ojrdrtОнкологический журнал: лучевая диагностика, лучевая терапияJournal of oncology: diagnostic radiology and radiotherapy2587-75932713-167XНЕКОММЕРЧЕСКОЕ ПАРТНЕРСТВО «ОБЩЕСТВО ИНТЕРВЕНЦИОННЫХ ОНКОРАДИОЛОГОВ»10.37174/2587-7593-2018-1-3-10-14ojrdrt-11Research ArticleЯДЕРНАЯ МЕДИЦИНАNUCLEAR MEDICINEПроизводство радиофармацевтического лекарственного средства 18F-фтордезоксиглюкозаProduction of Radiopharmaceutical Medicinal Product 18F-FluorodeoxyglucoseНевзоровД. И.NevzorovD. I.СкрипачевИ. А.SkripachevI. A.i.skripachev@gmail.comДолгушинМ. Б.DolgushinM. B.ОджароваА. А.OdzharovaA. A.ЕреминН. В.EreminN. V.Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РФРоссияN.N. Blokhin National Medical Research Center of OncologyRussian Federation201830092018131014Copyright © Невзоров Д.И., Скрипачев И.А., Долгушин М.Б., Оджарова А.А., Еремин Н.В., 20182018Невзоров Д.И., Скрипачев И.А., Долгушин М.Б., Оджарова А.А., Еремин Н.В.Nevzorov D.I., Skripachev I.A., Dolgushin M.B., Odzharova A.A., Eremin N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.oncoradjournal.ru/jour/article/view/11

В работе рассмотрен современный коммерческий способ производства самого востребованного в онкологии радиофармацевтического диагностического лекарственного средства 18F-фтордезоксиглюкозы (2-фтор-18F-2-дезокси-D-глюкоза, 18F-ФДГ), представлены технологические стадии и операции синтеза, процедуры контроля качества, кратко описаны требования, предъявляемые к упаковке и маркировке данного радиофармацевтического препарата.

In the article considers modern commercial method of production is demanded used in oncology medical product radiopharmaceutical 18F-fluorodeoxyglucose (2-fluoro-18F-2-deoxy-D-glucose, 18F-FDG), are presented the process steps and operation of synthesis, quality control procedures, briefly described the requirements for packaging and labeling of radiopharmaceutical.

