ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2024-7-4-19-27ojrdrt-396Research ArticleЛУЧЕВАЯ ТЕРАПИЯRADIOTHERAPYБор-нейтронозахватная терапия: физические аспектыBoron Neutron Capture Therapy: Physical Aspectshttps://orcid.org/0000-0003-3561-2990БикчуринаМ. И.BikchurinaM. I.

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

https://orcid.org/0000-0001-5649-524XКасатовД. А.KasatovD. A.

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

https://orcid.org/0000-0001-8522-0499КолесниковЯ. А.KolesnikovI. A.

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

https://orcid.org/0000-0002-4493-5612СоколоваЕ. О.SokolovaE. O.

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

https://orcid.org/0000-0002-2812-2574ТаскаеваЮ. С.TaskaevaI. S.

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

Россия, 630117 Новосибирск, ул. Арбузова, 6 

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

6, Arbuzova str., Novosibirsk, 630117, Russia 

https://orcid.org/0000-0002-5313-2563ТаскаевС. Ю.TaskaevS. Yu.

 Сергей Юрьевич Таскаев

+7 923 128 3601 

Россия, 630090 Новосибирск, пр. Лаврентьева, 11

Россия, 630090 Новосибирск, ул. Пирогова, 2 

 Sergey Yu. Taskaev

+7 923 128 3601

11, Lavrentiev ave., Novosibirsk, 630090, Russia

2, Pirogov str., Novosibirsk, 630090, Russia 

taskaev@inp.nsk.suИнститут ядерной физики им. Г.И. Будкера СО РАН; Новосибирский государственный университетРоссияG.I. Budker Institute of Nuclear Physics; Novosibirsk State UniversityRussian FederationИнститут ядерной физики им. Г.И. Будкера СО РАН; Новосибирский государственный университет; Научно-исследовательский институт клинической и экспериментальной лимфологииРоссияG.I. Budker Institute of Nuclear Physics; Novosibirsk State University; Research Institute of Clinical and Experimental LymphologyRussian Federation2024271220247419‑27Copyright © Бикчурина М.И., Касатов Д.А., Колесников Я.А., Соколова Е.О., Таскаева Ю.С., Таскаев С.Ю., 20242024Бикчурина М.И., Касатов Д.А., Колесников Я.А., Соколова Е.О., Таскаева Ю.С., Таскаев С.Ю.Bikchurina M.I., Kasatov D.A., Kolesnikov I.A., Sokolova E.O., Taskaeva I.S., Taskaev S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/396

Приведены основы бор-нейтронозахватной терапии злокачественных опухолей (БНЗТ), представлены требования к терапевтическому пучок нейтронов, перечислены источники нейтронов, используемые или разрабатываемые для БНЗТ, указаны особенности дозиметрии и системы планирования терапии. 

The basics of Boron Neutron Capture Therapy (BNCT) of malignant tumors and requirements for a therapeutic neutron beam are presented, neutron sources used or being developed for BNCT are listed, and features of dosimetry and  treatment planning system are indicated. 

