ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2022-5-2-18-34ojrdrt-231Research ArticleЯДЕРНАЯ МЕДИЦИНАNUCLEAR MEDICINEВозможности методов ядерной медицины в диагностике воспаленияThe Possibilities of Nuclear Medicine Methods in Inflammation Diagnosishttps://orcid.org/0000-0003-1308-7646СветляковаА. В.SvetlyakovaA. V.

Светлякова Анастасия Викторовна — клинический ординатор

115478, Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478

https://orcid.org/0000-0002-8476-7879КрыловА. С.KrylovA. S.

Крылов Александр Сергеевич — заведующий лабораторией, врач-радиолог, к.м.н. SPIN-код: 4254-3930, AuthorID: 723683

115478, Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478

krilovas@rambler.ruhttps://orcid.org/0000-0002-9571-801XРыжковА. Д.RyzhkovA. D.

Рыжков Алексей Дмитриевич — в.н.с., врач-радиолог, д.м.н.

115478, Москва, Каширское шоссе, 24125993, Москва, ул. Баррикадная, 2/1, стр. 1

24 Kashirskoye Highway, Moscow, 115478Build. 1, 2/1, Barricadnaya str., Moscow, 125993

https://orcid.org/0000-0002-7954-2560НиколаеваЕ. А.NikolaevaE. A.

Николаева Екатерина Андреевна — клинический ординатор

115478, Москва, Каширское шоссе, 24125993, Москва, ул. Баррикадная, 2/1, стр. 1

24 Kashirskoye Highway, Moscow, 115478Build. 1, 2/1, Barricadnaya str., Moscow, 125993

https://orcid.org/0000-0001-7226-5129ТулинП. Е.TulinP. E.

Тулин Павел Евгеньевич — врач-радиолог, к.м.н., SPIN-код: 6978-1315

115478, Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478

https://orcid.org/0000-0003-3576-6156ОджароваА. А.OdzharovaA. A.

Оджарова Акгуль Атаевна — с.н.с., врач-радиолог, к.м.н., SPIN-код: 1074-3862

115478, Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478

https://orcid.org/0000-0003-1632-351XПронинА. И.ProninA. I.

Пронин Артем Игоревич — руководитель отдела, заведующий отделением, врач-радиолог, к.м.н., SPIN-код: 2833-8191

115478, Москва, Каширское шоссе, 24

24 Kashirskoye Highway, Moscow, 115478

Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationНациональный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России; Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of Oncology; Russian Medical Academy of Continuous Professional EducationRussian Federation202225062022521834Copyright © Светлякова А.В., Крылов А.С., Рыжков А.Д., Николаева Е.А., Тулин П.Е., Оджарова А.А., Пронин А.И., 20222022Светлякова А.В., Крылов А.С., Рыжков А.Д., Николаева Е.А., Тулин П.Е., Оджарова А.А., Пронин А.И.Svetlyakova A.V., Krylov A.S., Ryzhkov A.D., Nikolaeva E.A., Tulin P.E., Odzharova A.A., Pronin A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/231

Современная ядерная медицина представляет собой активно развивающийся раздел медицинской радиологии, который включает в себя различные неинвазивные методы медицинской визуализации с возможностью обследования всего тела.

Воспаление — частое осложнение в хирургической и травматологической практиках, представляющее собой комплексный, местный и общий патологический процесс, протекающий в организме в ответ на повреждение. Возникнув под влиянием повреждающего фактора, воспаление характеризуется развитием динамичного комплекса изменений. Однако поиск очагов воспаления традиционными методами диагностики в ряде случаев затруднителен даже при развернутой клинической картине. В этом случае оптимальным вариантом для поиска области поражения может выступить ядерная медицина, способная визуализировать патологические процессы, в том числе с патологическим усилением метаболизма.

Широкое разнообразие радиофармацевтических лекарственных препаратов (РФЛП) позволяет в короткие сроки и с высокой точностью определять локализацию воспалительного очага и делает методы ядерной визуализации приоритетными для ранней диагностики патофизиологических реакций.

В настоящей работе представлен обзор отечественной и зарубежной литературы по использованию специфических и неспецифических РФЛП в диагностике воспаления. Также представлены примеры собственных исследований.

