<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ojrdrt</journal-id><journal-title-group><journal-title xml:lang="ru">Онкологический журнал: лучевая диагностика, лучевая терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of oncology: diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7593</issn><issn pub-type="epub">2713-167X</issn><publisher><publisher-name>НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37174/2587-7593-2024-7-2-46-54</article-id><article-id custom-type="elpub" pub-id-type="custom">ojrdrt-363</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛУЧЕВАЯ ДИАГНОСТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIAGNOSTIC RADIOLOGY</subject></subj-group></article-categories><title-group><article-title>Внутрилегочные лимфатические узлы у пациентов с солидными опухолями внелегочной локализации</article-title><trans-title-group xml:lang="en"><trans-title>Intrapulmonary Lymph Nodes in Patients with Extrapulmonary Solid Tumors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5434-0383</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бяхова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Biakhova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бяхова Валерия Александровна — врач-рентгенолог отделения рентгенодиагностики отдела лучевых методов диагностики опухолей консультативно-диагностического центра НМИЦ онкологии им. Н.Н. Блохина Минздрава России.</p><p>115478 Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Valeriya A. Biakhova.</p><p>24 Kashirskoye Shosse, Moscow, 115478</p></bio><email xlink:type="simple">byakhova.valeriia@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3931-1431</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюрин</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Turin</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тюрин Игорь Евгеньевич — врач-рентгенолог, д.м.н., профессор, заместитель директора по научной работе НИИ клинической и экспериментальной радиологии НМИЦ онкологии им. Н.Н. Блохина Минздрава России, главный внештатный специалист по лучевой и инструментальной диагностике Минздрава России.</p><p>115478 Москва, Каширское шоссе, 24</p></bio><bio xml:lang="en"><p>Igor E. Turin.</p><p>24 Kashirskoye Shosse, Moscow, 115478</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin National Medical Research Center of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>04</day><month>07</month><year>2024</year></pub-date><volume>7</volume><issue>2</issue><fpage>46</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бяхова В.А., Тюрин И.Е., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Бяхова В.А., Тюрин И.Е.</copyright-holder><copyright-holder xml:lang="en">Biakhova V.A., Turin I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.oncoradjournal.ru/jour/article/view/363">https://www.oncoradjournal.ru/jour/article/view/363</self-uri><abstract><sec><title>Цель</title><p>Цель: Уточнить возможность возникновения метастатического поражения внутрилегочных лимфоузлов у пациентов со злокачественными новообразованиями внелегочной локализации на анализе ретроспективного и проспективного материла.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: В исследование было включено 139 пациентов. Критерием отбора больных был подтверждённый морфологически онкологический диагноз и наличие очагов в легких. Больные были набраны из двух больших групп ведущих локализаций в общей структуре онкологической заболеваемости: группа пациентов с колоректальным раком — 76 (54,7 %) и группа пациентов со злокачественными опухолями молочной железы — 63 (45,3 %). Всего у 139 пациентов было выявлено и проанализировано 312 очагов в легких. Высокоразрешающая компьютерная томография (ВРКТ) с толщиной среза до 1-1,5 мм органов грудной клетки была выполнена у всех пациентов. Оценка динамики у всех больных проводилась в течение не менее 3 лет.</p></sec><sec><title>Результаты</title><p>Результаты: Из 139 пациентов с впервые выявленными очагами в легких у 43 (30,9 %) пациентов были выявлены очаги, отнесенные нами к группе внутрилегочных лимфоузлов (ВЛУ). Всего было выявлено 75 (24,0 %) очагов, отнесенных к типичным или атипичным ВЛУ. Нами были получены следующие данные: ВЛУ располагались преимущественно в нижних долях — 46,7 %, 84 % ВЛУ локализовались ниже карины. Всего 37,3 % очагов относились к перифиссуральным очагам, 62,7 % выявленных очагов были отнесены к субплевральным (периплевральным) очагам. Установлено, что ВЛУ локализовались на плевре или имели связь с ней посредством тонкой перегородки — 49,3 % и 38,7 % соответственно. Средний диаметр ВЛУ в легком составлял 4,0 мм. ВЛУ имели треугольную форму в 64 %, округлую (чечевицеобразную) — 21,3 % и овальную — в 14,7 % случаев. 96 % очагов, отнесённых нами к группе ВЛУ, были проконтролированы в динамике с по­мощью ВРКТ в течение 3 лет и более, 4 % очагов подверглись хирургическому лечению. Все очаги, которые мы наблюдали в течение 3 лет, оставались без динамики. Исходя из полученных данных, был сделан вывод, что ВЛУ у пациентов с солидными опухолями внелегочной локации и очагами в легких, являются доброкачественными изменениями и не требуют динамического контроля.</p></sec><sec><title>Выводы</title><p>Выводы: Показано, что очаги у пациентов в солидными опухолями внелегочной локализации, отнесенные к группе ВЛУ, являются доброкачественными изменениями и не влияют на стадию и характер проводимого лечения, а также не требуют динамического контроля.