<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ojrdrt</journal-id><journal-title-group><journal-title xml:lang="ru">Онкологический журнал: лучевая диагностика, лучевая терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of oncology: diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7593</issn><issn pub-type="epub">2713-167X</issn><publisher><publisher-name>НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37174/2587-7593-2024-7-4-62-67</article-id><article-id custom-type="elpub" pub-id-type="custom">ojrdrt-402</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛУЧЕВАЯ ДИАГНОСТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIAGNOSTIC RADIOLOGY</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности ультразвукового исследования в дифференциальной диагностике пациентов с неспецифическими воспалительными заболеваниями кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Ultrasound in the Management of Patients with Nonspecific Inflammatory Bowel Disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4543-9186</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дурлештер</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Durleshter</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Дурлештер Марина Владимировна</p><p>+7(988) 888-52-22 </p><p>Россия, 350012 Краснодар, ул. Красных Партизан, 6/2</p></bio><bio xml:lang="en"><p>Marina Vladimirovna Durleshter </p><p>6/2, Krasnykh Partizan str., Krasnodar 350012, Russia </p></bio><email xlink:type="simple">durleshter88@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2885-7674</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дурлештер</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Durleshter</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 350012 Краснодар, ул. Красных Партизан, 6/2</p><p>Россия, 350063, Краснодар, ул. Седина, 4 </p></bio><bio xml:lang="en"><p>6/2, Krasnykh Partizan str., Krasnodar 350012, Russia </p><p> 4, Sedina str., Krasnodar 350063 Russia </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1508-203X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катрич</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Katrich</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 350086 Краснодар, ул. 1 Мая, 167</p><p>Россия, 350063, Краснодар, Седина, 4 </p></bio><bio xml:lang="en"><p>167, 1st Maya str., Krasnodar 350086, Russia</p><p>4, Sedina str., Krasnodar 350063 Russia </p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Краевая клиническая больница № 2 МЗ Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital No. 2 Krasnodar Krai Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Краевая клиническая больница № 2 МЗ Краснодарского края;&#13;
Кубанский государственный медицинский  университет Минздрава России, кафедра хирургии №3 факультет повышения квалификации и профессиональной переподготовки специалистов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital No.2 Krasnodar Krai Ministry of Health;&#13;
Kuban State Medical University, Department of Surgery №3 Faculty of Advanced Training and Professional Retraining of Specialists</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Научно-исследовательский институт — Краевая  клиническая больница №1 им. проф. С.В.  Очаповского;&#13;
Кубанский государственный медицинский  университет Минздрава России, кафедра лучевой  диагностики №1 факультет повышения квалификации и профессиональной переподготовки  специалистов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute — S.V. Ochapovsky Regional Hospital №1; &#13;
Kuban State Medical University, Department of Surgery №1 Faculty of Advanced Training and Professional Retraining of Specialists</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>26</day><month>12</month><year>2024</year></pub-date><volume>7</volume><issue>4</issue><fpage>62</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дурлештер М.В., Дурлештер В.М., Катрич А.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Дурлештер М.В., Дурлештер В.М., Катрич А.Н.</copyright-holder><copyright-holder xml:lang="en">Durleshter M.V., Durleshter V.M., Katrich A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.oncoradjournal.ru/jour/article/view/402">https://www.oncoradjournal.ru/jour/article/view/402</self-uri><abstract><p>Актуальность: Болезнь Крона (БК) и язвенный колит (˔К) входят в группу воспалительных заболеваний кишечника (ВЗК) и относятся к группе потенциально инвалидизирующих болезней, имеющих до конца неизученную этиологию.