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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ojrdrt</journal-id><journal-title-group><journal-title xml:lang="ru">Онкологический журнал: лучевая диагностика, лучевая терапия</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of oncology: diagnostic radiology and radiotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2587-7593</issn><issn pub-type="epub">2713-167X</issn><publisher><publisher-name>НЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37174/2587-7593-2019-2-1-5-20</article-id><article-id custom-type="elpub" pub-id-type="custom">ojrdrt-14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛУЧЕВАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RADIOTHERAPY</subject></subj-group></article-categories><title-group><article-title>Протонная лучевая терапия: современное состояние и перспективы. Часть II. Радиобиологические и клинические аспекты</article-title><trans-title-group xml:lang="en"><trans-title>Proton Radiotherapy: Current Status and Future Prospects. Part 2. Radiobiological and clinical aspects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климанов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimanov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">vaklimanov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галяутдинова</surname><given-names>Ж. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Galjautdinova</surname><given-names>J. J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Забелин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zabelin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России; Национальный исследовательский ядерный университет «МИФИ»; Московский государственный университет им. М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Burnazyan Federal Medical Biophysical Center; National Research Nuclear University MEPhI; M.V. Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.I. Burnazyan Federal Medical Biophysical Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2019</year></pub-date><volume>2</volume><issue>1</issue><fpage>5</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Климанов В.А., Галяутдинова Ж.Ж., Забелин М.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Климанов В.А., Галяутдинова Ж.Ж., Забелин М.В.</copyright-holder><copyright-holder xml:lang="en">Klimanov V.A., Galjautdinova J.J., Zabelin M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.oncoradjournal.ru/jour/article/view/14">https://www.oncoradjournal.ru/jour/article/view/14</self-uri><abstract><p>Приведен аналитический обзор современного состояния протонной терапии в мире и в России, в частности, в области относительной биологической эффективности протонного облучения, клинических показаний к его применению, стоимости протонной терапии, перспектив ее дальнейшего развития и др. Часть I статьи опубликована в №4 журнала за 2018 г.</p></abstract><trans-abstract xml:lang="en"><p>An analytical review of the current state of proton therapy in the world and in Russia is given, in particular, in the area of the relative biological effectiveness of proton irradiation, clinical indications for its use, the cost of proton therapy, the prospects for its further development, etc.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лучевая терапия</kwd><kwd>протоны</kwd><kwd>радиобиология</kwd><kwd>клиническое применение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radiation therapy</kwd><kwd>protons</kwd><kwd>relative biological effectiveness</kwd><kwd>clinical studies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson R.R. Radiological use of fast proton // Radiology. Vol. 47. 1946. P. 487-491.</mixed-citation><mixed-citation xml:lang="en">Wilson R.R. 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