бор-нейтронозахватная терапияисточник нейтроновускоритель заряженных частицнейтроногенерирующая мишеньboron neutron capture therapyneutron sourcecharged particle acceleratorneutron-generating targetИсследование выполнено за счет гранта Российского научного фонда № 19-72-30005, https://rscf.ru/project/19-72-30005/This work was supported by the Russian Science Foundation (grant number 19-72-30005), https://rscf.ru/project/19-72-30005/ReferencesNeutron Capture Therapy. Principles and Applications / Ed. by: W. Sauerwein, A. Wiƫg, R. Moss, Y. Nakagawa. — Springer. 2012. — 553 p.Neutron Capture Therapy. Principles and Applications / Ed. by: W. Sauerwein, A. Wiƫg, R. Moss, Y. Nakagawa. — Springer. 2012. — 553 p.Таскаев СЮ, Каныгин ВВ. Бор-нейтронозахватная терапия / Новосибирск: Издательство СО РАН. 2016. — 216 с.Taskaev S, Kanygin V. Boron neutron capture therapy / Novosibirsk. 2016. — 216 p. (In Russ.).Dymova M, Taskaev S, Richter V, Kuligina E. Boron neutron capture therapy: current status and future perspectives. Cancer Communications. 2020;40:406-21. https://doi.org/0.1002/cac2.12089.Dymova M, Taskaev S, Richter V, Kuligina E. Boron neutron capture therapy: current status and future perspectives. Cancer Communications. 2020;40:406-21. https://doi.org/0.1002/cac2.12089.Ahmed M, Alberti D, Altieri S, et al. Advances in Boron Neutron Capture Therapy. International Atomic Energy Agency, Vienna, Austria. 2023. 416 p.Ahmed M, Alberti D, Altieri S, et al. Advances in Boron Neutron Capture Therapy. International Atomic Energy Agency, Vienna, Austria. 2023. 416 p.Taskaeva I, Kasatova A, Surodin D, Bgatova N, Taskaev S. Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing of Lithium Neutron Capture Therapy. Life. 2013;13:518. https://doi.org/10.3390/life13020518.Taskaeva I, Kasatova A, Surodin D, Bgatova N, Taskaev S. Study of Lithium Biodistribution and Nephrotoxicity in Skin Melanoma Mice Model: The First Step towards Implementing of Lithium Neutron Capture Therapy. Life. 2013;13:518. https://doi.org/10.3390/life13020518.Макаров АН, Таскаев СЮ. Пучок моноэнергетических нейтронов для калибровки детектора темной материи. Письма в журнал технической физики. 2013;97(12):769-71. https://doi.org/10.1134/S0021364013120072.Makarov AN, Taskaev SYu. Beam of Monoenergetic Neutrons for the Calibration of a Dark-Matter Detector. JETP Letters. 2013;97(12):667-9. (In Russ.). https://doi.org/10.1134/S0021364013120072.Vendera A, Praena J. Study on novel neutron irradiation without beam shaping assembly in Boron Neutron Capture Therapy. Sci Rep. 2024;14:22434. https://doi.org/10.1038/s41598-024-73458-w.Vendera A, Praena J. Study on novel neutron irradiation without beam shaping assembly in Boron Neutron Capture Therapy. Sci Rep. 2024;14:22434. https://doi.org/10.1038/s41598-024-73458-w.Lacoste V. Review of radiation sources, calibration facilities and simulated workplace fields. Radiat Measur. 2010;45:1083-89. https://doi.org/10.1016/j.radmeas.2010.05.036.Lacoste V. Review of radiation sources, calibration facilities and simulated workplace fields. Radiat Measur. 2010;45:1083-89. https://doi.org/10.1016/j.radmeas.2010.05.036.Lee CL, Zhou y-L. Thick target neutron yields for the 7Li(p,n)7Be reaction near threshold. Nucl Instrum Meth Phys Res B. 1999;152(1):1-11. https://doi.org/10.1016/S0168-583y(99)00026-9.Lee CL, Zhou y-L. Thick target neutron yields for the 7Li(p,n)7Be reaction near threshold. Nucl Instrum Meth Phys Res B. 1999;152(1):1-11. https://doi.org/10.1016/S0168-583y(99)00026-9.Taskaev S, Berendeev E, Bikchurina M, et al. Neutron Source Based on Vacuum Insulated Tandem Accelerator and Lithium Target. Biology. 2021;10:350. https://doi.org/10.3390/biology10050350.Taskaev S, Berendeev E, Bikchurina M, et al. Neutron Source Based on Vacuum Insulated Tandem Accelerator and Lithium Target. Biology. 