Цель исследования: Определить наиболее значимые дифференциально-диагностические ультразвуковые признаки болезни Крона и язвенного колита.Материал и методы: На основании морфологических данных произведен анализ результатов диагностики и лечения 142 больных. По нозологической форме и стадии заболевания пациенты были разделены на 3 группы и несколько подгрупп: 1 группа (n = 84) — пациенты с ˔К; 2 группа (n = 58) — пациенты с БК; 3 группа (контрольная) (n = 27) — соматически здоровые добровольцы. Основным методом лучевой диагностики было ультразвуковое исследование (УЗИ).Результаты: При первичной диагностике наиболее информативными ультразвуковыми признаками ВЗК являются: утолщение и снижение эхогенности стенки толстой кишки, потеря гаустрации толстой кишки, повышение эхогенности параколической клетчатки, множественные локусы кровотока в стенке толстой кишки при цветовом доплеровском картировании (ЦДК) — чувствительность признаков у больных с ˔К составила 94,5 %, специфичность 97 %, при БК — 94 % и 97 й соответственно, (р &lt; 0,001). Выделены наиболее значимые дифференциально-диагностические ультразвуковые критерии при БК: локальное утолщение стенки толстой кишки более 10 мм, просвет кишки сужен менее чем на 3 мм, регионарные лимфатические узлы более 10 мм; и язвенного колита: локальное утолщение стенки толстой кишки с 3 до 10 мм, просвет кишки расширен (более 15 мм), регионарные лимфатические узлы от 8 до 10 мм (р &lt; 0,001). При проведении ROC-анализа пороговое значение критерия ͨтолщина стенкиͩ в дифференциальной диагностике БК и ЯК, при максимальной специфичности теста составило 10,5 мм (чувствительность 97 %, специфичность — 100 %); ͨдиаметр просветаͩ — 13 мм (чувствительность 80,6 %, специфичность — 97 %) соответственно.Выводы: Полученные результаты позволяют рекомендовать трансабдоминальное УЗИ кишечника как метод выбора для своевременной неинвазивной диагностики больных с наиболее распространенными формами ВЗК.</p></abstract><trans-abstract xml:lang="en"><p>Introduction: Crohn’s disease (CD) and ulcerative colitis (UC) are included in the group of inflammatory bowel diseases (IBD) and belong to the group of potentially disabling diseases with an unknown etiology.Study objective: Determine the most significant differential diagnostic ultrasound signs of Crohn’s disease and ulcerative colitis.Material and methods: Based on morphological data, the analysis of diagnostic and treatment results of 142 patients was performed. According to the nosological form and stage of the disease, the patients were divided into 3 groups and several subgroups: Group 1 (n = 84) — patients with UC; Group 2 (n = 58) — patients with CD; Group 3 (control) (n = 27) — somatically healthy volunteers. The main method of radiation diagnostics was ultrasound.Results: In primary diagnostics, the most informative ultrasound signs of IBD are: thickening and decreased echogenicity of the colon wall, loss of colon haustration, increased echogenicity of paracolic tissue, multiple blood flow loci in the colon wall during CDC — the sensitivity of signs in patients with UC was 94.5 %, specificity 97 %, in CD 94 % and 97 %, respectively (p &lt; 0.001). The most significant differential diagnostic ultrasound criteria for CD are identified: local thickening of the colon wall by more than 10 mm, intestinal lumen narrowed by less than 3 mm, regional lymph nodes more than 10 mm; and ulcerative colitis — local thickening of the colon wall from 3 to 10 mm, dilated intestinal lumen (more than 15 mm), regional lymph nodes from 8 to 10 mm (p &lt; 0.001). When conducting ROC analysis, the threshold value of the “wall thickness” criterion in the differential diagnosis of CD and UC, with the maximum specificity of the test was 10.5 mm (sensitivity 97 %, specificity — 100 %); “lumen diameter”— 13 mm (sensitivity 80.6 %, specificity — 97 %), respectively.Conclusions: The obtained results allow us to recommend transabdominal ultrasound of the intestine as the method of choice for timely non-invasive diagnosis of patients with the most common forms of IBD.