ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2024-7-4-13-18ojrdrt-395Research ArticleЛУЧЕВАЯ ТЕРАПИЯRADIOTHERAPYЭффективность бор-нейтронозахватной терапии в лечении больных глиальными опухолями головного мозга. Систематический обзор литературыGlial Brain Tumors BNCT Treatment Efficacy. A Systematic Reviewhttps://orcid.org/0000-0003-3028-7578ИвановВ. А.IvanovV. A.

Валерий Анатольевич Иванов

Россия, 115478 Москва, Каширское шоссе, 24 

Valerii A. Ivanov 

24 Kashirskoe Shosse, Moscow, Russia 115478 

dr.valeryivanov@gmail.comhttps://orcid.org/0000-0003-4944-4035ЧерныхМ. В.ChernykhM. V.

Россия, 115478 Москва, Каширское шоссе, 24 

24 Kashirskoe Shosse, Moscow, Russia 115478 

https://orcid.org/0009-0008-3486-302XГеворкянТ. Г.GevorkyanT. G.

Россия, 115478 Москва, Каширское шоссе, 24 

24 Kashirskoe Shosse, Moscow, Russia 115478 

Национальный медицинский исследовательский центp онкологии им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian Federation202426122024741318Copyright © Иванов В.А., Черных М.В., Геворкян Т.Г., 20242024Иванов В.А., Черных М.В., Геворкян Т.Г.Ivanov V.A., Chernykh M.V., Gevorkyan T.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/395

Цель: Бор-нейтронозахватная терапия (БНЗТ) — многообещающий и перспективный метод лечения пациентов, в том числе больных глиальными опухолями головного мозга высокой степени злокачественности. С уч̘ётом планируемого введения в эксплуатацию ускорительного источника нейтронов в НМИˉ онкологии им. Н.Н. Блохина Минздрава России целью обзора являлась актуализация результатов эффективности перспективного метода лечения.Материал и методы: Провед̘ён поиск литературы с целью выявления результатов ретроспективных (с числом анализированных пациентов не менее 30) и исследований I и II фаз в базе данных Pubmed.Результаты: Из найденных 58 публикаций критериям поиска соответствовали 8 работ: ретроспективное исследование, 5 публикаций данных I фаз исследований и 2 статьи с результатами II фаз исследований. Анализ указанных работ указывает на низкий уровень методологии проведения клинических исследований эффективности БНЗТ и невозможность рекомендовать метод для рутинной практики.Выводы: Для использования БНЗТ в качестве стандартного метода лечения пациентов с глиальными опухолями головного мозга высокой степени злокачественности требуется проведение клинических исследований с соответствующим высоким уровнем методологии.

Purpose: Boron neutron capture therapy is a promising and prospective treatment method, including patients with high-grade glial brain tumors. Taking into account the planned bringing into service of a neutron source accelerator at the N.N. Blokhin National Medical Research Center of Oncology, the objective of the review was to update the current status of the effectiveness of a prospective treatment method.Material and methods: A literature search was conducted to identify results of retrospective (with at least 30 patients analyzed) and phase I and II studies in the Pubmed database.Results: Of the 58 publications found, 8 papers met the search criteria: a retrospective study, 5 phase I studies, and 2 articles with the results of phase II studies. An analysis of these works indicates a low level of methodology for conducting clinical studies of the BNCT effectiveness thus impossibility to recommend the method for routine practice.Conclusion: Clinical trials with an appropriate level of methodology are required to recommend BNCT for patients with high-grade glial brain tumors as a standard treatment.

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The authors declare that there are no conflicts of interest present.