2021;10:350. https://doi.org/10.3390/biology10050350.Таскаев СЮ. Ускорительный источник нейтронов VITA. М.: ФИЗМАТЛИТ. 2024. — 248 c. Taskaev S. Accelerator based neutron source VITA. M.: FIZMATLIT. 2024. — 248 p. (In Russ.).Taskaev S. Accelerator based neutron source VITA. M.: FIZMATLIT. 2024. — 248 p. (In Russ.).Zaboronok A, Byvaltsev V, Kanygin V, et al. Boron-neutron capture therapy in Russia: preclinical evaluation of efficacy and perspectives of its application in neurooncology. New Armenian Medical Journal. 2017;11(1):6-15.Zaboronok A, Byvaltsev V, Kanygin V, et al. Boron-neutron capture therapy in Russia: preclinical evaluation of efficacy and perspectives of its application in neurooncology. New Armenian Medical Journal. 2017;11(1):6-15.Sato E, Zaboronok A, Yamamoto T, et al. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. J Radiat Res. 2018;59(2):101-7. https://doi.org/10.1093/jrr/rrx071.Sato E, Zaboronok A, Yamamoto T, et al. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. J Radiat Res. 2018;59(2):101-7. https://doi.org/10.1093/jrr/rrx071.Каныгин В, Касатова А, Разумов И и др. Оценка эффективности воздействия бор-нейтронозахватной терапии на различные опухолевые и нормальную клеточные культуры. Сибирский онкологический журнал. 2021;20(3):56-66. https://doi.org/10.21294/1814-4861-2021-20-3-56-66.Kanygin V, Kasatova A, Razumov I, et al. Assessment of the effect of boron neutron capture therapy on tumor cell lines and primary embryonic cell culture. Siberian Journal of Oncology. 2021;20(3):56-66. (In Russ.). https://doi.org/10.21294/1814-4861-2021-20-3-56-66.Каныгин В, Касатова А, Завьялов Е и др. Эффекты бор-нейтронозахватной терапии на рост подкожных ксенографтов колоректальной аденокарциномы человека SW-620 у иммунодефицитных мышей. Бюллетень экспериментальной биологии и медицины. 2021;172(9):356-61. https://doi.org/10.1007/s10517-022-05392-8.Kanygin V, Kasatova A, Zavjalov E, et al. Effects of boron neutron capture therapy on the growth of subcutaneous xenografts of human colorectal adenocarcinoma SW-620 in immunodeficient mice. Bulletin of Experimental Biology and Medicine. 2021;172(9):356-61. (In Russ.). https://doi.org/10.1007/s10517-022-05392-8.Kanygin V, Kichigin A, Zaboronok A, et al. in vivo Accelerator-based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series. Biology. 2022;11:138. https://doi.org/10.3390/biology11010138.Kanygin V, Kichigin A, Zaboronok A, et al. in vivo Accelerator-based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series. Biology. 2022;11:138. https://doi.org/10.3390/biology11010138.Kanygin V, Zaboronok A, Kichigin A, et al. Gadolinium neutron capture therapy for cats and dogs with spontaneous tumors using Gd-DTPA. Veterinary Sciences. 2023;10:274. https://doi.org/10.3390/vetsci10040274.Kanygin V, Zaboronok A, Kichigin A, et al. Gadolinium neutron capture therapy for cats and dogs with spontaneous tumors using Gd-DTPA. Veterinary Sciences. 2023;10:274. https://doi.org/10.3390/vetsci10040274.Dymova M, Dmitrieva M, Kuligina E, et al. Method of measuring high-LET particles dose. Radiat Res. 2021;196:192-6. https://doi.org/10.1667/RADE-21-00015.1.Dymova M, Dmitrieva M, Kuligina E, et al. Method of measuring high-LET particles dose. Radiat Res. 2021;196:192-6. https://doi.org/10.1667/RADE-21-00015.1.Bykov T, Kasatov D, Koshkarev A, et al. Initial trials of a dose monitoring detector for boron neutron capture therapy. J Instrum. 2021;16:P01024. https://doi.org/10.1088/1748-0221/16/01/P01024.Bykov T, Kasatov D, Koshkarev A, et al. Initial trials of a dose monitoring detector for boron neutron capture therapy. J Instrum. 2021;16:P01024. https://doi.org/10.1088/1748-0221/16/01/P01024.Bykov T, Kasatov D, Koshkarev A, et al. Evaluation of depthdose profiles in a water phantom at the BNCT facility at BINP. J Instrum. 