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>язвенный колит</kwd><kwd>неспецифические заболевания кишечника</kwd><kwd>дифференциальная диагностика</kwd><kwd>ультразвуковое исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn’s disease</kwd><kwd>ulcerative colitis</kwd><kwd>nonspecific intestinal diseases</kwd><kwd>differential diagnostic</kwd><kwd>ultrasound diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин ВТ, Шелыгин ЮА, Ачкасов СИ и др. Рекомендации Российской гастроэнтерологической Ассоциации колопроктологов России по диагностике и лечению взрослых больных дивертикулярной болезнью ободочной кишки. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016;26(1):65-80. https://doi.org/10.22416/1382-4376-2016-26-1-65-80</mixed-citation><mixed-citation xml:lang="en">Ivashkin VT, Shelygin YuA, Achkasov SI, et al. Recommendations of the Russian Gastroenterological Association of Proctologists of Russia for the diagnosis and treatment of adult patients with diverticular disease of the colon. Russian Journal of Gastroenterology, Hepatology, Proctology. 2016;26(1):65-80 (In Russ.) https://doi.org/10.22416/1382-4376-2016-26-1-65-80</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Oka A, Sartor RB. Microbial-Based and Microbial-Targeted Therapies for InŇammatory Bowel Diseases. Dig Dis Sci. 2020;65(3):757-88. PMID: 32006212 https://doi.org/10.1007/s10620-020-06090-z.</mixed-citation><mixed-citation xml:lang="en">Oka A, Sartor RB. Microbial-Based and Microbial-Targeted Therapies for InŇammatory Bowel Diseases. Dig Dis Sci. 2020;65(3):757-88. PMID: 32006212 https://doi.org/10.1007/s10620-020-06090-z.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan GG, Ng SC. Globalisation of inŇammatory bowel disease: perspectives from the evolution of inŇammatory bowel disease in the UK and China. Lancet Gastroenterol. 2016;1(4):307-16. PMID: 28404201. https://doi.org/10.1016/S2468-1253(16)30077-2.</mixed-citation><mixed-citation xml:lang="en">Kaplan GG, Ng SC. Globalisation of inŇammatory bowel disease: perspectives from the evolution of inŇammatory bowel disease in the UK and China. Lancet Gastroenterol. 2016;1(4):307-16. PMID: 28404201. https://doi.org/10.1016/S2468-1253(16)30077-2.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Peery AF, Crocket SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology. 2018;156(1):254-72. https://doi:10.1053/j.gastro.2018.08.063. PMID: 30315778.</mixed-citation><mixed-citation xml:lang="en">Peery AF, Crocket SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology. 2018;156(1):254-72. https://doi:10.1053/j.gastro.2018.08.063. PMID: 30315778.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Le Berre C, Ananthakrishnan AN, Danese S. Ulcerative Colitis and Crohn’s Disease Have Similar Burden and Goals for Treatment. Clin Gastroenterol Hepatol. 2020;18(1):14-23. https://doi.org/10.1016/j.cgh.2019.07.005. PMID: 30315778.</mixed-citation><mixed-citation xml:lang="en">Le Berre C, Ananthakrishnan AN, Danese S. Ulcerative Colitis and Crohn’s Disease Have Similar Burden and Goals for Treatment. Clin Gastroenterol Hepatol. 2020;18(1):14-23. https://doi.org/10.1016/j.cgh.2019.07.005. PMID: 30315778.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Головенко ОВ. Современные принципы консервативного лечения легкой и среднетяжелой форм язвенного колита. Лечащий врач. 2022;25(11):82-9. https://doi.org/10.51793/os.2022.25.11.014</mixed-citation><mixed-citation xml:lang="en">Golovenko OV. Modern principles of conservative treatment of mild and moderate forms of ulcerative colitis. Attending Physician. 2022;25(11):82-9. (In Russ.) https://doi.org/10.51793/os.2022.25.11.014</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gomollſn F, Dignass A, Annese V, et al. ECCO. 3rd European Evidencebased Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management. J Crohn’s Colitis. 2017;11:3-25. https://doi:10.1093/ecco-jcc/jjw168. PMID: 27660341.</mixed-citation><mixed-citation xml:lang="en">Gomollſn F, Dignass A, Annese V, et al. ECCO. 3rd European Evidencebased Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management. J Crohn’s Colitis. 2017;11:3-25. https://doi:10.1093/ecco-jcc/jjw168. PMID: 27660341.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sturm A, Maaser C, Calabrese E, et al. European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR]. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects. J Crohn’s Colitis. 2019;13:273-84. https://doi.org/10.1093/ecco-jcc/jjy114.