotargeted therapy 177Lu-DOTA-TATE. Discussion: 177Lu-DOTA-TATE approved by relevant foreign medical regulatory organizations: FDA, EMA [3, 4]. Analysis of the PRRT method, treatment results, and side effects characterizes this method of radionuclide therapy as safe and highly effective. Conclusion: The treatment of patients with NETs and NECs, including PRRT, requires a wide range of specialized clinical knowledge, which necessitates discussing patients in an expert multidisciplinary team of clinicians (oncologists, endocrinologists, chemotherapists, radiologists, radiotherapists, pathologists and other specialists).

нейроэндокринные опухолисоматостатиновые рецепторыпептид-рецепторная радионуклидная терапиярадиофармацевтические лекарственные препараты177Lu-DOTA-TATE

neuroendocrine tumorssomatostatin receptorspeptide receptor radionuclide therapyradiopharmaceuticals177Lu-DOTA-TATE

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The authors declare that there are no conflicts of interest present.