2021;16:P10016. https://doi.org/10.1088/1748-0221/16/10/P10016.Bykov T, Kasatov D, Koshkarev A, et al. Evaluation of depthdose profiles in a water phantom at the BNCT facility at BINP. J Instrum. 2021;16:P10016. https://doi.org/10.1088/1748-0221/16/10/P10016.Byambatseren E, Burdakov A, Bykov T, et al. Validation and optimization of the epithermal neutron Ňux detector using the 71Ga(n,ɶ)72Ga reaction. J Instrum. 2023;18:P02020. https://doi.org/10.1088/1748-0221/18/02/P02020.Byambatseren E, Burdakov A, Bykov T, et al. Validation and optimization of the epithermal neutron Ňux detector using the 71Ga(n,ɶ)72Ga reaction. J Instrum. 2023;18:P02020. https://doi.org/10.1088/1748-0221/18/02/P02020.Sycheva T, Berendeev E, Verkhovod G, Taskaev S. A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy. Appl Radiat Isotopes. 2023;198:110818. https://doi.org/10.1016/j.apradiso.2023.110818.Sycheva T, Berendeev E, Verkhovod G, Taskaev S. A single coned Poly-Biz moderator designed for animal irradiation in boron neutron capture therapy. Appl Radiat Isotopes. 2023;198:110818. https://doi.org/10.1016/j.apradiso.2023.110818.Bikchurina M, Bykov T, Ibrahim I, et al. Dosimetry for Boron Neutron Capture Therapy Developed and Verified at the Accelerator based Neutron Source VITA. Frontiers in Nuclear Engineering. 2023;2:1266562. https://doi.org/10.3389/fnuen.2023.1266562.Bikchurina M, Bykov T, Ibrahim I, et al. Dosimetry for Boron Neutron Capture Therapy Developed and Verified at the Accelerator based Neutron Source VITA. Frontiers in Nuclear Engineering. 2023;2:1266562. https://doi.org/10.3389/fnuen.2023.1266562.Успенский СА, Хаптаханова ПА, Заборонок АА и др. Получение наночастиц элементного бора методом ультразвуковой обработки в водной среде и их применение в бор-нейтронозахватной терапии. Доклады Российской академии наук. Химия, науки о материалах. 2020;491:1-5. https://doi.org/10.1134/S0012500820030027.Uspenskii S, Khaptakhanova P, Zaboronok A, et al. Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. Doklady Chemistry. 2020;491(1);45-8. (In Russ.). https://doi.org/10.1134/S0012500820030027.Zavjalov E, Zaboronok A, Kanygin V, et al. Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice. Int J Radiat Biol. 2020;96(7):868-78. https://doi.org/10.1080/09553002.2020.1761039.Zavjalov E, Zaboronok A, Kanygin V, et al. Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice. Int J Radiat Biol. 2020;96(7):868-78. https://doi.org/10.1080/09553002.2020.1761039.Vorobyeva M, Dymova M, Novopashina D, et al. Tumor Cell-Specific 2’-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as a Potential Agent for Boron Neutron Capture Therapy. Int J Molec Sci. 2021;22:7326. https://doi.org/10.3390/ijms22147326.Vorobyeva M, Dymova M, Novopashina D, et al. Tumor Cell-Specific 2’-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as a Potential Agent for Boron Neutron Capture Therapy. Int J Molec Sci. 2021;22:7326. https://doi.org/10.3390/ijms22147326.Zaboronok A, Taskaev S, Volkova O, et al. Gold Nanoparticles Permit in Situ Absorbed Dose Evaluation in Boron Neutron Capture Therapy for Malignant Tumors. Pharmaceutics. 2021;13:1490. https://doi.org/10.3390/pharmaceutics13091490.Zaboronok A, Taskaev S, Volkova O, et al. Gold Nanoparticles Permit in Situ Absorbed Dose Evaluation in Boron Neutron Capture Therapy for Malignant Tumors. Pharmaceutics. 2021;13:1490. https://doi.org/10.3390/pharmaceutics13091490.Popova T, Dymova M, Koroleva L, et al. Homocystamide conjugates of human serum albumin as a plaƞorm to prepare bimodal multidrug delivery systems for boron-neutron capture therapy. Molecules. 