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: To clarify the possibility of metastatic lesions of intrapulmonary lymph nodes in patients with malignant neoplasms of extrapulmonary localization by analyzing retrospective and prospective material.</p></sec><sec><title>Material and methods</title><p>Material and methods: Our study included 139 patients. The criterion for selecting patients was a morphologically confirmed on­cological diagnosis and the presence of lesions in the lungs. Patients were recruited from two large groups of leading localizations in the general structure of cancer incidence: a group of patients with colorectal cancer — 76 (54.7 %) and a group of patients with malignant breast tumors — 63 (45.3 %). A total of 312 lung lesions were identified and analyzed in 139 patients. High-resolution computed tomography with a slice thickness of up to 1-1.5 mm of the chest was performed in all patients. Assessment of dynamics in all patients was carried out for at least 3 years.</p></sec><sec><title>Results</title><p>Results: As a result, out of 139 patients with newly detected lesions in the lungs, 43 (30.9 %) patients had lesions identified, which we classified as intrapulmonary regional lymph nodes (RLNs). A total of 75 (24.0 %) lesions classified as typical or atypical RLNs were identified. We obtained the following data: RLNs were located predominantly in the lower lobes — 46.7 %, 84 % of RLNs were localized below the carina. A total of 37.3 % of lesions were classified as perifissural lesions, 62.7 % of identified lesions were classified as subpleural (peripleural) lesions. It was found that the RLNs were localized on the pleura or had a connection with it through a thin septum — 49.3 % and 38.7 %, respectively. The average diameter of the RLN in the lung was 4.0 mm. RLNs were triangular in shape in 64 %, round (lenticular) in 21.3 %, and oval in 14.7 % of cases. 96 % of the lesions we classified as RLN were monitored over time using HRCT for 3 years or more, 4 % of the lesions underwent surgical treatment. All the lesions that we observed over the course of 3 years remained without dynamics. Based on the data obtained, we concluded that RLNs in patients with solid tumors of extrapulmonary locations and lesions in the lungs are benign changes and do not require dynamic monitoring.</p></sec><sec><title>Conclusions</title><p>Conclusions: Lesions in patients with solid tumors of extrapulmonary localization classified as RLN are benign changes and do not affect the stage and nature of the treatment, and also do not require dynamic monitoring.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>внутрилегочные лимфатические узлы</kwd><kwd>доброкачественные очаги в легких</kwd><kwd>пациенты с опухолями внелегочной локализации</kwd><kwd>компьютерная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intrapulmonary regional lymph nodes</kwd><kwd>benign lesions in the lungs</kwd><kwd>patients with tumors of extrapulmonary localization</kwd><kwd>oncological patients</kwd><kwd>computed tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тюрин И.Е. Компьютерная томография органов грудной полости. СПб.: 2003. 371 с.</mixed-citation><mixed-citation xml:lang="en">Tyurin IE. Computed tomography of the chest organs. St. Petersburg: 2003. 371 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гринберг ЛМ, Валамина ИЕ, Коротков ПБ, Мещерякова ЕЮ. Внутрилегочные лимфатические узлы: патология и проблемы диагностики. Уральский медицинский журнал. 2018;2(157):77-9.</mixed-citation><mixed-citation xml:lang="en">Grinberg LM, Valamina IE, Korotkov PB, Meshcheryakova EYu. Intrapulmonary lymph nodes: pathology and diagnostic problems. Ural Medical Journal. 2018;2(157):77-9. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberg HB. Benign subpleural lymph node appearing as a pulmonary ‘coin' lesion. Radiology. 1961;77-97. https://doi.org/10.1148/77.1.97</mixed-citation><mixed-citation xml:lang="en">Greenberg HB. Benign subpleural lymph node appearing as a pulmonary ‘coin' lesion. Radiology. 1961;77-97. https://doi.org/10.1148/77.1.97</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Schreuder A, Colin J, Scholten ET. Typical CT Features of Intrapulmonary Lymph Nodes: A Review. Radiology: Cardiothoracic Imaging. 2020; 2(4):e190159. https://doi.org/10.1148/ryct.2020190159.</mixed-citation><mixed-citation xml:lang="en">Schreuder A, Colin J, Scholten ET. Typical CT Features of Intrapulmonary Lymph Nodes: A Review. Radiology: Cardiothoracic Imaging. 2020; 2(4):e190159. https://doi.org/10.1148/ryct.2020190159.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn MI, Gleeson TG, Chan IH. Perifissural Nodules Seen at CT Screening for Lung Cancer. Radiology. 2010;254(3). https://doi.org/10.1148/radiol.09090031</mixed-citation><mixed-citation xml:lang="en">Ahn MI, Gleeson TG, Chan IH. Perifissural Nodules Seen at CT Screening for Lung Cancer. Radiology. 2010;254(3). https://doi.org/10.1148/radiol.09090031</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">de Hoop B, van Ginneken B, Gietema H, Prokop M. Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of malignancy. Radiology. 