</mixed-citation><mixed-citation xml:lang="en">Sturm A, Maaser C, Calabrese E, et al. European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR]. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects. J Crohn’s Colitis. 2019;13:273-84. https://doi.org/10.1093/ecco-jcc/jjy114.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gajendran M, Loganathan P, Catinella AP, et al. A comprehensive review and update on Crohn’s disease. Dis Mon. 2017;64:20-57. PMID: 28826742. https://doi:10.1016/j.disamonth.2017.07.001.</mixed-citation><mixed-citation xml:lang="en">Gajendran M, Loganathan P, Catinella AP, et al. A comprehensive review and update on Crohn’s disease. Dis Mon. 2017;64:20-57. PMID: 28826742. https://doi:10.1016/j.disamonth.2017.07.001.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Castiglione F, Mainenti P, Testa A, et al. Crosssectional evaluation of transmural healing in patients with Crohn’s disease on maintenance treatment with anti-TNF alpha agents. Dig Liver Dis. 2017;49:484-89. https://doi.org/10.1016/j.dld.2017.02.014. PMID: 28292640.</mixed-citation><mixed-citation xml:lang="en">Castiglione F, Mainenti P, Testa A, et al. Crosssectional evaluation of transmural healing in patients with Crohn’s disease on maintenance treatment with anti-TNF alpha agents. Dig Liver Dis. 2017;49:484-89. https://doi.org/10.1016/j.dld.2017.02.014. PMID: 28292640.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes SR, Rodrigues RV, Bernardo S, et al Transmural healing is associated with improved long-term outcomes of patients with Crohn’s disease. InŇamm Bowel Dis. 2017;23:1403-9. PMID: 28498158. https://doi.org/10.1097/MIB.0000000000001143.</mixed-citation><mixed-citation xml:lang="en">Fernandes SR, Rodrigues RV, Bernardo S, et al Transmural healing is associated with improved long-term outcomes of patients with Crohn’s disease. InŇamm Bowel Dis. 2017;23:1403-9. PMID: 28498158. https://doi.org/10.1097/MIB.0000000000001143.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor SA, Mallett S, Bhatnagar G. METRIC study investigators. Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial. Lancet Gastroenterol Hepatol. 2018;3:548-58. https://doi.org/10.1016/S2468-1253(18)30161-4. PMID: 29914843.</mixed-citation><mixed-citation xml:lang="en">Taylor SA, Mallett S, Bhatnagar G. METRIC study investigators. Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial. Lancet Gastroenterol Hepatol. 2018;3:548-58. https://doi.org/10.1016/S2468-1253(18)30161-4. PMID: 29914843.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">De Voogd F, Wilkens R, Gecse K, et al. A reliability study: strong inter-observer agreement of an expert panel for intestinal ultrasound in ulcerative colitis. J Crohn’s Colitis. 2021;15:1284-90. https://doi.org/10.1093/ecco-jcc/jjaa267. PMID: 33420784.</mixed-citation><mixed-citation xml:lang="en">De Voogd F, Wilkens R, Gecse K, et al. A reliability study: strong inter-observer agreement of an expert panel for intestinal ultrasound in ulcerative colitis. J Crohn’s Colitis. 2021;15:1284-90. https://doi.org/10.1093/ecco-jcc/jjaa267. PMID: 33420784.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dolinger M, Verstockt B. Ulcerative colitis, a transmural disease requiring an accurate IUS assessment in the current treat-to-target era. United Eur Gastroenterol J. 2022;10(3):247-8. https://doi.org/10.1002/ueg2.12215. PMID: 35230746.</mixed-citation><mixed-citation xml:lang="en">Dolinger M, Verstockt B. Ulcerative colitis, a transmural disease requiring an accurate IUS assessment in the current treat-to-target era. United Eur Gastroenterol J. 2022;10(3):247-8. https://doi.org/10.1002/ueg2.12215. PMID: 35230746.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fufezan O, Asavoaie C, Tamas A, et al. Bowel elastography — a pilot study for developing an elastographic scoring system to evaluate disease activity in pediatric Crohn’s disease. Med Ultrason. 2015 Dec;17(4):422-30. https://doi.org/10.11152/mu.2013.2066.174.bwe. PMID: 26649334.</mixed-citation><mixed-citation xml:lang="en">Fufezan O, Asavoaie C, Tamas A, et al. Bowel elastography — a pilot study for developing an elastographic scoring system to evaluate disease activity in pediatric Crohn’s disease. Med Ultrason. 2015 Dec;17(4):422-30. https://doi.org/10.11152/mu.2013.2066.174.bwe. PMID: 26649334.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