2021;26:6537. https://doi.org/37.10.3390/molecules26216537.Popova T, Dymova M, Koroleva L, et al. Homocystamide conjugates of human serum albumin as a plaƞorm to prepare bimodal multidrug delivery systems for boron-neutron capture therapy. Molecules. 2021;26:6537. https://doi.org/37.10.3390/molecules26216537.Kanygin V, Razumov I, Zaboronok A, et al. Dose-dependent suppression of human glioblastoma xenograft growth by accelerator-based boron neutron capture therapy with simultaneous use of two boron-containing compounds. Biology. 2021;10:1124. https://doi.org/10.3390/biology10111124.Kanygin V, Razumov I, Zaboronok A, et al. Dose-dependent suppression of human glioblastoma xenograft growth by accelerator-based boron neutron capture therapy with simultaneous use of two boron-containing compounds. Biology. 2021;10:1124. https://doi.org/10.3390/biology10111124.Zaboronok A, Khaptakhanova P, Uspenskii S, et al. Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments. Pharmaceutics. 2022;14:761. https://doi.org/10.3390/pharmaceutics14040761.Zaboronok A, Khaptakhanova P, Uspenskii S, et al. Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments. Pharmaceutics. 2022;14:761. https://doi.org/10.3390/pharmaceutics14040761.Aiyyzhy K, Barmina E, Zavestovskaya I, et al. Laser ablation of F e2B target enriched in 10B content for boron neutron capture therapy. Laser Physics Letters. 2022;19:066002. https://doi.org/10.1088/1612-202y/ac642c.Aiyyzhy K, Barmina E, Zavestovskaya I, et al. Laser ablation of F e2B target enriched in 10B content for boron neutron capture therapy. Laser Physics Letters. 2022;19:066002. https://doi.org/10.1088/1612-202y/ac642c.Novopashina D, Dymova M, Davydova A, et al. Optamers for addressed boron delivery in BNCT: Effect of boron cluster attachment site on functional activity. Int J Molec Sci. 2023;24:306. https://doi.org/10.3390/ijms24010306.Novopashina D, Dymova M, Davydova A, et al. Optamers for addressed boron delivery in BNCT: Effect of boron cluster attachment site on functional activity. Int J Molec Sci. 2023;24:306. https://doi.org/10.3390/ijms24010306.Raskolupova V, Wang M, Dymova M, et al. Design of the new closo-dodecarborate-containing gemcitabine analogue for the albumin-based theranostics composition. Molecules. 2023;28:2672. https://doi.org/10.3390/molecules28062672.Raskolupova V, Wang M, Dymova M, et al. Design of the new closo-dodecarborate-containing gemcitabine analogue for the albumin-based theranostics composition. Molecules. 2023;28:2672. https://doi.org/10.3390/molecules28062672.Potseleev V, Uspenskii S, Trofimchuk E, et al. Nanocomposite Materials Based on Polylactide and Gold Com-2 plex Compounds for Absorbed Dose Diagnostics in BNCT. Int J Molec Sci. 24 (2023) 16492. https://doi.org/10.3390/ijms242216492.Potseleev V, Uspenskii S, Trofimchuk E, et al. Nanocomposite Materials Based on Polylactide and Gold Com-2 plex Compounds for Absorbed Dose Diagnostics in BNCT. Int J Molec Sci. 24 (2023) 16492. https://doi.org/10.3390/ijms242216492.Zavestovskaya I, Kasatova A, Kasatov D, et al. Laser-synthesized elemental boron nanoparticles for eĸcient boron neutron capture therapy. Int J Molec Sci. 2024;24:17088. https://doi.org/10.3390/ijms242317088Zavestovskaya I, Kasatova A, Kasatov D, et al. Laser-synthesized elemental boron nanoparticles for efficient boron neutron capture therapy. Int J Molec Sci. 2024;24:17088. https://doi.org/10.3390/ijms242317088Таскаева ЮС, Касатова АИ, Шатрук АЮ, Таскаев СЮ, Бгатова НП. Оценка экспрессии белков-маркеров острого повреждения почек Kim1 и NGAL после введения высоких доз лития карбоната у мышей с имплантированной меланомой кожи B16. Бюллетень экспериментальной биологии и медицины. 2023;176(11):579-84. https://doi.org/10.1007/s10517-024-06068-1.Taskaeva Yu, Kasatova A, Shatruk A, Taskaev S, Bgatova N. The Expression of Markers of Acute Kidney Injury Kim1 and NGAL after Administration of High Doses of Lithium Carbonate in Mice with Engrafted Skin Melanoma B16. Bulletin of Experimental Biology and Medicine. 