18F-фтордезоксиглюкозасинтезрадиофармацевтический препаратРФПпозитронная эмиссионная тоМография18F-fluorodeoxyglucosesynthesisradiopharmaceuticalpositron emission tomographyReferencesKam Leung. 2005. [18F]Fluoro-2-deoxy-2-D-glucose in Molecular Imaging and Contrast Agent Database (MICAD). National Center for Biotechnology Information, NLM, NIH, Bethesda, MD.Kam Leung. 2005. [18F]Fluoro-2-deoxy-2-D-glucose in Molecular Imaging and Contrast Agent Database (MICAD). National Center for Biotechnology Information, NLM, NIH, Bethesda, MD.Zanoni L., Al-Sugair A.S., Fanti S. Clinical applications of 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography-computed tomography (PET/CT) // Nucl. Med. Rev. 2012. Vol. 15. Suppl. P. C48–C51.Zanoni L., Al-Sugair A.S., Fanti S. Clinical applications of 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography-computed tomography (PET/CT) // Nucl. Med. Rev. 2012. Vol. 15. Suppl. P. C48–C51.Тулин П. Е., Долгушин М. Б., Патютко И. Ю. и соавт. ПЭТ/КТ с 18F-ФДГ и 18F-холином в диагностике смешанного гепатохолангиоцеллюлярного рака (клиническое наблюдение) // Диагн. и интервенц. радиол. 2015. Т. 9. № 1. C. 91–99.Тулин П. Е., Долгушин М. Б., Патютко И. Ю. и соавт. ПЭТ/КТ с 18F-ФДГ и 18F-холином в диагностике смешанного гепатохолангиоцеллюлярного рака (клиническое наблюдение) // Диагн. и интервенц. радиол. 2015. Т. 9. № 1. C. 91–99.Min-Fu Yang, Diwakar Jain, Zuo-Xiang He. 18F-FDG cardiac studies for identifying ischemic memory // Curr. Cardiovasc. Imaging Rep. 2012. Vol. 5. P. 383–389.Min-Fu Yang, Diwakar Jain, Zuo-Xiang He. 18F-FDG cardiac studies for identifying ischemic memory // Curr. Cardiovasc. Imaging Rep. 2012. Vol. 5. P. 383–389.Ghesani M., Depuey E.G., Rozanski A. Role of F-18 FDG positron emission tomography (PET) in the assessment of myocardial viability // Echocardiography. 2005. Vol. 22. № 2. P. 165–177.Ghesani M., Depuey E.G., Rozanski A. Role of F-18 FDG positron emission tomography (PET) in the assessment of myocardial viability // Echocardiography. 2005. Vol. 22. № 2. P. 165–177.Nose H., Otsuka H., Otomi Y. et al. Evaluation of normal physiologic left ventricular myocardial 18F-FDG uptake at fasting state // Europ. Congress of Radiol. 1-5 March, 2012. Vienna, Austria. URL: http://posterng.netkey.at/esr/viewing/index.php?module=viewing_poster&doi=10.1594/ecr2012/C-11922012.Nose H., Otsuka H., Otomi Y. et al. Evaluation of normal physiologic left ventricular myocardial 18F-FDG uptake at fasting state // Europ. Congress of Radiol. 1-5 March, 2012. Vienna, Austria. URL: http://posterng.netkey.at/esr/viewing/index.php?module=viewing_poster&doi=10.1594/ecr2012/C-11922012.Dong Soo Lee, Sang Kun Lee, Myung Chul Lee. Functional neuroimaging in epilepsy: FDG PET and Ictal SPECT // Korean Medю Sci. 2001. Vol. 16. P. 689–696.Dong Soo Lee, Sang Kun Lee, Myung Chul Lee. Functional neuroimaging in epilepsy: FDG PET and Ictal SPECT // Korean Medю Sci. 2001. Vol. 16. P. 689–696.Teune L.K., Bartels A.L., Leenders K.L. FDG-PET Imaging in neurodegenerative brain diseases // In: Functional Brain Mapping and the Endeavor to Understand the Working Brain. Ed. by F. Signorelli and D. Chirchiglia. 2013.Teune L.K., Bartels A.L., Leenders K.L. FDG-PET Imaging in neurodegenerative brain diseases // In: Functional Brain Mapping and the Endeavor to Understand the Working Brain. Ed. by F. Signorelli and D. Chirchiglia. 2013.Sanchez-Catasus C.A., Vallez Garcia D., Le Riverend Morales E., Galvizu S.R. Traumatic brain injury // In: Nuclear Medicine Neuroimaging. PET and SPECT in Neurology, 2014. P. 923–946.Sanchez-Catasus C.A., Vallez Garcia D., Le Riverend Morales E., Galvizu S.R. Traumatic brain injury // In: Nuclear Medicine Neuroimaging. PET and SPECT in Neurology, 2014. P. 923–946.Masangkay N., Basu S., Moghbel M. et al. Brain 18F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings // Nucl. Med. Commun. 2014. Vol. 35. № 10. P. 1038–1046.Masangkay N., Basu S., Moghbel M. et al. Brain 18F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings // Nucl. Med. Commun. 2014. Vol. 35. № 10. P. 1038–1046.Jones S.C., Alavi A., Christman D. et al. The radiation dosimetry of 2-[F-18]fluoro-2-deoxy-D-glucose in man // J. Nucl. Med. 1982. Vol. 23. P. 613–617.Jones S.C., Alavi A., Christman D. et al. The radiation dosimetry of 2-[F-18]fluoro-2-deoxy-D-glucose in man // J. Nucl. Med. 1982. Vol. 23. P. 613–617.Ido T., Wan C.N., Fowler J.S. Fluorination with F2: convenient synthesis of 2-deoxy-2-fluoro-d-glucose // J. Org. Chem. 1977. Vol. 42. P. 2341–2342.Ido T., Wan C.N., Fowler J.S. Fluorination with F2: convenient synthesis of 2-deoxy-2-fluoro-d-glucose // J. Org. Chem. 1977. Vol. 42. P. 2341–2342.Hamacher K., Coenen H.H., Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution // J. Nucl. Med. 1986. Vol. 27. P. 235–238.Hamacher K., Coenen H.H., Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution // J. Nucl. Med. 1986. Vol. 27. P. 235–238.Toorongian S.A., Mulholland G.K., Jewett D.M. et al. Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin // Int. J. Rad. Appl. Instrum. B. 1990. Vol. 17. № 3. P. 273–279.Toorongian S.A., Mulholland G.K., Jewett D.M. et al. Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin // Int. J. Rad. Appl. Instrum. B. 1990. Vol. 17. № 3. P. 273–279.СанПиН 2.6.1.3288-15. Гигиенические требования по обеспечению радиационной безопасности при подготовке и проведении позитронной эмиссионной томографии.СанПиН 2.6.1.3288-15. Гигиенические требования по обеспечению радиационной безопасности при подготовке и проведении позитронной эмиссионной томографии.Gomzina N.A., Vasil’ev D.A., Krasikova R.N. Optimization of automated synthesis of 2-[18F]Fluoro-2-deoxy-D-glucose involving base hydrolysis // Radiochemistry. 2002. Vol. 44. № 4. P. 403–409.Gomzina N.A., Vasil’ev D.A., Krasikova R.N. Optimization of automated synthesis of 2-[18F]Fluoro-2-deoxy-D-glucose involving base hydrolysis // Radiochemistry. 2002. Vol. 44. № 4. P. 403–409.Gopal B. Saha. Basics of PET Imaging: Physics, Chemistry and Regulations. 3th ed. – New York: Springer International Publishing. 2016. 165 pp.Gopal B. Saha. Basics of PET Imaging: Physics, Chemistry and Regulations. 3th ed. – New York: Springer International Publishing. 2016. 165 pp.

The authors declare that there are no conflicts of interest present.