ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2020-3-4-18-25ojrdrt-141Research ArticleЛУЧЕВАЯ ТЕРАПИЯRADIOTHERAPYОпределение объемов облучения при дистанционной лучевой терапии глиом высокой степени злокачественностиTarget Volume Delineation for Radiation Therapy of High-Grade Gliomashttps://orcid.org/0000-0002-9914-8990ШейкоА. В.SheikoA. V.

Шейко Андрей Владимирович — заведующий радио терапевтическим отделением № 2 ГБУЗ ВО «Област ной клинический онкологический диспансер»

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andreysheyko87@gmail.comГБУЗ ВО «Областной клинический онкологический диспансер»РоссияVladimir Regional Clinical Oncology CenterRussian Federation202031122020341825Copyright © Шейко А.В., 20202020Шейко А.В.Sheiko A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/141

Глиомы высокой степени злокачественности характеризуются быстрым ростом, неблагоприятным прогнозом и частыми неудовлетворительными результатами лечения. Лучевая терапия остается одним из основных методов лечения данного заболевания. Однако до сих пор вопрос выбора оптимального макроскопического (Gross Tumor Volume — GTV) и клинического (Clinical Target Volume — CTV) объемов при планировании лучевого лечения остается спорным. Существует несколько подходов к определению радиотерапевтических объемов при лучевом лечении глиом высокой степени злокачественности в зависимости от отношения к перитуморальному отеку. Корреляции между частотой центральных рецидивов и методиками оконтуривания глиом высокой степени злокачественности обнаружено не было. GTV должен определяться как зона повышенного сигнала на постконтрастном взвешенном по Т1 МРТ-изображении, т.е. GTV должен включать послеоперационную полость и остаточную опухоль. Перитуморальный отек — ненадежный ориентир при оконтуривании целевых объемов.

High-grade gliomas are characterized by rapid growth, poor prognosis and frequent unsatisfactory treatment results. Radiation therapy remains one of the main methods of treatment of this disease. However, the question of choosing the optimal macroscopic (Gross Tumor Volume — GTV) and clinical (Clinical Target Volume — CTV) volumes in the planning of radiation treatment remains controversial. There are several approaches to the target volume delineation for radiotherapy of high-grade gliomas, depending on the peritumoral edema. There is no correlation between the frequency of recurrences and methods of delineation of gliomas. GTV should be defined as the area of enhancement on the post-contrast T1-weighted MRI, i.e. postoperative cavity and residual tumor. Peritumoral edema is an unreliable orienting point when contouring target volumes.

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The authors declare that there are no conflicts of interest present.