2024;176(5):579-84. (In Russ.). https://doi.org/10.1007/s10517-024-06068-1.Taskaeva I, Kasatova A, Razumov I, et al. Lithium salts cytotoxicity and accumulation in melanoma cells in vitro. J Appl Toxicol. 2024;44(5):712-9. https://doi.org/10.1002/jat.4576.Taskaeva I, Kasatova A, Razumov I, et al. Lithium salts cytotoxicity and accumulation in melanoma cells in vitro. J Appl Toxicol. 2024;44(5):712-9. https://doi.org/10.1002/jat.4576.Касатова АИ, Разумов ИА, Таскаев СЮ, Таскаева ЮС. Сравнительная оценка цитотоксичности и накопления препаратов бора и лития в клетках меланомы кожи in vitro. Бюллетень экспериментальной биологии и медицины. 2024;177(6):717-22. https://doi.org/10.47056/0365-9615-2024-177-6-717-722.Kasatova AI, Razumov IA, Taskaev SYu, Taskaeva YuS. Comparative assessment of cytotoxicity and accumulation of boron and lithium preparations in skin melanoma cells in vitro. Bulletin of Experimental Biology and Medicine. 2024;177(6):717-22. (In Russ.). https://doi.org/10.47056/0365-9615-2024-177-6-717-722.Shoshin A, Burdakov A, Ivantsivskiy M, et al. Test results of boron carbide ceramics for ITER port protection. Fusion Engineering and Design. 2021;168:112426. https://doi.org/10.1016/j.fusengdes.2021.112426.Shoshin A, Burdakov A, Ivantsivskiy M, et al. Test results of boron carbide ceramics for ITER port protection. Fusion Engineering and Design. 2021;168:112426. https://doi.org/10.1016/j.fusengdes.2021.112426.Shoshin A, Burdakov A, Ivantsivskiy M, et al. Integration of ITER diagnostic ports at the Budker Institute. Fusion Engineering and Design. 2022;178:113114. https://doi.org/10.1016/j.fusengdes.2022.113114.Shoshin A, Burdakov A, Ivantsivskiy M, et al. Integration of ITER diagnostic ports at the Budker Institute. Fusion Engineering and Design. 2022;178:113114. https://doi.org/10.1016/j.fusengdes.2022.113114.Abdrashitov G, Kapitonov V, Kolesnikov Ia, et al. Compact Accelerator-Based Fast Neutron Source for the Radiation Testing of Promising Materials. Physics of Particles and Nuclei Letters. 2024;21(3):346-51. https://doi.org/10.1134/S1547477124700249.Abdrashitov G, Kapitonov V, Kolesnikov Ia, et al. Compact Accelerator-Based Fast Neutron Source for the Radiation Testing of Promising Materials. Physics of Particles and Nuclei Letters. 2024;21(3):346-51. https://doi.org/10.1134/S1547477124700249.Taskaev S, Bykov T, Kasatov D, et al. Measurement of the 7Li(p,p’ɶ)7Li reaction cross-section and 478 keV photon yield from a thick lithium target at proton energies from 0.65 MeV to 2.225 MeV. Nucl Instrum Meth Phys Res B. 2021;502:85-94. https://doi.org/10.1016/j.nimb.2021.06.010.Taskaev S, Bykov T, Kasatov D, et al. Measurement of the 7Li(p,p’ɶ)7Li reaction cross-section and 478 keV photon yield from a thick lithium target at proton energies from 0.65 MeV to 2.225 MeV. Nucl Instrum Meth Phys Res B. 2021;502:85-94. https://doi.org/10.1016/j.nimb.2021.06.010.Bikchurina M, Bykov T, Kasatov D, et al. The measurement of the neutron yield of the 7Li(p,n)7Be reaction in lithium targets. Biology. 2021;10:824. https://doi.org/10.3390/biology10090824.Bikchurina M, Bykov T, Kasatov D, et al. The measurement of the neutron yield of the 7Li(p,n)7Be reaction in lithium targets. Biology. 2021;10:824. https://doi.org/10.3390/biology10090824.Taskaev S, Bikchurina M, Bykov T, et al. Cross-section measurement for the 7Li(p,ɲ)4He reaction at proton energies 0.6 - 2 MeV. Nucl Instrum Meth Phys Res B. 2022;525:55-61. https://doi.org/10.1016/j.nimb.2022.06.010.Taskaev S, Bikchurina M, Bykov T, et al. Cross-section measurement for the 7Li(p,ɲ)4He reaction at proton energies 0.6 - 2 MeV. Nucl Instrum Meth Phys Res B. 2022;525:55-61. https://doi.org/10.1016/j.nimb.2022.06.010.