Modern nuclear medicine is a rapidly developing field that includes various non-invasive molecular imaging techniques with the ability to examine the whole body.

Inflammation is a frequent complication in surgical and traumatological practices, which is a complex, local and general pathological process that occurs in the body in response to injury. Having arisen under the influence of a damaging factor, inflammation is characterized by the development of a dynamic complex of changes. However, the search for inflammation foci of inflammation by traditional diagnostic methods in some cases is difficult even with a detailed clinical picture. In this case, nuclear medicine, which is able to visualize pathological processes, including those with a pathological increase in metabolism, may be the best option for finding the affected area.

A wide variety of radiopharmaceutical drugs makes it possible to determine the localization of the inflammatory focus in a short time and with high accuracy and makes nuclear imaging methods a priority for the early diagnosis of pathophysiological reactions.

This paper presents a review of domestic and foreign literature on the use of specific and nonspecific radiopharmaceuticals in the diagnosis of inflammation. Own cases is also presented.

ядерная медицинавоспалениеРФЛПОФЭКТ/КТПЭТ/КТnuclear medicineinflammationradiopharmaceuticalsSPECT/CTPET/CTReferencesStephenson TJ. Inflammation. General and systematic pathology. Ed. J.C.E. Elsevier. London: Underwood. 2004;202-20.Stephenson TJ. Inflammation. General and systematic pathology. Ed. J.C.E. Elsevier. London: Underwood. 2004;202-20.Elgazzar AH, Dannoon S, Sarikaya I, Farghali M, Junaid TA. Scintigraphic Patterns of Indium-111 Oxine-Labeled White Blood Cell Imaging of Gram-Negative versus Gram-Positive Vertebral Osteomyelitis. Med Princ Pract. 2017;26(5):415-20. DOI: 10.1159/000480083.Elgazzar AH, Dannoon S, Sarikaya I, Farghali M, Junaid TA. Scintigraphic Patterns of Indium-111 Oxine-Labeled White Blood Cell Imaging of Gram-Negative versus Gram-Positive Vertebral Osteomyelitis. Med Princ Pract. 2017;26(5):415-20. DOI: 10.1159/000480083.Куражов АП, Завадовская ВД, Килина ОЮ и др. Использование 199Tl-хлорида и 99mTc-МИБИ для индикации и дифференциальной диагностики опухолевых и воспалительных процессов опорно-двигательного аппарата. Бюллетень сибирской медицины. 2012;11(3):120-31. DOI: 10.20538/1682-0363-2012-3-120-131.Kurazhov AP, Zavadovskaya VD, Kilina OYu, et al. The use of 199Tl-chloride and 99mTc-MIBI for the indication and differential diagnosis of tumor and inflammatory processes in the musculoskeletal system. Bulletin of Siberian Medicine. 2012;11(3):120-31. (In Russian). DOI: 10.20538/1682-0363-2012-3-120-131.Куражов АП, Завадовская ВД, Чойнзонов ЕЛ и др. Возможности использования неспецифичных туморотропных индикаторов 99m TcМИБИ, 67Ga-цитрата и 199Tl-хлорида для дифференциальной диагностики злокачественных опухолей. Сибирский онкологический журнал. 2012;53(5):5-11.Kurazhov AP, Zavadovskaya VD, Choinzonov EL, et al. Possibilities of using nonspecific tumoritropic indicators 99mTc-MIBI, 67Ga-citrate and 199Tl-chloride for differential diagnosis of malignant tumors. Siberian Journal of Oncology. 2012;53(5):5-11. (In Russian).