ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2024-7-4-28-39ojrdrt-397Research ArticleЛУЧЕВАЯ ТЕРАПИЯRADIOTHERAPYБор-нейтронозахватная терапия с борфенилаланином в экспериментальной онкологии и ветеринарной практикеBoron Neutron Capture Therapy with Boronophenylalanine in Experimental Oncology and Veterinary Practicehttps://orcid.org/0000-0002-5144-1039ФиногеноваЮ. А.FinogenovaYu. A.

Финогенова Юлия Андреевна

+7 915 418 9923 

Россия, 115478, Москва, Каширское шоссе, 24

Yulia A. Finogenova

+7 915 418 9923 

24 Kashirskoe Shosse, Moscow, Russia 115478 

b-f.finogenova@yandex.ruhttps://orcid.org/0000-0002-5631-9016ЛипенгольцА. А.LipengoltsA. A.

Россия, 115478, Москва, Каширское шоссе, 24

Россия, 119991, Москва, Ленинский проспект, 31 

24 Kashirskoe Shosse, Moscow, Russia 115478

31, Leninskii prospekt, Moscow, Russia, 119991 

https://orcid.org/0000-0003-0246-1794ШпаковаК. Е.ShpakovaK. E.

Россия, 115478, Москва, Каширское шоссе, 24

Россия, 119991, Москва, Ленинский проспект, 31 

24 Kashirskoe Shosse, Moscow, Russia 115478

31, Leninskii prospekt, Moscow, Russia, 119991 

https://orcid.org/0000-0003-2942-7895СкрибицкийВ. А.SkribitskyV. A.

Россия, 115478, Москва, Каширское шоссе, 24

Россия, 119991, Москва, Ленинский проспект, 31 

24 Kashirskoe Shosse, Moscow, Russia 115478

31, Leninskii prospekt, Moscow, Russia, 119991 

https://orcid.org/0000-0003-0386-9732СмирноваА. В.SmirnovaA. V.

Россия, 115478, Москва, Каширское шоссе, 24

Россия, 111123, Москва, ул. Новогиреевская, 1 

24 Kashirskoe Shosse, Moscow, Russia 115478 

86, Shosse Entuziastov, Moscow, Russia, 111123 

https://orcid.org/0000-0001-7726-7991ГригорьеваЕ. Ю.GrigorievaE. Yu.

Россия, 115478, Москва, Каширское шоссе, 24

 24 Kashirskoe Shosse, Moscow, Russia 115478 

Национальный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationНациональный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава России; Институт общей и неорганической химии им. Н.С. Курнакова РАНРоссияN.N. Blokhin National Medical Research Center of Oncology; N.S. Kurnakov Institute of General and Inorganic ChemistryRussian FederationНациональный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава России; Московский клинический научно-практический центр им. А.С. Логинова ДЗМРоссияN.N. Blokhin National Medical Research Center of Oncology; A.S. Loginov Moscow Clinical Scientific CenterRussian Federation202426122024742839Copyright © Финогенова Ю.А., Липенгольц А.А., Шпакова К.Е., Скрибицкий В.А., Смирнова А.В., Григорьева Е.Ю., 20242024Финогенова Ю.А., Липенгольц А.А., Шпакова К.Е., Скрибицкий В.А., Смирнова А.В., Григорьева Е.Ю.Finogenova Y.A., Lipengolts A.A., Shpakova K.E., Skribitsky V.A., Smirnova A.V., Grigorieva E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/397

Нейтронозахватная терапия (НЗТ) — высокоизбирательный метод бинарной лучевой терапии злокачественных новообразований, основанный на физическом явлении радиационного захвата тепловых нейтронов ядрами атомов. В настоящее время в клинической практике используется только вариант НЗТ с изотопом 10B, известный как бор-нейтронозахватная терапия (БНЗТ). Для доставки 10В в опухоль наиболее широко применяется борфенилаланин (БФА) — модифицированная аминокислота. Несмотря на уже более чем 70-летнюю историю клинического применения БНЗТ и многообещающие результаты лечения пациентов с опухолями различных нозологий, данная технология все еще находится на стадии развития и изучения. Наиболее актуальными вопросами являются изучение и прогнозирование лучевых реакций здоровых и опухолевых тканей при проведении БНЗТ с БФА. Ответы на эти вопросы можно получить лишь в исследованиях на животных. В обзоре представлены результаты исследований БНЗТ как на лабораторных животных с различными модельными опухолевыми патологиями, так и в ветеринарной практике. Рассмотрены индуцированные и перевивные модели опухолей центральной нервной системы, ротовой полости, а также подкожные и метастатические модели. Полученные результаты указывают на потенциальную высокую противоопухолевую эффективность БНЗТ с БФА и на принципиально иные механизмы воздействия БНЗТ на опухолевые и нормальные ткани по сравнению с другими известными методами лучевой терапии. Многие вопросы все еще требуют дополнительного изучения с использованием современных методов исследования, таких как прижизненная in vivo визуализация лабораторных животных.

Neutron Capture Therapy (NCT) — highly selective method of binary radiotherapy of malignancies, which is based on physical phenomenon of thermal neutron radiation capture by atoms’ nuclei. Currently only 10B mediated NCT, known as boron neutron capture therapy (BNCT), is used in clinical practice. Boronophenylalanine — a modified amino acid is most widely used as 10B carrier. Despite of more than 70-years history of BCNT clinical application and promising results of curing patients with different tumors, this method of treatment is still under research and development. The most urgent issue is studying and prediction of radiation effects of healthy and tumor tissues after BNCT application. This task can be solved in experiments involving animals. The review contains results of BNCT studies both in laboratory animals with different tumor models and veterinary practice. Induced and transplanted models of central nervous system, oral cavity as well as subcutaneous and metastatic models are considered in the review. Obtained results of the studies show possible high antitumor efficacy of BPA mediated BNCT and fundamentally different mechanisms of BNCT effect on tumor and healthy tissues comparing to other known types of radiotherapy. Many issues still require addition research with modern methods of studies, such as in vivo preclinical imaging.

БНЗТборфенилаланинветеринариязлокачественные опухолиопухолевые моделитерапевтическая эффективностьлучевые реакции тканейBNCTboronophenylalanineveterinarymalignant tumorstumor modelstherapeutic efficacytissues radiation effectsИсследование выполнено за счет гранта Российского Научного Фонда № 24-25-00446, https://rscf.ru/project/24-25-00446/The study was funded by Russian Science Foundation project № 24-25-00446, https://rscf.ru/project/24-25-00446/ReferencesLipengolts A, Finogenova Y, Skribitsky V, Grigorieva E. Binary technologies of malignant tumors radiotherapy. Journal of Physics Conference Series. 2021;2058(1):012039-012039. https://doi.org/10.1088/1742-6596/2058/1/012039Lipengolts A, Finogenova Y, Skribitsky V, Grigorieva E. Binary technologies of malignant tumors radiotherapy. Journal of Physics Conference Series. 2021;2058(1):012039-012039. https://doi.org/10.1088/1742-6596/2058/1/012039Липенгольц АА, Григорьева ЕЮ, Иванов СМ и др. 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The authors declare that there are no conflicts of interest present.