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of cross-section of the 6Li(d,ɲ)4He, 6Li(d,p)7Li, 6Li(d,p)7Li* , 7Li(d,ɲ)5He, and 7Li(d,nɲ)4He reactions at the deuteron energies from 0.3 MeV to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;554:165460. https://doi.org/10.1016/j.nimb.2024.165460.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of cross-section of the 6Li(d,ɲ)4He, 6Li(d,p)7Li, 6Li(d,p)7Li* , 7Li(d,ɲ)5He, and 7Li(d,nɲ)4He reactions at the deuteron energies from 0.3 MeV to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;554:165460. https://doi.org/10.1016/j.nimb.2024.165460.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of the 11B(p,ɲ0)8Be and the 11B(p,ɲ1)8Be* reactions cross-sections at the proton energies up to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;555:165490. https://doi.org/10.1016/j.nimb.2024.165490.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of the 11B(p,ɲ0)8Be and the 11B(p,ɲ1)8Be* reactions cross-sections at the proton energies up to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;555:165490. https://doi.org/10.1016/j.nimb.2024.165490.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of the 10B(d,ɲ0)8Be, 10B(d,ɲ1)8Be* , 10B(d,p2)9Be* , 11B(d,ɲ0)9Be, and 11B(d,ɲ2)9Be* reactions cross-sections at the deuteron energies up to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;557:165527. https://doi.org/10.1016/j.nimb.2024.165527.Taskaev S, Bessmeltsev V, Bikchurina M, et al. Measurement of the 10B(d,ɲ0)8Be, 10B(d,ɲ1)8Be* , 10B(d,p2)9Be* , 11B(d,ɲ0)9Be, and 11B(d,ɲ2)9Be* reactions cross-sections at the deuteron energies up to 2.2 MeV. Nucl Instrum Meth Phys Res B. 2024;557:165527. https://doi.org/10.1016/j.nimb.2024.165527.Badrutdinov A, Bykov T, Gromilov S, et al. In situ Observations of Blistering of a Metal Irradiated with 2-MeV Protons. Metals. 2017;7(12);558. https://doi.org/10.3390/met7120558.Badrutdinov A, Bykov T, Gromilov S, et al. /n ^itu Observations of Blistering of a Metal Irradiated with 2-MeV Protons. Metals. 2017;7(12);558. https://doi.org/10.3390/met7120558.Касатов ДА, Кошкарев АМ, Макаров АН и др. Источник быстрых нейтронов на основе ускорителя-тандема с вакуумной изоляцией и литиевой мишени. Приборы и техника эксперимента. 2020;5:5-9. https://doi.org/10.1134/S0020441220050152.Kasatov D, Koshkarev A, Makarov A, et al. A fast-neutron source based on a vacuum-insulated tandem accelerator and a lithium target. Instruments and Experimental Techniques. 2020;63(5):611–5. (In Russ.). https://doi.org/10.1134/S0020441220050152.Kasatov D, Kolesnikov Ia, Koshkarev A, et al. Method for in situ measuring the thickness of a lithium layer. Journal of Instrumentation. 2020;15:P10006. https://doi.org/10.1088/1748-0221/15/10/P10006.Kasatov D, Kolesnikov Ia, Koshkarev A, et al. Method for in situ measuring the thickness of a lithium layer. Journal of Instrumentation. 2020;15:P10006. https://doi.org/10.1088/1748-0221/15/10/P10006.Bykov T, Goloshevskii N, Gromilov S, et al. /n situ study of the blistering effect of copper with a thin lithium layer on the neutron yield in the 7Li(p,n)7Be reaction. Nucl Instrum Meth Phys Res B. 2020;481:62-81. https://doi.org/10.1016/j.nimb.2020.08.010.Bykov T, Goloshevskii N, Gromilov S, et al. /n situ study of the blistering effect of copper with a thin lithium layer on the neutron yield in the 7Li(p,n)7Be reaction. Nucl Instrum Meth Phys Res B. 2020;481:62-81. https://doi.org/10.1016/j.nimb.2020.08.010.Svishcheva N, Uspenskii S, Sedush N, et al. Biodegradable boron-containing poly(lactic acid) for fertilizers with prolonged action. Materials Today Communications 33 (2022) 104514. https://doi.org/10.1016/j.mtcomm.2022.104514.Svishcheva N, Uspenskii S, Sedush N, et al. Biodegradable boron-containing poly(lactic