Крылов АС, Ширяев СВ, Поляков ВГ и др. Сравнительная оценка возможности сцинтиграфии с 67Ga-цитратом и 99mTc-технетрилом при злокачественных мезенхимальных опухолях мягких тканей у детей. Медицинская радиология и радиационная безопасность. 2010;55(3):63-8.Krylov AS, Shiryaev SV, Polyakov VG, et al. Comparative evaluation of the possibility of scintigraphy with 67Ga-citrate and 99mTc-technetrile in malignant mesenchymal soft tissue tumors in children. Medical Radiology and Radiation Safety. 2010;55(3):63-8. (In Russian).Крылов АС, Поляков ВГ, Ширяев СВ. Оценка эффективности лечения сарком мягких тканей у детей при помощи сцинтиграфии с 99m Tcтехнетрилом и 67Ga-цитратом. Онкопедиатрия. 2014;(2):42-8.Krylov AS, Polyakov VG, Shiryaev SV. Evaluation of the effectiveness of the treatment of soft tissue sarcomas in children using scintigraphy with 99mTc-technetrile and 67Ga-citrate. Oncopediatrics. 2014;(2):42-8. (In Russian).Bombardieri E, Aktolun C, Baum RP, et al. 67Ga scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging. 2003;30(12):125-31.Bombardieri E, Aktolun C, Baum RP, et al. 67Ga scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging. 2003;30(12):125-31.Harris WR, Pecoraro VL. Estimation of the ferrous — transferrin binding constants based on thermodynamic studies of nickel (II) — transferrin. J Inorg Biochem. 1986;27:41-52.Harris WR, Pecoraro VL. Estimation of the ferrous — transferrin binding constants based on thermodynamic studies of nickel (II) — transferrin. J Inorg Biochem. 1986;27:41-52.Vorster M, Buscombe J, Saad Z, Sathekge M. Past and Future of Ga-citrate for Infection and Inflammation Imaging. Curr Pharm Des. 2018;24(7):787-94.Vorster M, Buscombe J, Saad Z, Sathekge M. Past and Future of Ga-citrate for Infection and Inflammation Imaging. Curr Pharm Des. 2018;24(7):787-94.Рыжков АД, Крылов АС, Каспшик СМ и др. Дифференциальная диагностика единичного очагового поражения скелета методом ОФЭКТ/ КТ. Онкологический журнал: лучевая диагностика, лучевая терапия. 2021;4(3):9-17.Ryzhkov AD, Krylov AS, Kaspshik SM, et al. Differential diagnosis of a single focal skeletal lesion by SPECT/ CT. Journal of Oncology: Radiation Diagnostics, Radiation Therapy. 2021;4(3):9-17. (In Russian).Рыжков АД, Крылов АС, Блудов АБ, Ширяев СВ. Остеосцинтиграфия и ОФЭКТ/КТ в диагностике различных вариантов метастатического поражения костей. Медицинская радиология и радиационная безопасность. 2018;63(2):41-6.Ryzhkov AD, Krylov AS, Bludov AB, Shiryaev SV. Bone scintigraphy and SPECT/CT in the diagnosis of various types of metastatic bone lesions. Medical Radiology and Radiation Safety. 2018;63(2):41-6. (In Russian).Кодина ГЕ. Остеотропные радиофармацевтические препараты в технологиях российской ядерной медицины. Известия Академии наук. Серия химическая. 2016;2.Kodina GE. Osteotropic radiopharmaceuticals in the technologies of Russian nuclear medicine. Proceedings of the Academy of Sciences. Series Chemical. 2016;2. (In Russian).Завадовская ВД, Килина ОЮ, Дамбаев ГЦ. Радионуклидные методы исследования в диагностике хронического остеомиелита. Медицинская радиология и радиационная безопасность. 2007;52(3):54-60.Zavadovskaya VD, Kilina OYu, Dambaev GT. Radionuclide research methods in the diagnosis of chronic osteomyelitis. Medical Radiology and Radiation Safety. 