2012;265(2):611-6. https://doi.org/10.1148/radiol.12112351</mixed-citation><mixed-citation xml:lang="en">de Hoop B, van Ginneken B, Gietema H, Prokop M. Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of malignancy. Radiology. 2012;265(2):611-6. https://doi.org/10.1148/radiol.12112351</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Golia Pernicka JS, Hayes SA, Schor-Bardach R, et al. Clinical significance of perifissural nodules in the oncologic population. Clin Imaging. 2019; 57:110-4. https://doi.org/10.1016/j.clinimag.2019.05.017</mixed-citation><mixed-citation xml:lang="en">Golia Pernicka JS, Hayes SA, Schor-Bardach R, et al. Clinical significance of perifissural nodules in the oncologic population. Clin Imaging. 2019; 57:110-4. https://doi.org/10.1016/j.clinimag.2019.05.017</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kastner J, Hossain R, Jeudy J. Lung-RADS Version 1.0 versus Lung-RADS Version 1.1: Comparison of Categories Using Nodules from the National Lung Screening Trial. Radiology. 2021;300:199-206. https://doi.org/10.1148/radiol.2021203704</mixed-citation><mixed-citation xml:lang="en">Kastner J, Hossain R, Jeudy J. Lung-RADS Version 1.0 versus Lung-RADS Version 1.1: Comparison of Categories Using Nodules from the National Lung Screening Trial. Radiology. 2021;300:199-206. https://doi.org/10.1148/radiol.2021203704</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mets OM, Chung K, Scholten ET, et al. Incidental perifissural nodules on routine chest computed tomography: lung cancer or not? Eur Radiol. 2018; 28:1095-01. https://doi.org/10.1007/s00330-017-5055-x</mixed-citation><mixed-citation xml:lang="en">Mets OM, Chung K, Scholten ET, et al. Incidental perifissural nodules on routine chest computed tomography: lung cancer or not? Eur Radiol. 2018; 28:1095-01. https://doi.org/10.1007/s00330-017-5055-x</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Li WL, Ju JM, Liu GH, et al. A comparative study on radiology and pathology target volume in non-small cell lung cancer. 2003;25(6):566-8. PMID: 14690563</mixed-citation><mixed-citation xml:lang="en">Li WL, Ju JM, Liu GH, et al. A comparative study on radiology and pathology target volume in non small cell lung cancer. 2003;25(6):566-8. PMID: 14690563</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sieren JC. A process model for direct correlation between computed tomography and histopathology: application in lung cancer. Acad. Radiol. 2010;17(2):169-80. https://doi.org/10.1016/j.acra.2009.09.006</mixed-citation><mixed-citation xml:lang="en">Sieren JC. A process model for direct correlation between computed tomography and histopathology: application in lung cancer. Acad. Radiol. 2010;17(2):169-80. https://doi.org/10.1016/j.acra.2009.09.006</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Onozato ML. A role of three-dimensional (3D) reconstruction in the classification of lung adenocarcinoma. Studies in Health Technology and Informatics. 2012;179:250-6. https://doi.org/10.3233/ACP-2011-0030</mixed-citation><mixed-citation xml:lang="en">Onozato ML. A role of three-dimensional (3D) reconstruction in the classification of lung adenocarcinoma. Studies in Health Technology and Informatics. 2012;179:250-6. https://doi.org/10.3233/ACP-2011-0030</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Grills IS, Fitch DL, Goldstein NS, et al. Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: defining clinical target volume for radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69(2):334-41. https://doi.org/10.1016/j.ijrobp.2007.03.023</mixed-citation><mixed-citation xml:lang="en">Grills IS, Fitch DL, Goldstein NS, et al. Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: defining clinical target volume for radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69(2):334-41. https://doi.org/10.1016/j.ijrobp.2007.03.023</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chan R, He Y, Haque A, Zwischenberger J.. Computed tomographic-pathologic correlations of gross tumor volume and clinical target volume in nonsmall cell lung cancer: a pilot experience. Arch Pathol Lab Med. 2001;125(11):1469-72. https://doi.org/10.5858/2001-125-1469-CTPCOG</mixed-citation><mixed-citation xml:lang="en">Chan R, He Y, Haque A, Zwischenberger J.. Computed tomographic-pathologic correlations of gross tumor volume and clinical target volume in non-small cell lung cancer: a pilot experience. Arch Pathol Lab Med. 2001;125(11):1469-72. https://doi.org/10.5858/2001-125-1469-CTPCOG</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">van de Steen J, Linthout N, de Mey J. Definition of gross tumor volume in lung cancer: inter-observer variability. Radiotherapy Oncol. 2002;62(1):37-49. https://doi.org/10.1016/S0167-8140(01)00453-4</mixed-citation><mixed-citation xml:lang="en">van de Steen J, Linthout N, de Mey J. Definition of gross tumor volume in lung cancer: inter-observer variability. Radiotherapy Oncol. 2002;62(1):37-49. https://doi.org/10.1016/S0167-8140(01)00453-4</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Пинчук СВ. О поражении внутрилегочных лимфатических узлов при раке легкого. Оренбургский медицинский вестник. 2019;(3):11.</mixed-citation><mixed-citation xml:lang="en">Pinchuk SV. On the defeat of the intrapulmonary lymph nodes in lung cancer. Orenburg Medical Bulletin. 2019;(3):11. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