acid) for fertilizers with prolonged action. Materials Today Communications 33 (2022) 104514. https://doi.org/10.1016/j.mtcomm.2022.104514.Romashchenko A, Petrovskii D, Trotsky S, et al. Yuantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor, aging, and Parkinson’s disease. Nano Res. 2023;16(5):7119-33. https://doi.org/10.1007/s12274-022-5302-6.Romashchenko A, Petrovskii D, Trotsky S, et al. Yuantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor, aging, and Parkinson’s disease. Nano Res. 2023;16(5):7119-33. https://doi.org/10.1007/s12274-022-5302-6.Dyusenova S, Klyamer D, Sukhikh A, et al. InŇuence of Magnetic Field on the Structure and Sensor Properties of Thin Titanyl Phthalocyanine Layers. J Struct Chem. 2023;64(3):337-46. https://doi.org/10.1134/S0022476623030010.Dyusenova S, Klyamer D, Sukhikh A, et al. InŇuence of Magnetic Field on the Structure and Sensor Properties of Thin Titanyl Phthalocyanine Layers. J Struct Chem. 2023;64(3):337-46. https://doi.org/10.1134/S0022476623030010.Касатов Д.А. Исследование материалов нейтроногенерирующей мишени для бор-нейтронозахватной терапии. Дис. канд. физ.-мат. наук. Новосибирск. 2022. 143 с.Kasatov DA. Study of materials of neutron-generating target for boron neutron capture therapy. Author’s abstract of thesis PhD. Novosibirsk. 2022. 143 p. (In Russ.).Соколова Е.О. Исследование и оптимизация тонкой литиевой мишени для генерации нейтронов. Дис. канд. физ.-мат. наук. Новосибирск. 2022. 127 с.Sokolova EO. Research and optimization of a thin lithium target for neutron generation. Author’s abstract of thesis PhD. Novosibirsk. 2022. 127 p. (In Russ.).Бикчурина М.И. Исследование генерирующих свойств литиевой мишени. Дис. канд. физ.-мат. наук. Новосибирск. 2024. 138 с.Bikchurina MI. Study of generating properties of a lithium target. Author’s abstract of thesis PhD. Novosibirsk. 2024. 138 p. (In Russ.).Zaidi L, Kashaeva E, Lezhnin S, et al. Neutron-Beam-Shaping Assembly for Boron Neutron-Capture Therapy. Physics of Atomic Nuclei. 2017;80(1):60-6. https://doi.org/10.1134/S106377881701015y.Zaidi L, Kashaeva E, Lezhnin S, et al. Neutron-Beam-Shaping Assembly for Boron Neutron-Capture Therapy. Physics of Atomic Nuclei. 2017;80(1):60-6. https://doi.org/10.1134/S106377881701015y.Zaidi L, Belgaid M, Taskaev S, Khelifi R. Beam Shaping Assembly Design of 7Li(p,n)7Be Neutron Source for Boron Neutron Capture Therapy of Deep-seated Tumor. Appl Radiat Isotop. 2018;139:316-24. https://doi.org/10.1016/j.apradiso.2018.05.029.Zaidi L, Belgaid M, Taskaev S, Khelifi R. Beam Shaping Assembly Design of 7Li(p,n)7Be Neutron Source for Boron Neutron Capture Therapy of Deep-seated Tumor. Appl Radiat Isotop. 2018;139:316-24. https://doi.org/10.1016/j.apradiso.2018.05.029.https://www.conicet.gov.ar/newͺscp/detalle.php͍?key-words=&idс20599Θcongresosс=yes&detalles=yes&congrͺidс10189175.https://www.conicet.gov.ar/new_scp/detalle.php?key‑wordsс=&id=20599&congresos=yes&detalles=yes&congr_id=10189175Kobayashi T, Kanda K. Microanalysis system of ppm order B-10 concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry. Nucl Instrum Meth Phys Res 1983;204:525-31. https://doi.org/10.1016/0167-5087(83)90082-0.Kobayashi T, Kanda K. Microanalysis system of ppm order B-10 concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry. Nucl Instrum Meth Phys Res 1983;204:525-31. https://doi.org/10.1016/0167-5087(83)90082-0.Green S, Phoenix B, Nakamura S, et al. Accelerator neutron sources for BNCT: current status and some pointers for future development. Appl Radiat Isotop. 2025 (under review).Green S, Phoenix B, Nakamura S, et al. Accelerator neutron sources for BNCT: current status and some pointers for future development. Appl Radiat Isotop. 2025 (under review).

The authors declare that there are no conflicts of interest present.