2007;52(3):54-60. (In Russian).Rennen HJ, Boerman OC, Wymenga AB, et al. 99mTc-labeled interleukin 8 for the scintigraphic detection of infection and inflammation: first clinical evaluation. J Nucl Med. 2007;48(3):337-43.Rennen HJ, Boerman OC, Wymenga AB, et al. 99mTc-labeled interleukin 8 for the scintigraphic detection of infection and inflammation: first clinical evaluation. J Nucl Med. 2007;48(3):337-43.Каспшик СМ, Долгушин МБ, Артамонова ЕВ, и др. Клиническое применение сцинтиграфии и ОФЭКТ/КТ с препаратом 99m Тс-тектротид у пациентов с нейроэндокринными опухолями. Медицинский алфавит. 2020;(20):42-5.Kaspshik SM, Dolgushin MB, Artamonova EV, Markovich AA, et al. Clinical application of scintigraphy and SPECT/CT with 99mTc-Tectrotide in patients with neuroendocrine tumors. Medical Alphabet. 2020;(20):42-5. (In Russian).Olias G, Viollet C, Kusserow H, Epelbaum J, Meyerhof W. Regulation and function of somatostatin receptors. J Neurochem. 2004 Jun;89(5):1057-91. DOI: 10.1111/j.1471-4159.2004.02402.x. PMID:15147500.Olias G, Viollet C, Kusserow H, Epelbaum J, Meyerhof W. Regulation and function of somatostatin receptors. J Neurochem. 2004 Jun;89(5):1057-91. DOI: 10.1111/j.1471-4159.2004.02402.x. PMID:15147500.Chernov VI, Triss SV, Skuridin VS, Lishmanov YB. Thallium-199: a new radiopharmaceutical for myocardial perfusion imaging. Int J Card Imaging. 1996 Jun;12(2):119-26.Chernov VI, Triss SV, Skuridin VS, Lishmanov YB. Thallium-199: a new radiopharmaceutical for myocardial perfusion imaging. Int J Card Imaging. 1996 Jun;12(2):119-26.Kamaleshwaran KK, Rajkumar N, Mohanan V, Kalarikal R, Shinto AS. 99mTc-ubiquicidin scintigraphy in diagnosis of knee prosthesis infection and comparison with 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Indian J Nucl Med. 2015;30(3):259-62. DOI: 10.4103/0972-3919.158540.Kamaleshwaran KK, Rajkumar N, Mohanan V, Kalarikal R, Shinto AS. 99mTc-ubiquicidin scintigraphy in diagnosis of knee prosthesis infection and comparison with 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Indian J Nucl Med. 2015;30(3):259-62. DOI: 10.4103/0972-3919.158540.Weinstein EA, Ordonez AA, DeMarco VP. Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography. Sci Trans Med. 2014;6(259):259ra146. DOI: 10.1126/scitranslmed.3009815.Weinstein EA, Ordonez AA, DeMarco VP. Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography. Sci Trans Med. 2014;6(259):259ra146. DOI: 10.1126/scitranslmed.3009815.Al-Shiekh W, Sfakinaskis GN, Mnaymen W. Subacute and chronic bone infections: diagnosis with 111In, 67Ga and 99m Tc MDP and radiography. Radiology. 1985;155:501-6.Al-Shiekh W, Sfakinaskis GN, Mnaymen W. Subacute and chronic bone infections: diagnosis with 111In, 67Ga and 99m Tc MDP and radiography. Radiology. 1985;155:501-6.Palestro C, Clark A, Grady E, Heiba S, Israel O, Klitzke A, et al. Appropriate Use Criteria for the Use of Nuclear Medicine in Musculoskeletal Infection Imaging. J Nucl Med. 2021;62(12):1815-31. DOI: 10.2967/jnumed.121.262579.Palestro C, Clark A, Grady E, Heiba S, Israel O, Klitzke A, et al. Appropriate Use Criteria for the Use of Nuclear Medicine in Musculoskeletal Infection Imaging. J Nucl Med. 2021;62(12):1815-31. DOI: 10.2967/jnumed.121.262579.Huang JY, Yen RF, Huang CK, Liu CJ, Cheng MF, Chien KL, Wu YW. Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study. PLoS One. 2021;16(10): e0258983. DOI: 10.1371/journal.pone.0258983.Huang JY, Yen RF, Huang CK, Liu CJ, Cheng MF, Chien KL, Wu YW. Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study. PLoS One. 2021;16(10): e0258983. DOI: 10.1371/journal.pone.0258983.Hamada M, Shigematsu Y, Nakata S, Kuwahara T, Ikeda S, Ohshima K, Ogimoto A. Predicting the clinical course in hypertrophic cardiomyopathy using thallium-201 myocardial scintigraphy. ESC Heart Fail. 2021;8(2):1378-87. DOI: 10.1002/ehf2.13218.Hamada M, Shigematsu Y, Nakata S, Kuwahara T, Ikeda S, Ohshima K, Ogimoto A. Predicting the clinical course in hypertrophic cardiomyopathy using thallium-201 myocardial scintigraphy. ESC Heart Fail. 2021;8(2):1378-87. DOI: 10.1002/ehf2.13218.Kim C, Lee SJ, Kim JY, Hwang KT, Choi YY. Comparative Analysis of 99mTc-MDP Three-Phase Bone Scan with SPECT/CT and 99mTc-HMPAO-Labeled WBC SPECT/CT in the Differential Diagnosis of Clinically Suspicious Post-traumatic Osteomyelitis. Nucl Med Mol Imaging. 2017;51(1):40-8. DOI: 10.1007/s13139-016-0441-x.Kim C, Lee SJ, Kim JY, Hwang KT, Choi YY. Comparative Analysis of 99mTc-MDP Three-Phase Bone Scan with SPECT/CT and 99mTc-HMPAO-Labeled WBC SPECT/CT in the Differential Diagnosis of Clinically Suspicious Post-traumatic Osteomyelitis. Nucl Med Mol Imaging. 2017;51(1):40-8. DOI: 10.1007/s13139-016-0441-x.Davina K. Hughes Nuclear Medicine and Infection Detection: The Relative Effectiveness of Imaging with 111In-Oxine-, 99mTc-HMPAO-, and 99mTc-Stannous Fluoride Colloid-Labeled Leukocytes and with 67Ga-Citrate. J. Nucl. Med. Technol. 2003;31:196-201.Davina K. Hughes Nuclear Medicine and Infection Detection: The Relative Effectiveness of Imaging with 111In-Oxine-, 99mTc-HMPAO-, and 99mTc-Stannous Fluoride Colloid-Labeled Leukocytes and with 67Ga-Citrate. J. Nucl. Med. Technol. 2003;31:196-201.Holcman K, Rubiś P, Stępień A, Graczyk K, Podolec P, Kostkiewicz M. The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac Device-Related Infective Endocarditis-A Systematic Review. J Pers Med. 2021;11(10):1016. DOI: 10.3390/jpm11101016.Holcman K, Rubiś P, Stępień A, Graczyk K, Podolec P, Kostkiewicz M. The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac Device-Related Infective Endocarditis-A Systematic Review. J Pers Med. 2021;11(10):1016. DOI: 10.3390/jpm11101016.Roca M, de Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with 111In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37(4):835-41. DOI: 10.1007/s00259-010-1393-5.Roca M, de Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with 111In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37(4):835-41. DOI: 10.1007/s00259-010-1393-5.Лишманов ЮБ, Чернов ВИ, Кривоногов НГ, Ефимова ИЮ, Веснина ЖВ, Завадовский КВ. Радионуклидные методы исследования в диагностике сердечно-сосудистых заболеваний. Сибирский медицинский журнал. 2010;25(4-1):8-13.Lishmanov YuB, Chernov VI, Krivonogov NG, Efimova IYu, Vesnina ZhV, Zavadovsky KV. Radionuclide research methods in the diagnosis of cardiovascular diseases. Siberian Medical Journal. 2010;25(4-1):8-13. (In Russian).Man F, Khan AA, Carrascal-Miniño A, Blower PJ, TM de Rosales R. A kit formulation for the preparation of [ 89 Zr]Zr(oxinate)4 for PET cell tracking: White blood cell labelling and comparison with [ 111In]In(oxinate)3 . Nucl Med Biol. 2020;90-91:31-40. DOI: 10.1016/j.nucmedbio.2020.09.002.Man F, Khan AA, Carrascal-Miniño A, Blower PJ, TM de Rosales R. A kit formulation for the preparation of [ 89 Zr]Zr(oxinate)4 for PET cell tracking: White blood cell labelling and comparison with [ 111In]In(oxinate)3 . Nucl Med Biol. 2020;90-91:31-40. DOI: 10.1016/j.nucmedbio.2020.09.002.Mairal L, de Lima PA, Martin-Comin J, Baliellas C, Xiol X, Roca M, Ricart Y, Ramos M. Simultaneous administration of 111In-human immunoglobulin and 99mTc-HMPAO labelled leucocytes in inflammatory bowel disease. Eur J Nucl Med. 1995;22(7):664-70. DOI: 10.1007/BF01254568.Mairal L, de Lima PA, Martin-Comin J, Baliellas C, Xiol X, Roca M, Ricart Y, Ramos M. Simultaneous administration of 111In-human immunoglobulin and 99mTc-HMPAO labelled leucocytes in inflammatory bowel disease. Eur J Nucl Med. 1995;22(7):664-70. DOI: 10.1007/BF01254568.Lauri C, Glaudemans AWJM, Campagna G. Comparison of White Blood Cell Scintigraphy, FDG PET/CT and MRI in Suspected Diabetic Foot Infection: Results of a Large Retrospective Multicenter Study. J Clin Med. 2020;9(6):1645. DOI: 10.3390/jcm9061645Lauri C, Glaudemans AWJM, Campagna G. Comparison of White Blood Cell Scintigraphy, FDG PET/CT and MRI in Suspected Diabetic Foot Infection: Results of a Large Retrospective Multicenter Study. J Clin Med. 2020;9(6):1645. DOI: 10.3390/jcm9061645Tregay N, Begg M, Cahn A, Farahi N, Povey K, Madhavan S, et al. Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD. Thorax. 2019;74(7):659-66. DOI: 10.1136/thoraxjnl-2018-212509.Tregay N, Begg M, Cahn A, Farahi N, Povey K, Madhavan S, et al. Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD. Thorax. 2019;74(7):659-66. DOI: 10.1136/thoraxjnl-2018-212509.Hay RV, Skinner RS, Newman OC, Kunkel SL, Lyle LR, Shapiro B, Gross MD. Scintigraphy of acute inflammatory lesions in rats with radiolabelled recombinant human interleukin-8. Nucl Med Commun. 1997;18(4):367-78. DOI: 10.1097/00006231-199704000-00178.Hay RV, Skinner RS, Newman OC, Kunkel SL, Lyle LR, Shapiro B, Gross MD. Scintigraphy of acute inflammatory lesions in rats with radiolabelled recombinant human interleukin-8. Nucl Med Commun. 1997;18(4):367-78. DOI: 10.1097/00006231-199704000-00178.Van der Laken J, Boerman OC, Oyen WJG. Recombination human interleukin-I: potential agent to image infectious foci. Eur. J. Nucl. Med. 1994;21:790.Van der Laken J, Boerman OC, Oyen WJG. Recombination human interleukin-I: potential agent to image infectious foci. Eur. J. Nucl. Med. 1994;21:790.Britton KE, Wareham DW, Das SS. Imaging bacterial infection with ( 99m )Tc-ciprofloxacin (Infecton). J Clin Pathol. 2002;55(11):817-23. DOI: 10.1136/jcp.55.11.817Britton KE, Wareham DW, Das SS. Imaging bacterial infection with ( 99m )Tc-ciprofloxacin (Infecton). J Clin Pathol. 2002;55(11):817-23. DOI: 10.1136/jcp.55.11.817Sambri A, Spinnato P, Tedeschi S, Zamparini E, Fiore M, Zucchini R, et al. Bone and Joint Infections: The Role of Imaging in Tailoring Diagnosis to Improve Patients’ Care. J Pers Med. 2021;11(12):1317. DOI: 10.3390/jpm11121317.Sambri A, Spinnato P, Tedeschi S, Zamparini E, Fiore M, Zucchini R, et al. Bone and Joint Infections: The Role of Imaging in Tailoring Diagnosis to Improve Patients’ Care. J Pers Med. 2021;11(12):1317. DOI: 10.3390/jpm11121317.Ashcheulova DO, Efimova LV, Lushchyk AY, Yantsevich AV, Baikov AN, Pershina AG. Production of the recombinant antimicrobial peptide UBI18-35 in Escherichia coli. Protein Expr Purif. 2018;143:38-44. DOI: 10.1016/j.pep.2017.10.011.Ashcheulova DO, Efimova LV, Lushchyk AY, Yantsevich AV, Baikov AN, Pershina AG. Production of the recombinant antimicrobial peptide UBI18-35 in Escherichia coli. Protein Expr Purif. 2018;143:38-44. DOI: 10.1016/j.pep.2017.10.011.Kang SR, Min JJ. Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria. Nucl Med Mol Imaging. 2021;55(1):7-14. DOI: 10.1007/s13139-021-00689-4.Kang SR, Min JJ. Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria. Nucl Med Mol Imaging. 2021;55(1):7-14. DOI: 10.1007/s13139-021-00689-4.Bahtouee M, Saberifard J, Javadi H, Nabipour I, Malakizadeh H, Monavvarsadegh G, et al. 99m TcIgG-Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study. Iran J Radiol. 2015;12(4): e14619. DOI: 10.5812/iranjradiol.14619v2.Bahtouee M, Saberifard J, Javadi H, Nabipour I, Malakizadeh H, Monavvarsadegh G, et al. 99m TcIgG-Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study. Iran J Radiol. 2015;12(4): e14619. DOI: 10.5812/iranjradiol.14619v2.Salmanoglu E, Kim S, Thakur ML. Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail. Semin Nucl Med. 2018;48(2):86-99. DOI: 10.1053/j.semnuclmed.2017.10.003Salmanoglu E, Kim S, Thakur ML. Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail. Semin Nucl Med. 2018;48(2):86-99. DOI: 10.1053/j.semnuclmed.2017.10.003Milito C, Cinetto F, Megna V, Spadaro G, Quinti I, Liberatore M. The Usefulness of Scintigraphic Studies in the Assessment of Asymptomatic Bowel Disease in Patients with Primary Antibody Diseases. J Clin Med. 2020;9(4):949. DOI: 10.3390/jcm9040949.Milito C, Cinetto F, Megna V, Spadaro G, Quinti I, Liberatore M. The Usefulness of Scintigraphic Studies in the Assessment of Asymptomatic Bowel Disease in Patients with Primary Antibody Diseases. J Clin Med. 2020;9(4):949. DOI: 10.3390/jcm9040949.Shanthly N, Aruva MR, Zhang K, Mathew B, Thakur ML. 99mTc-fanolesomab: affinity, pharmacokinetics and preliminary evaluation. Q J Nucl Med Mol Imaging. 2006;50(2):104-12. PMID:16770300.Shanthly N, Aruva MR, Zhang K, Mathew B, Thakur ML. 99mTc-fanolesomab: affinity, pharmacokinetics and preliminary evaluation. Q J Nucl Med Mol Imaging. 2006;50(2):104-12. PMID:16770300.Love C, Tronco GG, Palestro CJ. Imaging of infection and inflammation with 99mTc-Fanolesomab. Q J Nucl Med Mol Imaging. 2006;50(2):113-20.Love C, Tronco GG, Palestro CJ. Imaging of infection and inflammation with 99mTc-Fanolesomab. Q J Nucl Med Mol Imaging. 2006;50(2):113-20.Анохин ЮН. Использование нанотехнологий и наноматериалов для визуализации и терапии злокачественных опухолей. Фундаментальные проблемы науки. 2010;(3):221-4.Anokhin YuN. Use of nanotechnologies and nanomaterials for visualization and therapy of malignant tumors. Fundamental Problems of Science. 2010;(3):221-4. (In Russian).Guberina N, Gäckler A, Grueneisen J, Wetter A, Witzke O, Herrmann K, et al. Assessment of Suspected Malignancy or Infection in Immunocompromised Patients After Solid Organ Transplantation by [ 18F]FDG PET/CT and [ 18F]FDG PET/MRI. Nucl Med Mol Imaging. 2020;54(4):183-91. DOI: 10.1007/s13139-020-00648-5.Guberina N, Gäckler A, Grueneisen J, Wetter A, Witzke O, Herrmann K, et al. Assessment of Suspected Malignancy or Infection in Immunocompromised Patients After Solid Organ Transplantation by [ 18F]FDG PET/CT and [ 18F]FDG PET/MRI. Nucl Med Mol Imaging. 2020;54(4):183-91. DOI: 10.1007/s13139-020-00648-5.Ahmad Sarji S. Physiological uptake in FDG PET simulating disease. Biomed Imaging Interv J. 2006;2(4):e59.Ahmad Sarji S. Physiological uptake in FDG PET simulating disease. Biomed Imaging Interv J. 2006;2(4):e59.Ergül N, Halac M, Cermik TF. The Diagnostic Role of FDG PET/CT in Patients with Fever of Unknown Origin. Mol Imaging Radionucl Ther. 2011;20(1):19-25. DOI: 10.4274/MIRT.20.04Ergül N, Halac M, Cermik TF. The Diagnostic Role of FDG PET/CT in Patients with Fever of Unknown Origin. Mol Imaging Radionucl Ther. 2011;20(1):19-25. DOI: 10.4274/MIRT.20.04Giesel FL, Hadaschik B, Cardinale J, Radtke J, Vinsensia M, Lehnert W, et al. F-18 labelled PSMA1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur J Nucl Med Mol Imaging. 2017;44(4):678-88. DOI: 10.1007/s00259-016-3573-4.Giesel FL, Hadaschik B, Cardinale J, Radtke J, Vinsensia M, Lehnert W, et al. F-18 labelled PSMA1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur J Nucl Med Mol Imaging. 2017;44(4):678-88. DOI: 10.1007/s00259-016-3573-4.Awenat S, Piccardo A, Carvoeiras P, Signore G, Giovanella L, Prior JO, Treglia G. Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review. Diagnostics (Basel). 2021;11(3):552. DOI: 10.3390/diagnostics11030552.Awenat S, Piccardo A, Carvoeiras P, Signore G, Giovanella L, Prior JO, Treglia G. Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review. Diagnostics (Basel). 2021;11(3):552. DOI: 10.3390/diagnostics11030552.Ларенков АА, Кодина ГЕ, Брускин АБ. Радионуклиды галлия в ядерной медицине: радиофармацевтические препараты на основе изотопа 68Ga. Медицинская радиология и радиационная безопасность. 2011;56(5):56-73.Larenkov AA, Kodina GE, Bruskin AB. Gallium radionuclides in nuclear medicine: radiopharmaceuticals based on the 68Ga isotope. Medical Radiology and Radiation Safety. 2011;56(5):56-73. (In Russian).Wild D, Bomanji JB, Benkert P, Maecke H, Ell PJ, Reubi JC, Caplin ME. Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors. J Nucl Med. 2013;54(3):364-72.Wild D, Bomanji JB, Benkert P, Maecke H, Ell PJ, Reubi JC, Caplin ME. Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors. J Nucl Med. 2013;54(3):364-72.Bozkurt MF, Virgolini I, Balogova S, Beheshti M, Rubello D, Decristoforo C, et al. Guideline for PET/ CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA. Eur J Nucl Med Mol Imaging. 2017;44(9):1588-601. DOI: 10.1007/s00259-017-3728-y.Bozkurt MF, Virgolini I, Balogova S, Beheshti M, Rubello D, Decristoforo C, et al. Guideline for PET/ CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA. Eur J Nucl Med Mol Imaging. 2017;44(9):1588-601. DOI: 10.1007/s00259-017-3728-y.Lindner T, Loktev A, Giesel F, Kratochwil C, Altmann A, Haberkorn U. Targeting of activated fibroblasts for imaging and therapy. EJNMMI Radiopharm Chem. 2019;4(1):16. DOI: 10.1186/s41181-019-0069-0.Lindner T, Loktev A, Giesel F, Kratochwil C, Altmann A, Haberkorn U. Targeting of activated fibroblasts for imaging and therapy. EJNMMI Radiopharm Chem. 2019;4(1):16. DOI: 10.1186/s41181-019-0069-0.Windisch P, Zwahlen DR, Koerber SA, Giesel FL, Debus J, Haberkorn U, Adeberg S. Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review. Cancers (Basel). 2020 Sep 15;12(9):2629.Windisch P, Zwahlen DR, Koerber SA, Giesel FL, Debus J, Haberkorn U, Adeberg S. Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review. Cancers (Basel). 2020 Sep 15;12(9):2629.

The authors declare that there are no conflicts of interest present.